Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(45)
Published: July 19, 2023
Organic
phototheranostics
simultaneously
having
fluorescence
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window,
and
photothermal
photodynamic
functions
possess
great
prospects
tumor
diagnosis
therapy.
However,
such
generally
suffer
from
low
brightness
poor
performance
due
to
severe
solvatochromism.
Herein,
an
organic
NIR-II
fluorophore
AS1,
which
possesses
inverted
dependence
of
quantum
yield
on
polarity,
is
reported
serve
as
potent
for
After
encapsulation
AS1
into
nanostructures,
obtained
(AS1R
)
exhibit
high
extinction
coefficients
(e.g.,
68200
L
mol-1
cm-1
at
808
nm),
emission
with
up
4.7%
beyond
1000
nm,
conversion
efficiency
≈65%,
1
O2
4.1%.
The
characterization
photophysical
properties
demonstrates
that
AS1R
superior
other
types
brightness,
effect,
same
mass
concentration.
excellent
phototheranostic
enables
clear
visualization
complete
elimination
tumors
using
a
single
injection
dose.
This
study
merits
polarity
high-performance
agents
imaging
phototherapy
tumors.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(20), P. 13019 - 13034
Published: May 9, 2024
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
possess
different
merits
in
cancer
phototherapy,
but
the
tumor
microenvironment
becomes
unfavorable
during
phototheranostic
progress.
Herein,
we
report
a
self-adaptive
cyanine
derivative
Cy5-TPA
with
PDT-dominated
state
to
PTT-dominated
autoswitch
feature
for
enhanced
photoimmunotherapy.
The
incorporation
of
rotatable
triphenylamine
(TPA)
moiety
renders
temperature
or
intramolecular-motion
regulated
photoactivities,
which
shows
preferable
reactive
oxygen
species
(ROS)
generation
at
lower
while
stronger
conversion
higher
ones.
Such
promising
permits
situ
switch
from
along
intratumoral
increase
laser
irradiation,
also
works
line
concurrently
reduced
level,
exhibiting
phototherapeutic
behavior
maximize
antitumor
outcome.
Most
importantly,
facilitates
sequential
release
damage-associated
molecular
patterns
immunogenic
cell
death
(ICD).
Hence,
demonstrates
excellent
photoimmunotherapy
performance
ICD
induction,
dendritic
maturation,
T
activation
eradication
metastasis
inhibition.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(15)
Published: Feb. 16, 2024
Developing
Type-I
photosensitizers
provides
an
attractive
approach
to
solve
the
dilemma
of
inadequate
efficacy
photodynamic
therapy
(PDT)
caused
by
inherent
oxygen
consumption
traditional
Type-II
PDT
and
anoxic
tumor
microenvironment.
The
challenge
for
exploration
PSs
is
facilitate
electron
transfer
ability
photosensitization
molecules
transforming
or
H
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: Feb. 15, 2024
Abstract
Photoactivatable
molecules,
with
high‐precision
spatialtemporal
control,
have
largely
promoted
bioimaging
and
phototherapy
applications
of
fluorescent
dyes.
Here,
the
first
photoactivatable
sensor
(
BI
)
is
described
that
can
be
triggered
by
broad
excitation
light
(405–660
nm),
which
further
undergoes
intersystem
crossing
H‐atom
transfer
processes
to
forming
superoxide
anion
radicals
(O
2
−•
carbon
radicals.
Particularly,
photoinduced
gain
carbon‐centered
BI•
allows
for
radical‐radical
coupling
afford
combined
crosslink
product
BI─BI
),
would
oxidized
in
presence
O
produce
an
extended
conjugate
system
near
infrared
emission
(820
nm).
Besides,
photochemically
generated
Cy─BI
possesses
ultra‐high
photothermal
conversion
efficiency
up
90.9%,
optimized
potential.
What′s
more,
Western
Blot
assay
reveals
both
photoproduct
efficiently
inhibit
expression
CHK1,
irradiation
induces
apoptosis
ultimately
enhances
phototherapeutic
effects.
Thus,
combination
cell
cycle
block
inducing
apoptosis,
photodynamic
therapy
treatments
significantly
suppress
solid
tumor
vivo
antitumor
efficacy
explorations.
