A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 25, 2024

Abstract Bacterial infection at wound sites can easily induce robust inflammation. M1 macrophages cause cascade inflammatory reactions to mediate a vicious inflammation cycle. Meanwhile, the hypoxia situation further aggravates destruction and contraction of blood vessels in microenvironment, therefore, hindering infected healing process. Here, thermosensitive hydrogel is reported solve above challenges by eliminating bacteria based on photothermal effect, regulating immune providing oxygen (O 2 ). In vitro vivo experiments confirmed that has great O ‐producing properties. Based excellent properties AIEgens, good bactericidal effect against S. aureus (100%) E. coli (98.85%). The RNA‐sequencing revealed Cur@AIE@MnO /gel interfere with metabolic process genetic material repair impact proliferation biofilm dispersal, thus achieving anti‐bacterial efficacy. Moreover, also up‐regulate anti‐inflammatory genes, down‐regulate pro‐inflammatory genes macrophages, facilitate promotion macrophage polarization from M2 relieve therapeutic show this accelerated wound‐healing Therefore, work may open new avenues for development novel dressings bacterial‐infected wounds.

Language: Английский

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Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14085 - 14122

Published: May 22, 2024

Infectious diseases pose a serious threat and substantial economic burden on global human public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless their antibiotic susceptibility. contrast conventional therapies, these approaches facilitate precise targeting pathogenic and/or infectious microenvironments, effectively minimizing toxicity mammalian cells surrounding healthy tissues. The highlighted include photodynamic therapy, photocatalytic photothermal endogenous pigments-based photobleaching polyphenols-based photo-oxidation therapy. comprehensive exploration aims offer updated information development effective, convenient, safe, alternative counter growing MDR future.

Language: Английский

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Bioinspired AIE Nanomedicine: A Burgeoning Technology for Fluorescence Bioimaging and Phototheranostics

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 14, 2024

Abstract Nanomedicine on the basis of aggregated‐induced emission (AIE) luminogens with exceptional potency is growing into a sparkling frontier in fluorescence imaging and phototheranostics. Of particular interest biomimetic AIE nanomedicine comprised by biocarrier, which represents win–win integration are recently developed at tremendous pace, mainly benefiting from intrinsic advantages including enhanced biocompatibility, prolonged circulation time, specific targeting ability, immune activation, supremely extraordinary phototheranostic outputs. In view inexhaustible vigorous vitality field, this review provides an integrated picture involving basic concepts, significant breakthroughs, recent trends. addition, based current achievements, some critical challenges perspectives also discussed.

Language: Английский

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Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 31, 2024

Abstract Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together non‐ideal solvents or within solid matrix. Since the concept of AIE was first introduced 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and life sciences. Of particular note growing interest application systems with near‐infrared (NIR) emissive feature field biomedicine, encompassing detection, imaging, therapeutic interventions. Notably, bibliometric analysis serves as valuable tool to provide researchers comprehensive understanding research achievements developmental trends fields, which crucial for academic research. Herein, we present general overview spanning two decades NIR‐AIE development. With assistance core scientific databases software tools, conducted systematic annual publications citations, most influential countries/regions, leading authors, journals, institutions, well hot topics related NIR forward‐looking predictions. Furthermore, properties biomedical also systematically reviewed.

Language: Английский

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Targeted antibacterial photodynamic therapy with aggregation‐induced emission photosensitizers

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(1)

Published: Jan. 1, 2024

Abstract With the increasing prevalence of infectious diseases caused by drug‐resistant bacteria, there is an urgent need to develop innovative therapies alternative antibiotics. Among these alternatives, aggregation‐induced emission (AIE) photosensitizers (PSs) stand out with their integrated imaging and therapeutic functionalities, allowing for early monitoring image‐guided ablation bacteria. AIE fluorescent probes unique optical properties excel in selective bacterial imaging. Furthermore, AIE‐enabled reactive oxygen species (ROS)‐mediated antibacterial photodynamic therapy can operate on multiple targets oxidize Also, as they are able specifically target PSs ameliorate limitations small‐scale action ROS. This review methodically discusses different strategies that be employed using targeting including sheltered The challenges future opportunities this emerging field also briefly discussed.

