Super‐Structured Wet‐Adhesive Hydrogel with Ultralow Swelling, Ultrahigh Burst Pressure Tolerance, and Anti‐Postoperative Adhesion Properties for Tissue Adhesion

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(11)

Published: Nov. 28, 2023

Abstract Wet‐adhesive hydrogels have been developed as an attractive strategy for tissue repair. However, achieving simultaneously low swelling and high burst pressure tolerance of wet‐adhesive is crucial in vivo application which remains challenges. Herein, a novel super‐structured porous hydrogel (denoted PVA/PAAc‐N + ) designed via facile moisture‐induced phase separation‐solvent exchange process obtaining polyvinyl alcohol (PVA) dissipative layer situ photocuring technology entangling quaternary ammonium‐functionalized poly(acrylic acid)‐based (PAAc‐N with the surface PVA layer. Benefitting from ionic crosslinking between ammonium ions carboxylate PAAc‐N well crystallinity induced by abundant hydrogen bonds layer, has unique ultralow property (0.29) without sacrificing adhesion strength (63.1 kPa). The structure facilitates mechanical interlock at interface tough leading to ultrahigh up 493 mm Hg effective repair porcine heart rupture; can prevent postoperative adhesion. By integrating swelling, tolerance, anti‐postoperative properties, shows appealing prospect

Language: Английский

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A Robust and Adhesive Hydrogel Enables Interfacial Coupling for Continuous Temperature Monitoring

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(33)

Published: April 25, 2023

Abstract Continuous temperature monitoring by flexible hydrogel‐based electronics achieves rapid advances, overcoming the drawbacks of rigid and unportable thermocouples. However, an open question is whether how thermosensitive hydrogel designing can prevent mechanical mismatching between devices skin‐tissues reduces interfacial failure. Herein, a versatile thermistor epidermal sensor (HTES) paradigm engineered consisting self‐adhesive function layer (PEST) in tandem with surface spraying Ag interdigital electrode. Leveraging advantage catechol chemistry inspired tannic acid‐coated cellulose nanocrystals, resultant PEST adhesion‐cohesion equilibrium along superior thermosensitivity. The assembled HTES thereby yields unprecedented features thermosensitivity (TCR = 1.43% °C −1 ), exceptional integrity (hammering 200 cycles, current variation <9%), impressive compatibility (adhesion strength, 25 kPa), environmental stability (thermosensation retention 98% over 5 days). By in‐situ microstructure observation, unique geometrical synchronization arbitrary curvilinear surfaces (e.g., sphere, cone, saddle) stemming from elastic dissipation discrete rupture adhesive fibrillar bridges validated, affording competitive advantages than that state‐of‐the‐art for alleviating deterioration, which dramatically inspires advanced design strategies paves way commercialization attachable electronics.

Language: Английский

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Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(32)

Published: June 8, 2023

Abstract The desirable implantable neural interfaces can accurately record bioelectrical signals from neurons and regulate activities with high spatial/time resolution, facilitating the understanding of neuronal functions dynamics. However, electrochemical performance (impedance, charge storage/injection capacity) is limited miniaturization integration electrodes. “crosstalk” caused by uneven distribution elctric field leads to lower electrical stimulation/recording efficiency. mismatch between stiff electrodes soft tissues exacerbates inflammatory responses, thus weakening transmission signals. Though remarkable breakthroughs have been made through incorporation optimizing electrode design functionalized nanomaterials, chronic stability, long‐term activity in vivo still need further development. In this review, interface challenges mainly on electrochemistry biology are discussed, followed summarizing typical optimization technologies exploring recent advances application based traditional metallic materials, emerging 2D conducting polymer hydrogels, etc., for enhancing interfaces. strategies improving durability including enhanced adhesion minimized response, also summarized. promising directions finally presented provide enlightenment high‐performance future, which will promote profound progress neuroscience research.