This
a
novel
finding
developing
as
well
applicability
photoimaging
tumor‐related
areas.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(37), P. 25671 - 25684
Published: Sept. 3, 2024
Combined
photodynamic
and
photothermal
therapy
(PDT
PTT)
can
achieve
more
superior
therapeutic
effects
than
the
sole
mode
by
maximizing
photon
utilization,
but
there
remains
a
significant
challenge
in
development
of
related
single-molecule
photosensitizers
(PSs),
particularly
those
with
type
I
photosensitization.
In
this
study,
self-assembly
squaraine
dyes
(SQs)
is
shown
to
be
promising
strategy
for
designing
PSs
combined
PDT
PTT,
supramolecular
PS
(TPE-SQ7)
has
been
successfully
developed
through
subtle
molecular
design
an
indolenine
SQ,
which
self-assemble
into
highly
ordered
H-aggregates
aqueous
solution
as
well
nanoparticles
(NPs).
contrast
typical
quenching
effect
on
reactive
oxygen
species
(ROS)
generation,
our
results
encouragingly
manifest
that
enhance
ROS
(
Aggregate,
Journal Year:
2022,
Volume and Issue:
3(6)
Published: Oct. 24, 2022
Abstract
Organic
luminescent
materials
are
one
of
the
research
hotspots
worldwide.
The
efficiency
these
can
be
tuned
by
introducing
noncovalent
interactions.
Ion−π
interactions,
mainly
including
anion−π
interactions
and
cation−π
relatively
new
but
powerful
with
extensive
applications
in
supramolecular
chemistry.
use
ion−π
to
fabricate
highly
is
initiated
since
they
were
introduced
develop
aggregation‐induced
emission
luminogens
2017.
Then,
this
field
undergoing
through
challenging
very
prospective
developments.
In
minireview,
we
start
a
brief
introduction
then
make
summary
reports
on
organic
fluorescence
based
room
temperature
phosphorescence
induced
bioimaging,
imaging‐guided
anticancer
antibacterial
treatment
also
discussed.
challenges
prospects
using
for
constructing
presented
final
part.
It
expected
that
minireview
will
provide
some
guidelines
fabricating
novel
further
extend
application
potential
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(50)
Published: Oct. 18, 2022
The
performances
of
second
near-infrared
(NIR-II)
organic
phototheranostic
agents
(OPTAs)
depend
on
both
molecular
structure
and
packing
when
used
as
nanoparticles
(NPs).
Herein,
we
proposed
a
facile
structural
isomerization-induced
3D
spatial
donor
(D)-acceptor
(A)
interlocked
network
for
achieving
NIR-II
OPTAs.
Two
isomers,
4MNVDPP
6MNVDPP
were
synthesized
formulated
into
NPs.
6MNVDPP,
which
has
larger
electrostatic
potential
difference,
exhibits
compact
D-A
in
the
crystal
form,
while
forms
2D
D-D
type
J-aggregates.
Thus,
NPs
show
red-shifted
NIR
absorption
molar
extinction
coefficient
than
Thanks
to
typical
emission,
superior
photothermal-stability,
high
photothermal
conversion
efficiency
(89
%)
reactive
oxygen
species
production
capacity,
exhibit
outstanding
tiny
capillary
vasculature/tumor
imaging
ability
synergistic
photothermal/photodynamic
anti-cancer
effect
vivo.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(44), P. 49582 - 49591
Published: Oct. 26, 2022
Hydrogel
has
been
widely
used
in
modern
biotherapeutics
due
to
its
excellent
biocompatibility,
degradability,
and
high
drug
loading
capacity.
Among
them,
the
construction
of
a
phototherapy
system
including
photosensitizer
hydrogel
aroused
great
interest
tumor
therapy.
Unfortunately,
complex
modifications
are
necessary
integrate
different
photosensitizers
into
hydrogel.
In
this
work,
an
injectable
was
proposed
by
Schiff
base
reaction
between
HA-CHO
carbon
dots
(CDs),
which
can
realize
PTT
simultaneously.
Notably,
CDs
with
rich
−NH2
be
not
only
as
but
also
efficient
cross-linking
agent
for
form
network.
The
CD@Hydrogel
outstanding
biosafety
showed
antitumor
effect
after
660
nm
laser
irradiation
vitro
vivo
experiments.
summary,
PDT
synergistic
treatment
under
one
light
source
act
react
hydrogel,
is
simple
efficient,
providing
new
strategy
cancer
phototherapy.
