Emerging carbon-supported single-atom catalysts for biomedical applications

Matter, Journal Year: 2022, Volume and Issue: 5(10), P. 3341 - 3374

Published: Oct. 1, 2022

Language: Английский

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Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation To Enhance Chemodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(12)

Published: Jan. 28, 2023

Abstract Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there no study exploring effect cell membrane unsaturation degree on CDT. Here, we report a self‐reinforcing CDT agent (denoted as OA@Fe‐SAC@EM NPs), consisting oleanolic acid (OA)‐loaded iron single‐atom catalyst (Fe‐SAC)‐embedded hollow carbon nanospheres encapsulated by an erythrocyte (EM), which promotes LPO improve efficacy via modulating unsaturation. Upon uptake NPs cancer cells, Fe‐SAC‐catalyzed conversion endogenous hydrogen peroxide into hydroxyl radicals, addition initiating therapeutic process, causes dissociation EM shell and ensuing release OA can enrich cellular membranes with PUFAs, enabling amplification‐enhanced

Language: Английский

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Enhancing Catalytic Activity of a Nickel Single Atom Enzyme by Polynary Heteroatom Doping for Ferroptosis-Based Tumor Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 3064 - 3076

Published: Jan. 16, 2023

As a rising generation of nanozymes, single atom enzymes show significant promise for cancer therapy, due to their maximum utilization efficiency and well-defined electronic structures. However, it remains tremendous challenge precisely produce heteroatom-doped enzyme with an expected coordination environment. Herein, we develop anion exchange strategy controlled production edge-rich sulfur (S)- nitrogen (N)-decorated nickel (S-N/Ni PSAE). In particular, sulfurized S-N/Ni PSAE exhibits stronger peroxidase-like glutathione oxidase-like activities than the nitrogen-monodoped enzyme, which is attributed vacancies defective sites atoms. Moreover, both in vitro vivo results demonstrate that, compared N/Ni PSAE, more effectively triggers ferroptosis tumor cells via inactivating peroxidase 4 inducing lipid peroxidation. This study highlights enhanced catalytic efficacy polynary ferroptosis-based therapy.

Language: Английский

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Recent advances in the development and analytical applications of oxidase-like nanozymes

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 166, P. 117220 - 117220

Published: Aug. 3, 2023

Language: Английский

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Ferroptosis: a double-edged sword mediating immune tolerance of cancer

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(11)

Published: Nov. 5, 2022

Abstract The term ferroptosis was put forward in 2012 and has been researched exponentially over the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed cell death, which belongs to a type necrosis distinguished from apoptosis autophagy. Actuated by phospholipid peroxidation, modulated various cellular metabolic signaling pathways, including amino acid, lipid, iron, mitochondrial metabolism. Notably, associated with numerous diseases plays double-edged sword role. Particularly, metastasis-prone or highly-mutated tumor cells are sensitive ferroptosis. Hence, inducing prohibiting vastly promising potential treating drug-resistant cancers. Immunotolerant cancer not traditional death pathway such as necroptosis, while crucial role mediating immune antagonize tolerance, broad prospects clinical setting. Herein, we summarized mechanisms delineated regulatory network ferroptosis, emphasized its dual proposed significant benefits microenvironment, ultimately presented some provocative doubts. This review aims provide practical guidelines research directions for practice immune-resistant tumors.

Language: Английский

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Tumor Microenvironment Responsive Hollow Nanoplatform for Triple Amplification of Oxidative Stress to Enhance Cuproptosis‐Based Synergistic Cancer Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(13)

