New strategies for lung cancer diagnosis and treatment: applications and advances in nanotechnology DOI Creative Commons
Jiaqi Feng,

Pengpeng Zhang,

Dingli Wang

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 13, 2024

Lung cancer leads in causing cancer-related mortality worldwide, continually posing a significant threat to human health. Current imaging diagnostic techniques, while offering non-invasive detection, suffer from issues such as insufficient sensitivity and the risks associated with radiation exposure. Pathological diagnosis, gold standard for confirmation, also faces challenges like invasiveness high costs. In treatment, surgery, radiotherapy, chemotherapy are main modalities, each encountering related precision, environmental adaptability, side effects. Nanotechnology's advancement provides new solutions diagnosis treatment of lung cancer, promising enhance accuracy reduce effects during treatment. This article introduces types nanomaterials used field comprehensive overview current research on application nanotechnology early screening, monitoring summarizing ongoing clinical findings.

Language: Английский

Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio-enzymatic Therapy DOI
Xianyu Zhu, Jiabin Wu, Ruixue Liu

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(11), P. 18849 - 18862

Published: Oct. 24, 2022

Single-atom nanozymes (SAzymes), with individually isolated metal atom as active sites, have shown tremendous potential enzyme-based drugs for enzymatic therapy. However, using SAzymes in tumor theranostics remains challenging because of deficient activity and insufficient endogenous H2O2. We develop an external-field-enhanced catalysis by atom-level engineered FeN4-centered nanozyme (FeN4-SAzyme) radio-enzymatic This FeN4-SAzyme exhibits peroxidase-like capable catalyzing H2O2 into hydroxyl radicals converting single-site FeII species to FeIII subsequent glutathione oxidase-like activity. Density functional theory calculations are used rationalize the origin self-cascade Importantly, X-rays can improve overall cascade reaction process via promoting conversion frequency FeII/FeIII. As a producer, natural glucose oxidase is further decorated onto surface yield final construct GOD@FeN4-SAzyme. The resulting GOD@FeN4-SAzyme not only supplies situ continuously produce highly toxic but also induces localized deposition radiation dose, subsequently inducing intensive apoptosis ferroptosis vitro. Such synergistic effect radiotherapy therapy allows improved growth inhibition minimal side effects vivo. Collectively, this work demonstrates introduction external fields enhance enzyme-like performance without changing their properties highlights robust therapeutic self-supplying amplifying reactions address limitations treatment.

Language: Английский

Citations

89
Recent advances in multi-configurable nanomaterials for improved chemodynamic therapy DOI

Junya Lu,

Yuanqi Yang,

Qingqing Xu

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 474, P. 214861 - 214861

Published: Oct. 1, 2022

Language: Английский

Citations

85
Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions DOI Creative Commons
Haiyan Gao,

Zhiping Cao,

Huanhuan Liu

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

Citations

65
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade DOI Creative Commons

Ying Xue,

Fujia Lu,

Zhenzhen Chang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 8, 2023

Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy immunotherapy unknown. Here we show the length of time deprivation affects tumoral ferroptosis differently. Prolonged prevents glutathione (GSH) depletion from exceeding death threshold by blocking cation transport regulator homolog 1 (CHAC1) protein synthesis. Whereas, short-term starvation accelerates stimulating CHAC1 transcription. In vivo, dietary with intermittent but not sustained augments ferroptosis. Intermittent also sensitizes tumor cells against CD8+ T cell-mediated cytotoxicity synergize checkpoint blockade upregulation. Clinically, correlates clinical benefits improved survival in cancer patients treated blockades. Lastly, triple combination deprivation, system xc- inhibitor PD-1 shows superior antitumor efficacy. Thus, is a promising regimen target augment immunotherapy.

Language: Английский

Citations

58
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

4
Targeting ferroptosis as a vulnerability in pulmonary diseases DOI Creative Commons
Li Yang, Limian Cao, Xiaoju Zhang

et al.

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(7)

Published: July 26, 2022

Abstract Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing (PUFA-PLs) are highly susceptible to lipid peroxidation under stress. Numerous pulmonary diseases occurrences and degenerative pathologies driven ferroptosis. This review discusses the role of ferroptosis in pathogenesis including asthma, lung injury, cancer, fibrotic diseases, infection. Additionally, it proposed that targeting a potential treatment for particularly drug-resistant cancer or antibiotic-resistant infection, reduces treatment-related adverse events.

Language: Английский

Citations

60
Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer DOI Creative Commons
Chunmei Zhang, Ning Liu

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 25, 2022

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and a heterogeneous disease with complex molecular genetic changes. Because relatively high recurrence rate OC, it crucial to understand associated mechanisms drug resistance discover potential target for rational targeted therapy. Cell genetically determined process. Active orderly cell prevalent during development living organisms plays critical role regulating life homeostasis. Ferroptosis, novel type discovered recent years, distinct from apoptosis necrosis mainly caused by imbalance between production degradation intracellular lipid reactive oxygen species triggered increased iron content. Necroptosis regulated non-cysteine protease–dependent programmed necrosis, morphologically exhibiting same features as occurring via unique mechanism different apoptotic signaling pathway. Pyroptosis form characterized formation membrane pores subsequent lysis well release pro-inflammatory contents mediated abscisin family. Studies have shown ferroptosis, necroptosis, pyroptosis are involved progression variety diseases, including tumors. In this review, we summarized advances occurrence, development, therapeutic OC.

Language: Английский

Citations

58
Recent advances in augmenting Fenton chemistry of nanoplatforms for enhanced chemodynamic therapy DOI
Shulan Li, Xu Chu, Hongli Dong

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 479, P. 215004 - 215004

Published: Dec. 31, 2022

Language: Английский

Citations

58
Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: novel insights and perspectives DOI Creative Commons
Haiying Wang, Qiao Chu,

Qiutong Guan

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(4), P. 100829 - 100829

Published: July 1, 2023

Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.

Language: Английский

Citations

38
Activatable Graphene Quantum‐Dot‐Based Nanotransformers for Long‐Period Tumor Imaging and Repeated Photodynamic Therapy DOI
Yuqi Yang, Baolong Wang, Xu Zhang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: April 7, 2023

Photodynamic therapy (PDT) is considered as an emerging therapeutic modality against cancer with high spatiotemporal selectivity because the utilized photosensitizers (PSs) are only active and toxic upon light irradiation. To maximize its effectiveness, PDT usually applied repetitively for ablating various tumors. However, total overdose of PSs from repeated administrations causes severe side effects. Herein, acidity-activated graphene quantum dots-based nanotransformers (GQD NT) developed PS vehicles long-period tumor imaging PDT. Under guidance Arg-Gly-Asp peptide, GQD NT targets to tissues actively, then loosens enlarges in acidity, thus promising long retention. Afterwards, transforms into small pieces better penetration tumor. Upon laser irradiation, generates mild hyperthermia that enhances cell membrane permeability further promotes uptake. Most intriguingly, as-prepared not "turns-on" fluorescence/magnetic resonance signals, but also achieves efficient Notably, dose reduced 3.5 µmol kg-1 , which 10-30 times lower than other reported works. Overall, this study exploits a smart vehicle enhance accumulation, retention, release tumors through programmed deformation, overcoming obstacle

Language: Английский

Citations

36