International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7099 - 7121
Published: July 1, 2024
Abstract:
Introduction
of
exogenous
genes
into
target
cells
to
overcome
various
tumor
diseases
caused
by
genetic
defects
or
abnormalities
and
gene
therapy,
a
new
treatment
method,
provides
promising
strategy
for
treatment.
Over
the
past
decade,
therapy
has
made
exciting
progress;
however,
it
still
faces
challenge
low
nucleic
acid
delivery
release
efficiencies.
The
emergence
nonviral
vectors,
primarily
nanodelivery
systems
(NDRS),
resulted
in
historic
breakthrough
application
therapy.
NDRS,
especially
stimulus-responsive
NDRS
that
can
respond
timely
manner
changes
internal
external
microenvironment
(eg,
pH,
high
concentration
glutathione/reactive
oxygen
species,
overexpressed
enzymes,
temperature,
light,
ultrasound,
magnetic
field),
shown
excellent
loading
advantages
precision
efficiency
been
widely
applied.
only
disadvantage
is
poor
transfection
limits
in-depth
clinical
practice,
owing
presence
biological
barriers
body.
Therefore,
this
review
first
introduces
development
history
current
obstacles
faced
delivery,
strategies
these
obstacles,
conventional
then
focuses
on
latest
research
progress
improving
efficiency.
Finally,
future
challenges
prospects
may
face
transformation
are
discussed
provide
references
enhancing
Keywords:
treatment,
efficiency,
microenvironment,
physiological
barrier,
efficacy
improvement
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(11)
Published: Dec. 14, 2023
Pyroptosis,
an
emerging
mechanism
of
programmed
cell
death,
holds
great
potential
to
trigger
a
robust
antitumor
immune
response.
Platinum-based
chemotherapeutic
agents
can
induce
pyroptosis
via
caspase-3
activation.
However,
these
also
enhance
cyclooxygenase-2
(COX-2)
expression
in
tumor
tissues,
leading
drug
resistance
and
evasion
pancreatic
cancer
significantly
limiting
the
effectiveness
chemotherapy-induced
pyroptosis.
Here,
amphiphilic
polymer
(denoted
as
PHDT-Pt-In)
containing
both
indomethacin
(In,
COX-2
inhibitor)
platinum(IV)
prodrug
(Pt(IV))
is
developed,
which
responsive
glutathione
(GSH).
This
self-assemble
into
nanoparticles
Pt-In
NP)
that
disintegrate
cells
due
GSH
responsiveness,
releasing
In
inhibit
expression,
hence
overcoming
chemoresistance
amplifying
cisplatin-induced
mouse
model,
NP
growth
elicit
innate
adaptive
responses.
Moreover,
when
combined
with
anti-programmed
death
ligand
(α-PD-L1)
treatment,
demonstrate
ability
completely
suppress
metastatic
tumors,
transforming
"cold
tumors"
"hot
tumors".
Overall,
sustained
release
Pt(IV)
from
amplifies
platinum-drug-induced
long-term
responses,
presenting
generalizable
strategy
for
cancer.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 12, 2023
Abstract
Natural
living
materials
serving
as
biotherapeutics
exhibit
great
potential
for
treating
various
diseases
owing
to
their
immunoactivity,
tissue
targeting,
and
other
biological
activities.
In
this
review,
the
recent
developments
in
engineered
materials,
including
mammalian
cells,
bacteria,
viruses,
fungi,
microalgae,
plants,
active
derivatives
that
are
used
summarized.
Further,
future
perspectives
challenges
of
such
material‐based
discussed
provide
considerations
advances
biomedical
applications.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(2)
Published: Sept. 25, 2023
Unsatisfied
tumor
accumulation
of
chemotherapeutic
drugs
and
a
complicated
immunosuppressive
microenvironment
diminish
the
immune
response
rate
therapeutic
effect.
Surface
modification
these
with
target
ligands
can
promote
their
cellular
internalization,
but
modified
may
be
subjected
to
unexpected
recognition
clearance.
Herein,
phenylboronic
acid
(PBA)
group-shieldable
dendritic
nanomedicine
that
integrates
an
immunogenic
cell
death
(ICD)-inducing
agent
(epirubicin,
Epi)
indoleamine
2,3-dioxgenase
1
(IDO1)
inhibitor
(NLG919)
is
reported
for
chemo-immunotherapy.
This
NLG919-loaded
Epi-conjugated
PEGylated
dendrimers
bridged
boronate
bonds
(NLG919@Epi-DBP)
maintains
stable
nanostructure
during
circulation.
Under
moderate
acidic
condition,
PBA
group
exposes
sialic
residue
on
membrane
enhance
internalization
penetration
NLG919@Epi-DBP.
At
pH
5.0,
NLG919@Epi-DBP
rapidly
disassembles
release
incorporated
Epi
NLG919.
triggers
robust
ICD
cells
evokes
strong
response.
