Photothermal Enhanced and Tumor Microenvironment Responsive Nanozyme for Amplified Cascade Enzyme Catalytic Therapy

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(7)

Published: Nov. 26, 2022

Nanocatalysts, a class of nanomaterials with intrinsic enzyme-like activities, have been widely investigated for cancer catalytic therapy in recent years. However, precise construction nanocatalysts excellent enzyme activity and biosafety tumor still remains challenging. Here, biodegradable nanocatalyst, PEGylated Cux Mny Sz (PCMS), is reported that can promote cascade reactions microenvironment (TME) while confining off-target side effects on normal tissues. PCMS not only catalyzes the conversion endogenous hydrogen peroxide (H2 O2 ) to oxygen (O2 via catalase-like then superoxide radical (·O2- oxidase-like TME, but also effectively depletes intracellular glutathione activity. The reactions, by taking advantage high H2 level cells, result an enhanced effect generation ·O2- . More importantly, exhibits prominent photothermal under NIR-II 1064 nm laser irradiation further enhance chemodynamic (CDT) efficacy tumors. In addition, biodegradation TME are beneficial magnetic resonance imaging, photoacoustic imaging infrared thermal resulting tracing fate vivo. This study provides new tool rational design TME-responsive biocompatibility therapy.

Language: Английский

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Ag-Doped Metal–Organic Frameworks’ Heterostructure for Sonodynamic Therapy of Deep-Seated Cancer and Bacterial Infection

ACS Nano, Journal Year: 2022, Volume and Issue: 17(2), P. 1174 - 1186

Published: Dec. 30, 2022

Metal–organic frameworks (MOF) have attracted great potential in sonodynamic therapy (SDT) owing to large sonosensitizers' loading and fast reactive oxygen species' (ROS) diffusion; however, the low ligand-to-metal charge transfer efficiency sharply impairs SDT effect. Herein, we report design of MIL@Ag heterostructures with high electron–hole pairs separation enhanced diverse ROS generation ability for deep-seated cancer treatment bacterial infection. The heterostructure is composed Ti-based MOFs (named MIL), on which are situ assembled silver nanoparticles (Ag NPs). electrochemical experiments density functional theory calculations verify that introduction Ag NPs can significantly improve electron O2 adsorption capacity MIL. Under ultrasound irradiation, doped trap activated electrons from MIL reduce surrounding produce superoxide radicals (•O2–), while holes enable oxidizing H2O hydroxyl (•OH). Thus, they efficiently therapeutic SDT. MIL@Ag-PEG-mediated implements A549 cells' killing under a tissue barrier 2 cm eradicates infection Staphylococcus aureus, thus promoting wound healing. Therefore, MIL@Ag-PEG provides promising strategy augmenting performance by rational sonosensitizers.

Language: Английский

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Sonodynamic therapy combined with phototherapy: Novel synergistic strategy with superior efficacy for antitumor and antiinfection therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 359, P. 188 - 205

Published: June 8, 2023

Language: Английский

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Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 194, P. 114709 - 114709

Published: Jan. 20, 2023

Atherosclerosis, a chronic cardiovascular disease caused by plaque development in arteries, remains leading cause of morbidity and mortality. Atherosclerotic plaques are characterized the expression regulation key molecules such as cell surface receptors, cytokines, signaling pathway proteins, potentially facilitating precise diagnosis treatment on molecular level specifically targeting characteristic molecules. In this review, we highlight recent progress past five years developing molecularly targeted nanomedicine for imaging detection atherosclerosis with use inorganic nanoparticles. Through delivery contrast nanoparticles to specific atherogenesis, atherosclerotic at different stages could be identified monitored via various modalities. We also review therapeutic approaches that target regulate associated lipid regulation, inflammation, apoptosis. The is concluded discussion current challenges future treatment.

Language: Английский

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Nanomedicine for Diagnosis and Treatment of Atherosclerosis

Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)

Published: Oct. 28, 2023

Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.

