Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)

Published: Jan. 31, 2023

Antimicrobial resistance (AMR) is one of the biggest threats to environment and health. AMR rapidly invalidates conventional antibiotics, antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several show AMR-independent effects without detectable new therefore suggested prevent evolution. In contrast, some are found trigger evolution AMR. Given these seemingly conflicting findings, a timely discussion two faces urgently needed. This review systematically compares killing mechanisms structure-activity relationships antibiotics nanomaterials. We then focus on nano-microbe interactions elucidate impacts molecular initiating events Finally, we provide an outlook future propose design principles for prevention

Language: Английский

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MOFs and MOF-Derived Materials for Antibacterial Application

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(4), P. 215 - 215

Published: Nov. 3, 2022

Bacterial infections pose a serious threat to people’s health. Efforts are being made develop antibacterial agents that can inhibit bacterial growth, prevent biofilm formation, and kill bacteria. In recent years, materials based on metal organic frameworks (MOFs) have attracted significant attention for various applications due their high specific surface area, enzyme-like activity, continuous release of ions. This paper reviews the progress MOFs as agents, focusing preparation methods, fundamental mechanisms, strategies enhance effects. Finally, several prospects related application proposed, aiming provide possible research directions in this field.

Language: Английский

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Functional Metal–Organic Frameworks for Maximizing Transconductance of Organic Photoelectrochemical Transistor at Zero Gate Bias and Biological Interfacing Application

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(22)

Published: Feb. 21, 2023

Abstract Organic electrochemical transistors showing maximum transconductance ( g m ) at zero gate bias V G is desired but has long been a challenge. To date, few solutions to this issue are available. Light‐matter interplay shown as rich sources for optogenetics, photodynamic therapy, and advanced electronics, its potential in modulation largely untapped. Herein, the challenge addressed by unique light‐matter newly emerged technique of organic photoelectrochemical transistor (OPECT), which exemplified dual‐ligand photosensitive metal–organic frameworks (DL‐PS‐MOFs)/TiO 2 nanorods (NRs) gated poly(ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) OPECT under 425 nm light irradiation. Interestingly, stimulation on DL‐PS‐MOFs can de‐dope PEDOT:PSS with altered physics, achieving device simultaneous superior output channel current. In connection cascade catalytic hairpin assembly‐rolling circle amplification strategy, such then biologically interfaced miRNA‐triggered growth DNA spheres sensitive detection miRNA‐21 down 0.12 f . This work features proof‐of‐concept study using enable biological interfacing application.

Language: Английский

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MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: March 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Language: Английский

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Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14085 - 14122

Published: May 22, 2024

Infectious diseases pose a serious threat and substantial economic burden on global human public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless their antibiotic susceptibility. contrast conventional therapies, these approaches facilitate precise targeting pathogenic and/or infectious microenvironments, effectively minimizing toxicity mammalian cells surrounding healthy tissues. The highlighted include photodynamic therapy, photocatalytic photothermal endogenous pigments-based photobleaching polyphenols-based photo-oxidation therapy. comprehensive exploration aims offer updated information development effective, convenient, safe, alternative counter growing MDR future.

Language: Английский

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Metal–organic frameworks in drug delivery: engineering versatile platforms for therapeutic applications

RSC Advances, Journal Year: 2024, Volume and Issue: 14(41), P. 30201 - 30229

Published: Jan. 1, 2024

Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design specific features such surface area pore size, encapsulation within not only improves their stability solubility but also allows controlled release kinetics, which therapeutic efficacy minimizes adverse effects. Furthermore, it discusses challenges potential advantages MOF-based delivery, MOF stability, biocompatibility, scale-up production. With further advancements in synthesis, functionalization techniques, understanding interactions using biological systems, can significant promise expanding medicine improving patient outcomes.

Language: Английский

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Ag-decorated multivariate metal-organic frameworks for enhanced sonodynamic therapy of bacterial infections in wound healing

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102181 - 102181

Published: Feb. 14, 2024

Language: Английский

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MOFs and bone: Application of MOFs in bone tissue engineering and bone diseases

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(7), P. 107986 - 107986

Published: Nov. 6, 2022

Language: Английский

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Multiporphyrinic architectures: Advances in structural design for photodynamic therapy

Aggregate, Journal Year: 2023, Volume and Issue: 5(1)

Published: Sept. 13, 2023

Abstract Rationally designed multiporphyrinic architectures for boosting photodynamic therapy (PDT) have attracted significant attentions recently years due to their great potential light‐mediated generation of reactive oxygen species. However, there is still a gap between the structure design and PDT performance biomedical applications. This tutorial review provides historical overview on (i) basic concept deeply understanding porphyrin‐mediated reactions, (ii) developing strategies constructing porphyrinic architectures, like nanorings, boxes, metal‐organic frameworks (MOFs), covalent‐organic (COFs), vesicles, etc., where we classified into following three categories: multiporphyrin arrays, frameworks, others porphyrin assemblies, (iii) various application scenarios clinical cancer antibacterial infection. Also, existing challenges future perspectives innovation applications are mentioned in end section. Moreover, nanomaterials with atomically precise provide an ideal platform investigating relationship structures outputs, personalized “all‐in‐one” theranostic agents, popularization wider fields.

Language: Английский

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Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria

Chemical Science, Journal Year: 2023, Volume and Issue: 14(18), P. 4863 - 4871

Published: Jan. 1, 2023

Type I photosensitizers (PSs) with an aggregation-induced emission (AIE) feature have received sustained attention for their excellent theranostic performance in the treatment of clinical diseases. However, development AIE-active type PSs strong reactive oxygen species (ROS) production capacity remains a challenge due to lack in-depth theoretical studies on aggregate behavior and rational design strategies. Herein, we proposed facile oxidization strategy enhance ROS generation efficiency PSs. Two AIE luminogens, MPD its oxidized product MPD-O were synthesized. Compared MPD, zwitterionic showed higher efficiency. The introduction electron-withdrawing atoms results formation intermolecular hydrogen bonds molecular stacking MPD-O, which endowed more tightly packed arrangement state. Theoretical calculations demonstrated that accessible intersystem crossing (ISC) channels larger spin-orbit coupling (SOC) constants provide further explanation superior evidenced effectiveness enhancing ability by strategy. Moreover, DAPD-O, cationic derivative was synthesized improve antibacterial activity showing photodynamic against methicillin-resistant S. aureus both vitro vivo. This work elucidates mechanism offers new guideline exploitation

Language: Английский

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