Biomimetic Nanozyme-Decorated Hydrogels with H₂O₂-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16854 - 16869

Published: Aug. 25, 2023

Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels are promising systems for DFU-based wound management, their effectiveness is often hindered by the immune response and hostile microenvironment associated with uncontrollable accumulation of reactive oxygen species hypoxia. Here, we develop therapeutic dressing using biomimetic hydrogel system decoration catalase-mimic nanozyme, namely, MnCoO@PDA/CPH. The can be designed match mechanical electrical cues skins simultaneously H2O2-activated oxygenation ability. As proof concept, rat models created validate efficacy MnCoO@PDA/CPH in vivo. results indicate that developed promote DFU healing improve quality healed as featured alleviated proinflammatory, increased re-epithelialization, highly ordered collagen deposition, functional blood vessel growth.

Language: Английский

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Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

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Biodegradable Ferric Phosphate Nanocarriers with Tumor‐Specific Activation and Glutathione Depletion for Tumor Self‐Enhanced Ferroptosis and Chemotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 31, 2024

Abstract Ferroptosis is a regulatory cell death that dependent on iron‐mediated lipid peroxidation and membrane damage. The use of iron‐based nanocarriers to activate ferroptosis great significance in oncotherapy. However, the limited endogenous hydrogen peroxide (H 2 O ) high expression glutathione (GSH) tumor cells restrict efficiency inducing ferroptosis. Herein, ferric phosphate nanotherapeutic system (denoted as FeP@HCPT‐HA) reported with H ‐supply GSH‐elimination properties for self‐enhanced chemotherapy. FeP@HCPT‐HA obtained by coprecipitation method situ loading 10‐hydroxycamptothecin (HCPT), followed modification hyaluronic acid (HA). actively targets CD44‐overexpressed degrades acidic microenvironment release HCPT, Fe 2+ 3+ . As chemotherapy drug, HCPT not only induces apoptosis but also supplies ‐mediated Fenton reaction enhance released depletes GSH redox between GSH, which down‐regulates peroxidase 4 (GPX4) enhances peroxidation, resulting enhanced integration targeting tumor‐specific activation, well GSH‐elimination, endow effective growth inhibition

Language: Английский

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Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

RSC Advances, Journal Year: 2024, Volume and Issue: 14(15), P. 10608 - 10637

Published: Jan. 1, 2024

This review summarized the function of cancer cell membranes and comprehensively discussed preparation membrane-coated nanoparticles (CCM-NPs) their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).

Language: Английский

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Metal–organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 28, 2025

Cancer treatment is currently one of the most critical healthcare issues globally. A well-designed drug delivery system can precisely target tumor tissues, improve efficacy, and reduce damage to normal tissues. Stimuli-responsive systems (SRDDSs) have shown promising application prospects. Intelligent nano responsive endogenous stimuli such as weak acidity, complex redox characteristics, hypoxia, active energy metabolism, well exogenous like high temperature, light, pressure, magnetic fields are increasingly being applied in chemotherapy, radiotherapy, photothermal therapy, photodynamic various other anticancer approaches. Metal–organic frameworks (MOFs) become candidate materials for constructing SRDDSs due their large surface area, tunable porosity structure, ease synthesis modification, good biocompatibility. This paper reviews MOF-based modes cancer therapy. It summarizes key aspects, including classification, synthesis, modifications, loading modes, stimuli-responsive mechanisms, roles different modalities. Furthermore, we address current challenges summarize potential applications artificial intelligence MOF synthesis. Finally, propose strategies enhance efficacy safety SRDDSs, ultimately aiming at facilitating clinical translation.

Language: Английский

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Tunable metal–organic frameworks assist in catalyzing DNAzymes with amplification platforms for biomedical applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(21), P. 7549 - 7578

Published: Jan. 1, 2023

Various binding modes of tunable metal organic frameworks (MOFs) and functional DNAzymes (Dzs) synergistically catalyze the emergence abundant nanoplatforms.

Language: Английский

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Target‐Specific Bioorthogonal Reactions for Precise Biomedical Applications

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(49)

Published: Aug. 7, 2023

Abstract Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the native environment. Recently, bioorthogonal reactions have attracted considerable attention medical field treating diseases, since this approach may lead to improved drug efficacy and reduced side effects via situ synthesis. For precise biomedical applications, it prerequisite that should occur right locations on appropriate therapeutic targets. In minireview, we highlight design development of targeted treatment. First, compile recent strategies achieving target‐specific reactions. Further, emphasize their application treatment different Finally, perspective provided challenges future directions emerging safe, efficient, translatable disease

Language: Английский

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MOF-based micro/nanomotors (MOFtors): Recent progress and challenges

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 495, P. 215372 - 215372

Published: Aug. 10, 2023

Language: Английский

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Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity

Advanced Science, Journal Year: 2023, Volume and Issue: 11(3)

Published: Nov. 20, 2023

Abstract Cancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host antitumor immune response. However, direct use of inducers or regulators may bring about severe side effects that also be rapidly excreted degraded low efficacy. Nanomaterials able carry them for long circulation time, high tumor accumulation controlled release achieve satisfactory effect. Nowadays, large number studies focused on nanomedicines‐based strategies through modulating modalities potentiate immunity. Herein, types their function first summarized, state‐of‐the‐art research progresses in nanomedicines mediated pathways (e.g., cuproptosis) response provocation highlighted. Subsequently, the conclusion outlook potential focus discussed.

Language: Английский

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