Macromolecular Bioscience,
Journal Year:
2022,
Volume and Issue:
22(7)
Published: April 7, 2022
Abstract
As
the
first
defensive
line
between
human
body
and
outside
world,
skin
is
vulnerable
to
damage
from
external
environment.
Skin
wounds
can
be
divided
into
acute
(mechanical
injuries,
chemical
surgical
wounds,
etc.)
chronic
(burns,
infections,
diabetes,
etc.).
In
order
manage
wound,
a
variety
of
wound
dressings
have
been
developed,
including
gauze,
films,
foams,
nanofibers,
hydrocolloids,
hydrogels.
Recently,
hydrogels
received
much
attention
because
their
natural
extracellular
matrix
(ECM)‐mimik
structure,
tunable
mechanical
properties,
facile
bioactive
substance
delivery
capability.
They
show
great
potential
application
in
repair.
This
paper
introduces
anatomy
function
skin,
process
healing
conventional
dressings,
then
composition
construction
methods
Next,
this
necessary
properties
repair
latest
research
progress
hydrogel
for
Finally,
future
development
goals
materials
field
are
proposed.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
19, P. 360 - 375
Published: April 26, 2022
The
high
demand
for
rapid
wound
healing
has
spurred
the
development
of
multifunctional
and
smart
bioadhesives
with
strong
bioadhesion,
antibacterial
effect,
real-time
sensing,
wireless
communication,
on-demand
treatment
capabilities.
Bioadhesives
bio-inspired
structures
chemicals
have
shown
unprecedented
adhesion
strengths,
as
well
tunable
optical,
electrical,
bio-dissolvable
properties.
Accelerated
been
achieved
via
directly
released
growth
factors,
material
or
drug-induced
host
immune
responses,
delivery
curative
cells.
Most
recently,
integration
biosensing
modules
units
in
a
closed-loop
system
yielded
bioadhesives,
allowing
sensing
physiological
conditions
(e.g.,
pH,
temperature,
uric
acid,
glucose,
cytokine)
iterative
feedback
drastically
enhanced,
stage-specific
by
triggering
drug
to
avoid
infection
prolonged
inflammation.
Despite
advances
burgeoning
field,
challenges
still
exist
design
fabrication
integrated
systems,
particularly
chronic
wounds,
presenting
significant
opportunities
future
next-generation
materials
systems.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 303 - 326
Published: April 18, 2023
Microneedle,
as
a
novel
drug
delivery
system,
has
attracted
widespread
attention
due
to
its
non-invasiveness,
painless
and
simple
administration,
controllable
delivery,
diverse
cargo
loading
capacity.
Although
microneedles
are
initially
designed
penetrate
stratum
corneum
of
skin
for
transdermal
they,
recently,
have
been
used
promote
wound
healing
regeneration
tissues
organs
the
results
promising.
Despite
there
reviews
about
microneedles,
few
them
focus
on
tissue
regeneration.
Here,
we
review
recent
advances
in
this
field.
We
first
give
an
overview
microneedle
system
terms
potential
cargos
(e.g.,
small
molecules,
macromolecules,
nucleic
acids,
nanoparticles,
extracellular
vesicle,
cells),
structural
designs
multidrug
structures,
adhesive
structures),
material
selection,
release
mechanisms.
Then
briefly
summarize
different
fabrication
methods,
including
their
advantages
limitations.
finally
progress
microneedle-assisted
skin,
cardiac,
bone,
tendon,
ocular,
vascular,
oral,
hair,
spinal
cord,
uterine
tissues).
expect
that
our
article
would
serve
guideline
readers
design
systems
according
applications,
structure
design,
achieving
better
efficacy.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(1)
Published: Jan. 21, 2023
Abstract
Global
increasing
demand
for
high
life
quality
and
length
facilitates
the
development
of
tissue
engineering
regenerative
medicine,
which
apply
multidisciplinary
theories
techniques
to
achieve
structural
reconstruction
functional
recovery
disordered
or
damaged
tissues
organs.
However,
clinical
performances
adopted
drugs,
materials,
powerful
cells
in
laboratory
are
inescapably
limited
by
currently
available
technologies.
To
tackle
problems,
versatile
microneedles
developed
as
new
platform
local
delivery
diverse
cargos
with
minimal
invasion.
The
efficient
delivery,
well
painless
convenient
procedure
endow
good
patient
compliance
clinic.
In
this
review,
we
first
categorize
different
microneedle
systems
models,
then
summarize
their
applications
medicine
mainly
involving
maintenance
rehabilitation
end,
discuss
advantages,
challenges,
prospects
depth
future
translations.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(4)
Published: Jan. 27, 2023
Interruption
of
the
wound
healing
process
due
to
pathogenic
infection
remains
a
major
health
care
challenge.
The
existing
methods
for
management
require
power
sources
that
hinder
their
utilization
outside
clinical
settings.
Here,
next
generation
wearable
self-powered
dressing
is
developed,
which
can
be
activated
by
diverse
stimuli
from
patient’s
body
and
provide
on-demand
treatment
both
normal
infected
wounds.
highly
tunable
composed
thermocatalytic
bismuth
telluride
nanoplates
(Bi
2
Te
3
NPs)
functionalized
onto
carbon
fiber
fabric
electrodes
triggered
surrounding
temperature
difference
controllably
generate
hydrogen
peroxide
effectively
inhibit
bacterial
growth
at
site.
integrated
are
connected
triboelectric
nanogenerator
(TENG)
electrical
stimulation
accelerated
closure
enhancing
cellular
proliferation,
migration,
angiogenesis.
reported
holds
great
potential
in
facilitating
personalized
user-friendly
with
improved
outcomes.
ACS Applied Bio Materials,
Journal Year:
2022,
Volume and Issue:
5(9), P. 4055 - 4085
Published: Aug. 18, 2022
Currently,
the
clinic's
treatment
of
acute/chronic
wounds
is
still
unsatisfactory
due
to
lack
functional
and
appropriate
wound
dressings.
Intelligent
multifunctional
dressings
are
considered
most
advanced
modalities.
It
essential
design
develop
with
required
functions
according
microenvironment
in
clinical
treatment.
This
work
summarizes
characteristics
various
common
wounds,
such
as
acute
wound,
diabetic
burns
scalded
mucosal
ulcers
wound.
Furthermore,
factors
transformation
from
chronic
were
analyzed.
Then
we
focused
on
summarizing
how
researchers
fully
thoroughly
combined
complex
modern
technology
ensure
usability
value
dressing,
photothermal-sensitive
dressings,
dressing
(pH-sensitive
ROS-sensitive
osmotic
pressure
dressings),
hemostatic
guiding
tissue
regeneration
microneedle
3D/4D
printing
Finally,
revolutionary
development
transform
existing
into
needs
soon
possible
have
carried
out
a
reasonable
meaningful
outlook.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(12), P. 3091 - 3116
Published: Jan. 1, 2023
This
work
reviewed
the
new
progress
of
conductive
hydrogels
in
application
tissue
repair
and
provided
a
useful
reference
for
further
preparation
safer
more
efficient
engineering.
