Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(1), P. 15 - 15
Published: Jan. 6, 2025
Biomimetic
nanodrug
delivery
systems
based
on
cell
membranes
have
emerged
as
a
promising
approach
for
targeted
cancer
therapy
due
to
their
biocompatibility
and
low
immunogenicity.
Among
them,
platelet-mediated
are
particularly
noteworthy
innate
tumor-homing
interaction
capabilities.
These
utilize
nanoparticles
shielded
directed
by
platelet
membrane
coatings
efficient
drug
delivery.
This
review
highlights
the
role
of
platelets
in
therapy,
summarizes
advancements
platelet-based
systems,
discusses
integration
with
other
treatments.
Additionally,
it
addresses
limitations
challenges
delivery,
offering
insights
into
future
developments
this
innovative
field.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(15)
Published: March 26, 2023
Abstract
The
regulation
of
tumor
immunosuppressive
microenvironments
via
precise
drug
delivery
is
a
promising
strategy
for
preventing
recurrence
and
metastasis.
Inspired
by
the
stealth
strategy,
stealthy
nanovehicle
based
on
neutrophil
camouflage
developed
to
achieve
immunotherapy
triggering
pyroptosis.
comprises
anti‐CD11b‐
IR820‐conjugated
bovine
serum
albumin
nanoparticles
loaded
with
decitabine.
Camouflaged
neutrophils,
nanovehicles
efficient
hitchhiking
owing
biotropism
neutrophils
tumors.
fluorescent
signal
molecule,
IR820,
acts
as
navigation
monitor
track
nanovehicle.
released
decitabine
upregulates
gasdermin
E,
laser
irradiation
activates
caspase‐3,
thereby
resulting
in
pyroptosis,
which
improves
system's
adaptive
immune
response.
In
triple‐negative
breast
cancer
animal
model,
it
regulates
microenvironment
effective
induces
long‐lasting
strong
memory
prevent
lung
Photodiagnosis and Photodynamic Therapy,
Journal Year:
2024,
Volume and Issue:
45, P. 103959 - 103959
Published: Jan. 21, 2024
Breast
cancer
(BC)
remains
an
enigmatic
fatal
modality
ubiquitously
prevalent
in
different
parts
of
the
world.
Contemporary
medicines
face
severe
challenges
remediating
and
healing
breast
cancer.
Due
to
its
spatial
specificity
nominal
invasive
therapeutic
regime,
photothermal
therapy
(PTT)
has
attracted
much
scientific
attention
down
lane.
PTT
utilizes
a
near-infrared
(NIR)
light
source
irradiate
tumor
target
intravenously
or
non-invasively,
which
is
converted
into
heat
energy
over
optical
fibre.
Dynamic
progress
nanomaterial
synthesis
was
achieved
with
specialized
visual,
physicochemical,
biological,
pharmacological
features
make
up
for
inadequacies
expand
horizon
PTT.
Numerous
nanomaterials
have
substantial
NIR
absorption
can
function
as
efficient
transducers.
It
achievable
limit
wavelength
range
absorbance
peak
specific
by
manipulating
their
synthesis,
enhancing
precision
quality
Along
same
lines,
various
are
conjugated
wide
surface-modifying
chemicals,
including
polymers
antibodies,
may
modify
persistence
diminish
toxicity
concerns.
In
this
article,
we
tend
put
forth
insights
fundamental
conceptualizations
on
pre-existing
advances
upon
conjugation
biocompatible
working
synergy
combat
cancer,
encompassing
several
strategies
like
immunotherapy,
chemotherapy,
photodynamic
therapy,
radiotherapy
coupled
Additionally,
role
mechanisms
nanoparticles,
well
possible
alternatives
PTT,
summarized
distinctive
integral
aspect
article.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: May 25, 2024
Acute
wounds
are
converted
to
chronic
due
advanced
age
and
diabetic
complications.
Nanozymes
catalyze
ROS
production
kill
bacteria
without
causing
drug
resistance,
while
microneedles
(MNs)
can
break
through
the
skin
barrier
deliver
drugs
effectively.
be
intergrateded
into
MNs
delivery
systems
improve
painless
delivery.
It
also
reduce
effective
dose
of
sterilization
increasing
efficiency
effectively
killing
wounded
preventing
resistance.
This
paper
describes
various
types
metal
nanozymes
from
previous
studies
compares
their
mutual
enhancement
with
nanozymes.
The
pooled
results
show
that
MNs,
material
innovation,
able
both
penetrate
scab
exert
additional
anti-inflammatory
bactericidal
effects.
catalytic
effect
some
accelerate
lysis
or
create
a
cascade
reaction
against
inflammation
infection.
However,
issue
increased
toxicity
associated
penetration
clinical
translation
remains
challenge.
study
reviews
latest
published
corresponding
challenges
use
combined
for
treatment
wounds,
providing
further
information
future
research.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(6), P. 4981 - 4992
Published: Jan. 9, 2024
During
wound
healing
after
cancer
surgery,
platelets,
neutrophils,
and
macrophages
accumulate
at
the
site
induce
important
pathophysiological
features.
Utilizing
these
features,
development
of
targeted
delivery
systems
for
postoperative
tumor
immunotherapy
is
an
strategy.
Herein,
a
twindrive
precise
system
hybrid
membrane
combined
with
CD47
blocking
developed
regulation
to
immunotherapy.
The
consists
IR820-modified
platelet-neutrophil
membranes
loaded
R848
nanoparticles.
Based
on
pathological
characteristics
platelet
aggregation
neutrophil
tendency
caused
by
inflammatory
microenvironment
could
achieve
immune
drugs
sites.
After
guided
fluorescence
imaging,
reprogram
M2
into
M1
macrophages,
stimulate
dendritic
cell
maturation
as
adjuvant,
then
activate
T
immunity.
polarization
blockade
together
enhanced
phagocytosis
function
which
cell-mediated
cellular
response
finally
effectively
inhibit
postsurgical
recurrence,
metastasis,
prolonged
survival
time.
It
develops
regulatory
cell-specific
responses
features
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
21, P. 1 - 19
Published: Aug. 10, 2022
Although
nano-immunotherapy
has
advanced
dramatically
in
recent
times,
there
remain
two
significant
hurdles
related
to
immune
systems
cancer
treatment,
such
as
(namely)
inevitable
elimination
of
nanoplatforms
and
severely
immunosuppressive
microenvironment
with
low
immunogenicity,
hampering
the
performance
nanomedicines.
To
address
these
issues,
several
immune-regulating
camouflaged
nanocomposites
have
emerged
prevailing
strategies
due
their
unique
characteristics
specific
functionalities.
In
this
review,
we
emphasize
composition,
performances,
mechanisms
various
nanoplatforms,
including
polymer-coated,
cell
membrane-camouflaged,
exosome-based
evade
clearance
or
upregulate
function
against
tumor.
Further,
discuss
applications
directly
boosting
immunotherapy
some
immunogenic
death-inducing
immunotherapeutic
modalities,
chemotherapy,
photothermal
therapy,
reactive
oxygen
species-mediated
immunotherapies,
highlighting
current
progress
advancements.
Finally,
conclude
article
interesting
perspectives,
suggesting
future
tendencies
innovative
constructs
towards
translation
pipeline.