Language: Английский

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Near-infrared-II-activatable sulfur-deficient plasmonic Bi2S3-x-Au heterostructures for photoacoustic imaging-guided ultrasound enhanced high performance phototherapy

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 644, P. 437 - 453

Published: April 25, 2023

Language: Английский

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2D Cobalt Oxyhydroxide Nanozymes Inhibit Inflammation by Targeting the NLRP3 Inflammasome

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(27)

Published: April 19, 2023

Abstract Nucleotide‐binding domain and leucine rich repeat family pyrin containing 3 (NLRP3) inflammasomes are implicated in diverse inflammatory diseases, so their activation needs to be tightly controlled. Over generation of reactive oxygen species (ROS) is a key factor NLRP3 inflammasome activation. Consequently, nanozymes with ROS scavenging ability potential inhibitors promising therapeutic agents for related diseases. Herein, type 2D cobalt hydroxide oxide nanosheets (Co NSs), nanozyme excellent multienzyme‐like activity, possessing peroxidase (POD), catalase (CAT), superoxide dismutase (SOD) activities, exhibits superior properties protects cells from oxidative damage. Density functional theory (DFT) calculations further reveal these enzyme‐like catalytic reactions eliminating spontaneous CAT dominant under physiological conditions. Performing multienzyme properties, Co NSs present anti‐inflammation activity by blocking oligomerization ASC speck formation, thereby inhibiting assembly Importantly, treatment attenuates the severity LPS‐induced systemic inflammation DSS‐induced colitis. This study highlights successful strategy utilizing cobalt‐based scavenge provides valuable insights into underlying mechanism, demonstrating effects prevention NLRP3‐associatied

Language: Английский

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Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

Exploration, Journal Year: 2023, Volume and Issue: 4(3)

Published: Dec. 7, 2023

Abstract Atherosclerosis, a chronic disease associated with metabolism, poses significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds potential deliver highly effective therapeutic outcomes. These can target and bind specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances various ligand‐modified nanoparticle systems targeting by specifically signature molecules hope precise treatment at molecular level concludes discussion challenges prospects this field. The intention review is inspire novel concepts design advancement targeted nanomedicines tailored atherosclerosis.

Language: Английский

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A Near-Infrared-II Fluorescent Nanocatalyst for Enhanced CAR T Cell Therapy against Solid Tumor by Immune Reprogramming

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11749 - 11763

Published: June 15, 2023

Chimeric antigen receptor (CAR) T cell therapy holds great promise in the treatment of hematological malignancies but performs poorly solid tumors due to tumor immunosuppressive microenvironment. Herein, a multifunctional nanocatalyst (APHA@CM) was prepared by encapsulating horseradish peroxidase (HRP)-loaded Au/polydopamine nanoparticles (Au/PDA NPs) and Ag2S quantum dots with CAR membranes improve tumors. The APHA@CM has excellent multimodal imaging capability precisely guide scope time window for nanocatalyst-induced microenvironment regulation therapy. oxidase-like activity Au NPs inhibited glycolytic metabolism cells, reducing lactate efflux, reprogramming immunosuppression, ultimately increasing activation within Additionally, hypoxia environment could be relieved HRP enhance Au/PDA NPs-induced synergistic sonodynamic/photothermal (SDT/PTT), thereby promoting immunogenic death NALM 6 cells enhancing cell-mediated immune reprogramming. When this strategy utilized treat tumors, it not only completely eliminated also formed long-term memory effect inhibit metastasis recurrence. This work offers tumor.

Language: Английский

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Structure Engineered High Piezo‐Photoelectronic Performance for Boosted Sono‐Photodynamic Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)

Published: Nov. 7, 2023

Sono-photodynamic therapy is hindered by the limited tissue penetration depth of external light source and quick recombination electron-hole owing to random movement charge carriers. In this study, orthorhombic ZnSnO

Language: Английский

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