Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 675, P. 192 - 206
Published: July 3, 2024
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(11)
Published: Dec. 14, 2023
Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to trigger a robust antitumor immune response. Platinum-based chemotherapeutic agents can induce pyroptosis via caspase-3 activation. However, these also enhance cyclooxygenase-2 (COX-2) expression in tumor tissues, leading drug resistance and evasion pancreatic cancer significantly limiting the effectiveness chemotherapy-induced pyroptosis. Here, amphiphilic polymer (denoted as PHDT-Pt-In) containing both indomethacin (In, COX-2 inhibitor) platinum(IV) prodrug (Pt(IV)) is developed, which responsive glutathione (GSH). This self-assemble into nanoparticles Pt-In NP) that disintegrate cells due GSH responsiveness, releasing In inhibit expression, hence overcoming chemoresistance amplifying cisplatin-induced mouse model, NP growth elicit innate adaptive responses. Moreover, when combined with anti-programmed death ligand (α-PD-L1) treatment, demonstrate ability completely suppress metastatic tumors, transforming "cold tumors" "hot tumors". Overall, sustained release Pt(IV) from amplifies platinum-drug-induced long-term responses, presenting generalizable strategy for cancer.
Language: Английский
Citations
62
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: July 12, 2023
Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.
Language: Английский
Citations
56
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)
Published: Sept. 25, 2023
Unsatisfied tumor accumulation of chemotherapeutic drugs and a complicated immunosuppressive microenvironment diminish the immune response rate therapeutic effect. Surface modification these with target ligands can promote their cellular internalization, but modified may be subjected to unexpected recognition clearance. Herein, phenylboronic acid (PBA) group-shieldable dendritic nanomedicine that integrates an immunogenic cell death (ICD)-inducing agent (epirubicin, Epi) indoleamine 2,3-dioxgenase 1 (IDO1) inhibitor (NLG919) is reported for chemo-immunotherapy. This NLG919-loaded Epi-conjugated PEGylated dendrimers bridged boronate bonds (NLG919@Epi-DBP) maintains stable nanostructure during circulation. Under moderate acidic condition, PBA group exposes sialic residue on membrane enhance internalization penetration NLG919@Epi-DBP. At pH 5.0, NLG919@Epi-DBP rapidly disassembles release incorporated Epi NLG919. triggers robust ICD cells evokes strong response. In addition, inhibition IDO1 activity downregulates metabolism L-tryptophan kynurenine, leading reduction in recruitment modulation microenvironment. Collectively, this promising strategy has been demonstrated evoke as well remodel enhanced chemo-immunotherapeutic
Language: Английский
Citations
49
Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 445 - 472
Published: Oct. 26, 2023
Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.
Language: Английский
Citations
45
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692
Published: Jan. 1, 2024
This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.
Language: Английский
Citations
43
Science Advances, Journal Year: 2024, Volume and Issue: 10(19)
Published: May 8, 2024
Lactic acid (LA) accumulation in the tumor microenvironment poses notable challenges to effective immunotherapy. Here, an intelligent treatment microrobot based on unique physiological structure and metabolic characteristics of
Language: Английский
Citations
40
MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)
Published: March 1, 2024
Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding
Language: Английский
Citations
32
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)
Published: March 22, 2024
Abstract Nerve injury can lead to defects in related motor functions. It is critical achieve long‐term and convenient real‐time evaluation of function recovery status during nerve repair. In this study, an implantable PLLA/BTO piezoelectric sensor (PBPS) with good biodegradability biocompatibility for real time the after developed. PLLA fibers doped BTO are employed as material PBPS, which convert biomechanical signals generated by motion into electrical signals. PBPS be implant simultaneously commonly used tissue scaffolds treatment rats sciatic injury. The linearity pressure output voltage ≈0.9445. For effectiveness, process progresses, exhibited consistency EMG signals, indicating effectively function. Moreover, integration wireless module break limitations space sensing realize rat. based on may bring new ideas development bioelectronics.
Language: Английский
Citations
29
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(28)
Published: March 15, 2024
Abstract Bacterial infections pose a major concern for the medical community, especially regarding wound healing. Traditional passive antibiotic therapies can be cytotoxic and lead to bacterial resistance, posing continuing challenge treat. Based on precision therapy, novel targeted‐delivery nanosystem is developed efficiently eliminate bacteria promote bacteria‐infected Macrophage membranes pre‐activated by Staphylococcus aureus (MM Sa ) are prepared. In doing so, Toll‐like receptors (TLRs), typical pathogen‐associated molecular pattern (PAMP), significantly higher than normal macrophage 0 ). Subsequently, MM coated onto ultrasound‐triggered piezocatalytic nano‐barium titanate (BaTiO 3 , BTO) surfaces, these two components assembled form targeting delivery nanosystem, namely BTO@MM . The in vitro vivo results demonstrate that biocompatible target infected areas rapidly generate reactive oxygen species (ROS) kill under ultrasound (US) irradiation, as well accelerate Furthermore, prokaryotic RNA‐seq transcriptomics reveals changes membrane function substance, energy metabolism responsible targeted antibacterial ability of with US. Compared widely reported unselective agents, this has potential precise infection treatment using functions.
Language: Английский
Citations
26
ACS Nano, Journal Year: 2024, Volume and Issue: 18(8), P. 6314 - 6332
Published: Feb. 12, 2024
Immune checkpoint blockade (ICB) therapy still suffers from insufficient immune response and adverse effect of ICB antibodies. Chemodynamic (CDT) has been demonstrated to be an effective way synergize with therapy. However, a low generation rate reactive oxygen species poor tumor penetration CDT platforms decline the effects. Herein, charge-reversal nanohybrid Met@BF containing both Fe3O4 BaTiO3 nanoparticles in core Metformin (Met) on surface was fabricated for microenvironment (TME)- ultrasound (US)-activated piezocatalysis-chemodynamic immunotherapy cancer. Interestingly, had negative charge blood circulation, which rapidly changed into positive when exposed acidic TME attributed quaternization tertiary amine Met, facilitating deep penetration. Subsequently, US irradiation, produced H2O2 based piezocatalysis BaTiO3, greatly enhanced Fenton reaction Fe3O4, thus boosting robust antitumor response. Furthermore, PD-L1 expression inhibited by local released Met further augment effect, achieving inhibitions primary metastatic tumors. Such combination piezocatalysis-enhanced chemodynamic Met-mediated downregulation provides promising strategy cancer immunotherapy.
Language: Английский
Citations
23