Recent advances in carbon monoxide-releasing nanomaterials DOI Creative Commons
Xiaomei Ning, Xinyuan Zhu, Youfu Wang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 30 - 50

Published: March 14, 2024

As an endogenous signaling molecule, carbon monoxide (CO) has emerged as increasingly promising option regarding gas therapy due to its positive pharmacological effects in various diseases. Owing the gaseous nature and potential toxicity, it is particularly important modulate CO release dosages targeted locations elucidate biological mechanisms of facilitate clinical applications. Based on these, diverse CO-releasing molecules (CORMs) have been developed for controlled systems. However, practical applications these CORMs are limited by several disadvantages including low stability, poor solubility, weak releasing controllability, random diffusion, toxicity. In light rapid developments advantages nanomedicine, abundant nanomaterials ways therapeutic purposes across Due their nanoscale sizes, diversified compositions modified surfaces, vast (CORNMs) constructed exhibited specific under stimuli with better pharmacokinetics pharmacodynamics. this review, we present recent progress CORNMs according compositions. Following a concise introduction therapy, CORNMs, representative research from organic nanostructures, hybrid nanomaterials, inorganic nanocomposites elaborated. The basic properties such active components, mechanisms, detection methods, applications, discussed detail listed table. Finally, explore discuss prospects challenges associated utilizing release.

Language: Английский

Recent advances in nanoparticle-based photothermal therapy for breast cancer DOI
Sania Ghobadi Alamdari, Mohammad Amini, Nazila Jalilzadeh

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 269 - 303

Published: July 9, 2022

Language: Английский

Citations

177
Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy DOI
Xiaoliang Qi,

Yajing Xiang,

Erya Cai

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215426 - 215426

Published: Sept. 6, 2023

Language: Английский

Citations

133
Biodegradable Metal–Organic‐Framework‐Gated Organosilica for Tumor‐Microenvironment‐Unlocked Glutathione‐Depletion‐Enhanced Synergistic Therapy DOI
Yuanyuan Ma, Zheng Su, Liming Zhou

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(12)

Published: Dec. 13, 2021

The clinical employment of cisplatin (cis-diamminedichloroplatinum(II) (CDDP)) is largely constrained due to the non-specific delivery and resultant serious systemic toxicity. Small-sized biocompatible biodegradable hollow mesoporous organosilica (HMOS) nanoparticles show superior advantages for targeted CDDP but suffer from premature leakage. Herein, smart use a bimetallic Zn2+ /Cu2+ co-doped metal-organic framework (MOF) made block pores HMOS preventing potential leakage remarkably increasing loading capacity HMOS. Once reaching acidic tumor microenvironment (TME), outer MOF can decompose quickly release chemotherapy against cancer. Besides, concomitant dopant Cu2+ deplete intracellular glutathione (GSH) increased toxicity as well catalyzing decomposition intratumoral H2 O2 into highly toxic •OH chemodynamic therapy (CDT). Moreover, substantially reduced GSH also protect yielded scavenging thus greatly improve •OH-based CDT effect. In addition providing hybrid HMOS@MOF nanocarrier, this study expected establish new form TME-unlocked nanoformula efficient tumor-specific GSH-depletion-enhanced synergistic chemotherapy/chemodynamic therapy.

Language: Английский

Citations

105
Pulmonary Delivery of Theranostic Nanoclusters for Lung Cancer Ferroptosis with Enhanced Chemodynamic/Radiation Synergistic Therapy DOI
Yingbo Li, Jie Yang,

Guangying Gu

et al.

Nano Letters, Journal Year: 2022, Volume and Issue: 22(3), P. 963 - 972

Published: Jan. 24, 2022

Inefficient tumor accumulation and penetration remain as the main challenges to therapy efficacy of lung cancer. Local delivery smart nanoclusters can increase drug provide superior antitumor effects than systemic routes. Here, we report self-assembled pH-sensitive superparamagnetic iron oxide (SPIONCs) that enhance in situ ferroptosis apoptosis with radiotherapy chemodynamic therapy. After pulmonary orthotopic cancer, SPIONCs disintegrate into smaller nanoparticles release more ions an acidic microenvironment. Under single-dose X-ray irradiation, endogenous superoxide dismutase converts radicals produced by mitochondria hydrogen peroxide, which turn generates hydroxyl Fenton reaction from accumulated inside tumor. Finally, irradiation lipid peroxidation induce cell ferroptosis. Thus, rationally designed delivered a promising strategy for noninvasive imaging cancer synergistic

Language: Английский

Citations

70
Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy DOI
Jianfeng Guo, Yifang Zou,

Leaf Huang

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 5, 2023

Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is confirmed to activate the host immune system prevent, control, and eliminate tumors. Recently, a range chemotherapeutic drugs have been repurposed ICD inducers applied for tumor immunotherapy. However, several hurdles widespread application remain, namely poor water solubility, short blood circulation, non-specific tissue distribution, severe toxicity. Recent advances in nanotechnology pharmaceutical formulation foster development nano drug delivery systems tackle aforementioned expedite safe, effective, specific delivery. This review will describe barriers chemical highlight recent nanoformulations these