Language: Английский

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The One‐Stop Integrated Nanoagent Based on Photothermal Therapy for Deep Infection Healing and Inflammation Inhibition

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 20, 2023

Abstract Chronic wounds caused by bacterial infections are a major challenge in medical fields. The hypoxia condition extremely induces reactive oxygen species (ROS) generation and upregulates the expression of hypoxia‐inducible factor, both which can increase pro‐inflammatory M1 subtype macrophages production while reducing anti‐inflammatory M2 macrophages. Besides, bacteria‐formed biofilms hinder penetration therapeutic agents. Encouraged natural motors automatically executing tasks, hypothesized that supplying sufficient (O 2 ) would simultaneously drive agent movement, rescue hypoxic microenvironment, disrupt vicious cycle inflammation. Here, small organic molecule‐based nanoparticles (2TT‐mC6B@Cu 5.4 O NPs) possess high photothermal conversion efficiency enzymatic activities developed, including superoxide dismutase‐, catalase‐, glutathione peroxidase‐like activity. 2TT‐mC6B@Cu NPs exhibit superior ROS‐scavenging abilities synergistically relieve inflammation, alleviate conditions, promote their deep chronic wound tissues. Transcriptome analysis further demonstrates 2TT‐[email protected] inhibit biological inside bacteria. Furthermore, vivo experiments prove NPs‐based hyperthermia effectively eliminate bacteria to healing.

Language: Английский

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Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4485 - 4505

Published: Aug. 1, 2023

Abstract: Pluronic F127 hydrogel biomaterial has garnered considerable attention in wound healing and repair due to its remarkable properties including temperature sensitivity, injectability, biodegradability, maintain a moist environment. This comprehensive review provides an in-depth exploration of the recent advancements F127-derived hydrogels, such as F127-CHO, F127-NH 2 , F127-DA, focusing on their applications treatment various types wounds, ranging from burns acute wounds infected diabetic cutaneous tumor uterine scars. Furthermore, meticulously examines intricate interaction mechanisms employed by these hydrogels within microenvironment. By elucidating underlying mechanisms, discussing strengths weaknesses F127, analyzing current state development, expanding trend targeting mitochondria cells with nanomaterial. The enhances our understanding therapeutic effects aims foster development effective safe wound-healing modalities. valuable insights provided this have potential inspire novel ideas for clinical facilitate advancement innovative management approaches. Keywords:

Language: Английский

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Convergence of nanomedicine and neutrophils for drug delivery

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 150 - 166

Published: Jan. 27, 2024

Neutrophils have recently emerged as promising carriers for drug delivery due to their unique properties including rapid response toward inflammation, chemotaxis, and transmigration. When integrated with nanotechnology that has enormous advantages in improving treatment efficacy reducing side effects, neutrophil-based nano-drug systems expanded the repertoire of nanoparticles employed precise therapeutic interventions by either coating membranes, loading inside living cells, or engineering chimeric antigen receptor (CAR)-neutrophils. These neutrophil-inspired therapies shown superior biocompatibility, targeting ability, robustness. In this review, we summarized benefits combining neutrophils nanotechnologies, design principles underlying mechanisms, various applications disease treatments. The challenges prospects were also discussed.

Language: Английский

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Carbon Dots with Integrated Photothermal Antibacterial and Heat‐Enhanced Antioxidant Properties for Diabetic Wound Healing

Small, Journal Year: 2024, Volume and Issue: 20(45)

Published: July 25, 2024

Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.

Language: Английский

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Inspired by nature: Bioinspired and biomimetic photocatalysts for biomedical applications

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

The field of photocatalysis has witnessed a significant advancement in the development bioinspired and biomimetic photocatalysts for various biomedical applications, including drug delivery, tissue engineering, cancer therapy, bioimaging. Nature evolved efficient light-harvesting systems energy conversion mechanisms, which serve as benchmark researchers. However, reproducing such complexity harnessing it applications is daunting task. It requires comprehensive understanding underlying biological processes ability to replicate them synthetically. By utilizing light energy, these can trigger specific chemical reactions, leading targeted release, enhanced regeneration, precise imaging structures. In this context, addressing stability, long-term performance, scalability, cost-effectiveness materials crucial their widespread implementation applications. While challenges stability persist, advantages delivery personalized medicine make fascinating area research. purpose review provide analysis evaluation existing research, highlighting advancements, current challenges, advantages, limitations, future prospects biomedicine.

Language: Английский

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