Language: Английский

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Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 319, P. 102982 - 102982

Published: Aug. 13, 2023

Language: Английский

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Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150756 - 150756

Published: March 26, 2024

Language: Английский

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Nature-inspired adhesive systems

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(16), P. 8240 - 8305

Published: Jan. 1, 2024

Many organisms in nature thrive intricate habitats through their unique bio-adhesive surfaces, facilitating tasks such as capturing prey and reproduction. It's important to note that the remarkable adhesion properties found these natural biological surfaces primarily arise from distinct micro- nanostructures and/or chemical compositions. To create artificial with superior capabilities, researchers delve deeper into underlying mechanisms of captivating phenomena draw inspiration. This article provides a systematic overview various different mechanisms, focusing on surface chemistry, offering design principles for counterparts. Here, basic interactions models are introduced first. will be followed by an exploration research advancements adhesive including both dry wet/underwater along relevant characterization techniques. Special attention is paid stimulus-responsive smart tunable properties. The goal spotlight recent advancements, identify common themes, explore fundamental distinctions pinpoint present challenges prospects this field.

Language: Английский

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Versatile Biomass‐Based Injectable Photothermal Hydrogel for Integrated Regenerative Wound Healing and Skin Bioelectronics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 11, 2024

Abstract The continuously growing utilization of wound healing materials and skin bioelectronics urges the development flexible hydrogels for personal therapy health management. Versatile conductive prepared from natural biomass are ideal candidates as one promising solutions chronic Here, study proposes a kind robust (strain: 1560.8%), adhesive, self‐healing, injectable, antibacterial (sterilization rate: 99%), near‐infrared (NIR) photothermal responsive, biocompatible, hydrogel (CPPFe@TA) composed carboxymethyl cellulose tannic acid/iron ion complex (TA@Fe 3+ ), featuring rapid self‐assembly tunable crosslinking time. TA@Fe facilitated self‐catalysis polymerization reaction, time could be controlled by adjusting Fe concentration. Under NIR irradiation, exhibited remarkable performance. In full‐thickness defect repair experiment on mice, dressing significantly enhanced healing. After 14 days, rate (95.49%) CPPFe@TA3 + treatment greatly exceeded that commercial dressings. Meanwhile, has good electrical conductivity thermo‐responsiveness, making them in physiological signal monitoring rehabilitation exercise This work therefore offers strategy developing versatile biomass‐based hydrogels, which is expected to applicable integrated regenerative bioelectronics.

Language: Английский

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Janus Hydrophobic Structural Gel with Asymmetric Adhesion in Air/Underwater for Reliable Mechanosensing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: March 29, 2024

Abstract Reliable interfacial bonding is an essential guarantee that flexible electronics can output realistic signals, especially for underwater scenes. However, conventional self‐adhesive materials usually suffer from adhesion failure, conflict between and cohesion, as well adverse effects of isotropous residue, greatly limiting their applications in electronics. Herein, a Janus hydrophobic structural gel (HSG) with asymmetric fabricated by “grafting one twig on another” approach (in situ constructing anti‐adhesive the top gel). The layer long C18 aliphatic chains achieves reliable (interfacial toughness exceeds 80 J m −2 ) assistance high mobility polymer chains, multiple interactions, effective removal liquid. anti‐adhesion containing poly(ionic liquid) more robust due to electrostatic ion‐dipole ensuring mechanical strength integral HSG. Such heterostructure avoids common nonessential facilitating operation. intrinsic hydrophobicity HSG also prevents water erosion, achieving sensing. As result, assembled sensor based stably monitor human motions wirelessly transmit information, exhibiting enormous potential wearable

Language: Английский

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Water: The soul of hydrogels

Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101378 - 101378

Published: Sept. 1, 2024

Language: Английский

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Hemostasis Strategies and Recent Advances in Hydrogels for Managing Uncontrolled Hemorrhage

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Hemorrhage continues to pose a significant challenge in various medical contexts, underscoring the need for advanced hemostatic materials. Hemostatic hydrogels have gained recognition as innovative tools addressing uncontrollable bleeding, attributed their distinctive features including biological compatibility, tunable mechanical properties, and exceptional performance. This review provides comprehensive overview of that offer rapid effective bleeding control. Particularly, this focuses on hydrogel design associated mechanisms. Additionally, recent advancements application these materials are discussed detail, especially clinical trials. Finally, challenges potential analyzed assessed. seeks emphasize role biomedical applications hemorrhage control provide perspectives innovation clinically applicable

Language: Английский

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