Language: Английский

Citations

55
Regulatory insights into nanomedicine and gene vaccine innovation: Safety assessment, challenges, and regulatory perspectives DOI Creative Commons
Eliana B. Souto, Cristina Blanco-Llamero, Karolline Krambeck

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 180, P. 1 - 17

Published: April 10, 2024

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques accurately gauge effectiveness. Regarding frameworks must be tailored address distinct challenges posed by genetic interventions, necessitating special considerations in efficacy evaluations, particularly concerning vector design, target specificity, long-term patient monitoring. Ethical such as autonomy, informed consent, privacy also demand careful attention, alongside intricate matter intellectual property rights, which balanced against imperative widespread access these life-saving treatments. Collaborative efforts among bodies, researchers, patent offices, private sector essential tackle effectively, international cooperation being especially crucial given global scope vaccine development. Striking right balance between safeguarding properties promoting public health vital fostering innovation equitable ground-breaking technologies, underscoring significance addressing hurdles fully harness benefits vaccines enhancing healthcare outcomes a scale. STATEMENT OF SIGNIFICANCE: Several biomaterials proposed development nanovaccines, from polymeric micelles, PLGA-/PEI-/PLL-nanoparticles, solid lipid nananoparticles, cationic lipoplexes, liposomes, hybrid materials, dendrimers, carbon nanotubes, hydrogels, quantum dots. Lipid nanoparticles (LNPs) have gained tremendous attention since US Food Drug Administration (FDA) approval Pfizer Moderna's COVID-19 raising awareness vaccines. review provides insights into current strategies issues, clinical trials. By navigating landscapes we can unlock full using range promising towards improving worldwide.

Language: Английский

Citations

36
Emerging role of exosomes in cancer therapy: progress and challenges DOI Creative Commons
Jiale Li,

Jiachong Wang,

Zigui Chen

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Language: Английский

Citations

19
A systematic review of nanocarriers used in medicine and beyond — definition and categorization framework DOI Creative Commons

Sabine Greßler,

Christina Hipfinger,

Florian Part

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 7, 2025

Nanocarriers are transport and encapsulation systems that primarily serve to protect improve the dispersibility of predominantly hydrophobic active ingredients but also enable their targeted delivery controlled release at site action. mainly made either organic or inorganic materials, various combinations materials in complex structures under development. Most nanocarriers represent entities rationally designed meet functional requirements a specific application. They can therefore be understood as Advanced Materials. Nanocarrier already being used medicine, cosmetics, agriculture, food, household products. variety products, ideally safe sustainable, may need registered before they placed on market. Inspired by medical research, increasingly for precision farming (nano-agrochemicals) such air fresheners lithium-ion batteries, could thus released into environment large quantities. To identification critical subsequent investigations, comprehensive literature review broad heterogeneous research field is provided, well an approach categorization based origin chemical composition constituent materials. A definition size (1–1000 nm) function proposed risk assessment.

Language: Английский

Citations

3
Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles DOI Open Access
Ruslan R. Kashapov, A. R. Ibragimova, Rais Pavlov

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 7055 - 7055

Published: June 30, 2021

Encapsulation of cargoes in nanocontainers is widely used different fields to solve the problems their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, functional activity improvement. This approach special importance biomedicine, since this makes it possible reduce limitations drug delivery related toxicity side effects therapeutics, low bioavailability biocompatibility. review highlights current progress use lipid systems deliver active substances human body. Various compositions modified with amphiphilic open-chain macrocyclic compounds, peptide molecules alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting organic inorganic parts. Such nanohybrid platforms include cerasomes, which considered as nanocarriers allowing inherent nanoparticles. Compositions based on mesoporous silica beginning acquire no less relevance due unique features, such advanced porous properties, well-proven efficiency versatility for highly efficient nanomaterials. The types nanoparticles, efficacy biomedical applications inorganic-polymer subject discussion review, challenges emphasized.

Language: Английский

Citations

65
New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials DOI Creative Commons

Hongtao Shi,

Zihang Huang,

Tianzhao Xu

et al.

EBioMedicine, Journal Year: 2022, Volume and Issue: 78, P. 103968 - 103968

Published: March 31, 2022

Myocardial infarction is lethal to patients because of insufficient blood perfusion vital organs. Several attempts have been made improve its prognosis, among which nanomaterial research offers an opportunity address this problem at the molecular level and has potential disease prevention, diagnosis, treatment significantly. Up now, nanomaterial-based technology played a crucial role in broad novel diagnostic therapeutic strategies for cardiac repair. This review summarizes various applications myocardial from multiple aspects, including high precision detection, pro-angiogenesis, regulating immune homeostasis, miRNA stem cell delivery vehicles. We also propose promising hotspots that not reported much yet, such as conjugating pro-angiogenetic elements with nanoparticles construct drug carriers, developing nanodrugs targeting other cells except macrophages infarcted myocardium or remote region. Though most those are preclinical lack clinical trials, there tremendous their further future.

Language: Английский

Citations

62