Published: Jan. 30, 2023

Cuproptosis is a recently discovered form of programmed cell death and shows great potential in cancer treatment. Herein, copper-dithiocarbamate chelate-doped artemisinin-loaded hollow nanoplatform (HNP) developed via chelation competition-induced hollowing strategy for cuproptosis-based combination therapy. The HNP exhibits tumor microenvironment-triggered catalytic activity, wherein liberated Cu2+ catalyzes artemisinin endogenous H2 O2 to produce C-centered radicals hydroxyl radicals, respectively. Meanwhile, the disulfide bonds-rich can deplete intracellular glutathione, thus triply amplifying oxidative stress. augmented stress sensitizes cells cuproptosis, causing prominent dihydrolipoamide S-acetyltransferase oligomerization mitochondrial dysfunction. Moreover, activate ferroptosis inhibiting GPX4 activity trigger apoptosis dithiocarbamate-copper chelate-mediated ubiquitinated proteins accumulation, resulting potent antitumor efficacy. Such cuproptosis/ferroptosis/apoptosis synergetic opens new avenue

Language: Английский

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Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications

Small, Journal Year: 2023, Volume and Issue: 19(30)

Published: April 14, 2023

Abstract Nanomaterials with enzyme‐mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing their remarkable advantages, such high stability, easy preparation, and favorable catalytic performance. Recently, the rapid development of nanotechnology characterization techniques, single atom nanozymes (SAzymes) atomically dispersed active sites, well‐defined electronic geometric structures, tunable coordination environment, maximum metal utilization developed exploited. With superior performance selectivity, SAzymes have made impressive progress in biomedical applications expected bridge gap between artificial enzymes. Herein, recent advances SAzyme preparation methods, mechanisms, systematically summarized. Their cancer therapy, oxidative stress cytoprotection, antibacterial biosensing discussed depth. Furthermore, appreciate these advances, main challenges, prospects for future also outlined highlighted this review.

Language: Английский

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Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: Feb. 27, 2023

With the threat posed by drug-resistant pathogenic bacteria, developing non-antibiotic strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is a newly discovered form of regulated cell death that can overcome drug resistance. Emerging evidence shows potential triggering ferroptosis-like antibacterial therapy, but direct delivery iron species inefficient and may cause detrimental effects. Herein, an effective strategy to induce bacterial nonferrous coordinating single-atom metal sites (e.g., Ir Ru) into sp

Language: Английский

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Self‐Driven Electricity Modulates d‐Band Electrons of Copper Single‐Atom Nanozyme for Boosting Cancer Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(48)

Published: July 21, 2023

Abstract Single‐atom nanozymes (SAzymes) are considered as the most promising candidates for natural enzymes due to their atomically dispersed active sites that closely resemble metal centers of counterparts. However, a significant challenge still exists improving catalytic activities, retarding practical applications. Herein, this article presents through application human self‐driven triboelectric device impose electrical stimulus, multiple enzyme‐like activities single‐atom copper nanozyme (Cu‐NC) remarkably improved, thereby boosting cancer cell oxidative damage and death realizing improved therapy. Under an stimulus with 20 V voltage, peroxidase, catalase, oxidase, glutathione oxidase like Cu‐NC all boost generation free radicals. Through calculation, work analyzes how modulates activity via decreasing adsorption energy H 2 O on Cu sites, increasing d xy orbital near Fermi level, shifting d‐band center Cu, facilitating reactions. This opens new perspectives nanoenzymes

Language: Английский

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In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 11, 2024

Abstract Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, wide application GPX4 in therapy is hampered due to poor delivery efficacy and nonspecific ferroptosis. Taking advantage vivo self-assembly, we develop peptide-ferriporphyrin conjugate with microenvironment specific improve penetration, endocytosis inhibition, ultimately enhancing its anticancer activity via Briefly, inhibitory peptide conjugated an assembled linker decorated pH-sensitive moiety ferriporphyrin produce ( Gi-F-CAA ). Under acidic tumor, self-assembles into large nanoparticles (Gi-F) enhanced hydrophobic interaction after hydrolysis CAA, improving efficiency. Importantly, Gi-F exhibits substantial inhibition assembly binding AEB ) effect, augmenting oxidative stress ferriporphyrin-based Fenton reaction, enabling antitumor properties multiple models. Our findings suggest this design effect can induction ferroptosis, providing alternative overcoming chemoresistance.

Language: Английский

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