In
addition,
inhibition
IDO1
activity
downregulates
metabolism
L-tryptophan
kynurenine,
leading
reduction
in
recruitment
modulation
microenvironment.
Collectively,
this
promising
strategy
has
been
demonstrated
evoke
as
well
remodel
enhanced
chemo-immunotherapeutic
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(5), P. 2643 - 2692
Published: Jan. 1, 2024
This
review
discusses
the
structures
and
engineering
strategies
of
nanocatalysts,
highlighting
their
underlying
mechanisms
applications
in
cancer
immunotherapy.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(19)
Published: May 8, 2024
Lactic
acid
(LA)
accumulation
in
the
tumor
microenvironment
poses
notable
challenges
to
effective
immunotherapy.
Here,
an
intelligent
treatment
microrobot
based
on
unique
physiological
structure
and
metabolic
characteristics
of
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(28)
Published: March 15, 2024
Abstract
Bacterial
infections
pose
a
major
concern
for
the
medical
community,
especially
regarding
wound
healing.
Traditional
passive
antibiotic
therapies
can
be
cytotoxic
and
lead
to
bacterial
resistance,
posing
continuing
challenge
treat.
Based
on
precision
therapy,
novel
targeted‐delivery
nanosystem
is
developed
efficiently
eliminate
bacteria
promote
bacteria‐infected
Macrophage
membranes
pre‐activated
by
Staphylococcus
aureus
(MM
Sa
)
are
prepared.
In
doing
so,
Toll‐like
receptors
(TLRs),
typical
pathogen‐associated
molecular
pattern
(PAMP),
significantly
higher
than
normal
macrophage
0
).
Subsequently,
MM
coated
onto
ultrasound‐triggered
piezocatalytic
nano‐barium
titanate
(BaTiO
3
,
BTO)
surfaces,
these
two
components
assembled
form
targeting
delivery
nanosystem,
namely
BTO@MM
.
The
in
vitro
vivo
results
demonstrate
that
biocompatible
target
infected
areas
rapidly
generate
reactive
oxygen
species
(ROS)
kill
under
ultrasound
(US)
irradiation,
as
well
accelerate
Furthermore,
prokaryotic
RNA‐seq
transcriptomics
reveals
changes
membrane
function
substance,
energy
metabolism
responsible
targeted
antibacterial
ability
of
with
US.
Compared
widely
reported
unselective
agents,
this
has
potential
precise
infection
treatment
using
functions.
MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: March 1, 2024
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: March 22, 2024
Abstract
Nerve
injury
can
lead
to
defects
in
related
motor
functions.
It
is
critical
achieve
long‐term
and
convenient
real‐time
evaluation
of
function
recovery
status
during
nerve
repair.
In
this
study,
an
implantable
PLLA/BTO
piezoelectric
sensor
(PBPS)
with
good
biodegradability
biocompatibility
for
real
time
the
after
developed.
PLLA
fibers
doped
BTO
are
employed
as
material
PBPS,
which
convert
biomechanical
signals
generated
by
motion
into
electrical
signals.
PBPS
be
implant
simultaneously
commonly
used
tissue
scaffolds
treatment
rats
sciatic
injury.
The
linearity
pressure
output
voltage
≈0.9445.
For
effectiveness,
process
progresses,
exhibited
consistency
EMG
signals,
indicating
effectively
function.
Moreover,
integration
wireless
module
break
limitations
space
sensing
realize
rat.
based
on
may
bring
new
ideas
development
bioelectronics.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(8), P. 6314 - 6332
Published: Feb. 12, 2024
Immune
checkpoint
blockade
(ICB)
therapy
still
suffers
from
insufficient
immune
response
and
adverse
effect
of
ICB
antibodies.
Chemodynamic
(CDT)
has
been
demonstrated
to
be
an
effective
way
synergize
with
therapy.
However,
a
low
generation
rate
reactive
oxygen
species
poor
tumor
penetration
CDT
platforms
decline
the
effects.
Herein,
charge-reversal
nanohybrid
Met@BF
containing
both
Fe3O4
BaTiO3
nanoparticles
in
core
Metformin
(Met)
on
surface
was
fabricated
for
microenvironment
(TME)-
ultrasound
(US)-activated
piezocatalysis-chemodynamic
immunotherapy
cancer.
Interestingly,
had
negative
charge
blood
circulation,
which
rapidly
changed
into
positive
when
exposed
acidic
TME
attributed
quaternization
tertiary
amine
Met,
facilitating
deep
penetration.
Subsequently,
US
irradiation,
produced
H2O2
based
piezocatalysis
BaTiO3,
greatly
enhanced
Fenton
reaction
Fe3O4,
thus
boosting
robust
antitumor
response.
Furthermore,
PD-L1
expression
inhibited
by
local
released
Met
further
augment
effect,
achieving
inhibitions
primary
metastatic
tumors.
Such
combination
piezocatalysis-enhanced
chemodynamic
Met-mediated
downregulation
provides
promising
strategy
cancer
immunotherapy.
