Expanding Our Horizons: AIE Materials in Bacterial Research

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.

Language: Английский

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Rational design of photofunctional dyes BODIPYs/aza-BODIPYs and applications for photocatalysis, photoelectric conversion and thermochromic materials

Resources Chemicals and Materials, Journal Year: 2024, Volume and Issue: 3(2), P. 103 - 122

Published: Jan. 15, 2024

4,4-Difluoro-4-bora-3a,4a-diaza-sindacene (BODIPY) is a sort of photofunctional dye which possesses advantages including strong light-capturing property, high photon-resistance, etc. Meso-N substituted aza-BODIPY crucial derivative BODIPY scaffold that has the favorable optical properties and significant spectral redshift. The photophysical can be tuned by molecular design, attenuation path excited state energy release absorbed light well controlled via structural modifications, enabling tailored application. It been extensively employed in life medicine fields fluorescence imaging diagnosis, photodynamic therapy photosensitizer photothermal reagent so forth. Extensive research review have performed these areas. However, BODIPYs/aza-BODIPYs role energy, catalysis, optoelectronics, photo-responsive materials other fields. Nevertheless, there are relatively few studies reviews on modification application based BODIPY/aza-BODIPY scaffold. Herein, this we summarized aforementioned fields, with regulation as foundation utilization above objective, intention providing inspiration for exploration innovative field resource conversion functional materials.

Language: Английский

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Anticoagulation colloidal microrobots based on heparin-mimicking polymers

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137345 - 137345

Published: March 1, 2025

Language: Английский

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Neutrophil‐Mimetic, ROS Responsive, and Oxygen Generating Nanovesicles for Targeted Interventions of Refractory Rheumatoid Arthritis

Small, Journal Year: 2023, Volume and Issue: 20(20)

Published: Dec. 12, 2023

Abstract Rheumatoid arthritis (RA) is the most prevalent inflammatory joint disease worldwide, leading to irreversible disability and even mortality. Unfortunately, current treatment regimens fail cure RA due low therapeutic responses off‐target side effects. Herein, a neutrophil membrane‐cloaked, natural anti‐arthritic agent leonurine (Leo), catalase (CAT) co‐loaded nanoliposomal system (Leo@CAT@NM‐Lipo) constructed remodel hostile microenvironment for remission. Due inflammation tropism inherited from neutrophils, Leo@CAT@NM‐Lipo can target accumulate in inflamed cavity where high‐level ROS be catalyzed into oxygen by CAT simultaneously accelerate drug release alleviate hypoxia at lesion site. Besides, membrane camouflaging also enhances anti‐inflammatory potentials of robustly absorbing pro‐arthritogenic cytokines chemokines. Consequently, successfully alleviated paw swelling, reduced score, mitigated bone cartilage damage, reversed multiple organ dysfunctions adjuvant‐induced rats (AIA) synergistic effects macrophage polarization, resolution, scavenging, relief. Furthermore, manifested excellent biocompatibility both cellular animal levels. Taken together, study provided neutrophil‐mimetic responsive nanoplatform targeted therapy represented promising paradigm variety inflammation‐dominated diseases.

Language: Английский

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Bio-Hybrid Magnetic Robots: From Bioengineering to Targeted Therapy

Bioengineering, Journal Year: 2024, Volume and Issue: 11(4), P. 311 - 311

Published: March 26, 2024

Magnetic robots possess an innate ability to navigate through hard-to-reach cavities in the human body, making them promising tools for diagnosing and treating diseases minimally invasively. Despite significant advances, development of with desirable locomotion full biocompatibility under harsh physiological conditions remains challenging, which put forward new requirements magnetic robots’ design material synthesis. Compared that are synthesized inorganic materials, natural organisms like cells, bacteria or other microalgae exhibit ideal properties vivo applications, such as biocompatibility, deformability, auto-fluorescence, self-propulsion, well easy functional therapeutics engineering. In process, these can provide autonomous propulsion biological fluids external fields, while retaining their functionalities integrating artificial robots, thus aiding targeted therapeutic delivery. This kind robotics is named bio-hybrid robotics, this mini-review, recent progress including design, engineering potential delivery will be discussed. Additionally, historical context prominent examples introduced, complexities, pitfalls, opportunities associated

Language: Английский

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Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 15, 2024

Exploring effective antibacterial approaches for targeted treatment of pathogenic bacterial infections with reduced drug resistance is great significance. Combinational modality that leverages different therapeutic components can improve the overall effectiveness and minimize adverse effects, thus displaying considerable potential against infections. Herein, red blood cell membrane fuses macrophage to develop hybrid shell, which further camouflages around drug-loaded liposome fabricate biomimetic (AB@LRM) precise therapy. Specifically, photoactive agent black phosphorus quantum dots (BPQDs) classical antibiotics amikacin (AM) are loaded in AB@LRM accurately target inflammatory sites through guidance long residence capability membrane, eventually exerting efficacious activities. Besides, due excellent photothermal photodynamic properties, BPQDs act as an efficient when exposed near-infrared laser irradiation, dramatically increasing sensitivity bacteria antibiotics. Consequently, synergistic sterilizing effect produced by restricts resistance. Upon shows superior anti-inflammatory properties models P. aeruginosa-infected pneumonia wounds. Hence, this light-activatable nanoplatform good biocompatibility presents advance clinical development

Language: Английский

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NIR‐II AIEgens for Infectious Diseases Phototheranostics

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(51)

Published: Aug. 26, 2024

Abstract Pathogenic infectious diseases have persistently posed significant threats to public health. Phototheranostics, which combines the functions of diagnostic imaging and therapy, presents an extremely promising solution block spread pathogens as well outbreak epidemics owing its merits a wide‐spectrum activity, high controllability, non‐invasiveness, difficult acquire resistance. Among multifarious phototheranostic agents, second near‐infrared (NIR‐II, 1000–1700 nm) aggregation‐induced emission luminogens (AIEgens) are notable by virtue their deep penetration depth, excellent biocompatibility, balanced radiative nonradiative decay aggregation‐enhanced theranostic performance, making them ideal option for combating pathogens. This minireview provides systematical summary latest advancements in NIR‐II AIEgens with emphasis on molecular design nanoplatform formulation fulfill high‐efficiency treating bacterial viral pathogens, classified disease models. Then, current challenges, potential opportunities, future research directions presented facilitate further progress this emerging field.

Language: Английский

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Chitosan modified magnetic nanocomposite for biofilm destruction and precise photothermal/photodynamic therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129402 - 129402

Published: Jan. 13, 2024

Language: Английский

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Altering central atoms and bromination sites of phosphorescence units to control ultralong organic room temperature phosphorescence

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 227, P. 112186 - 112186

Published: May 1, 2024

Language: Английский

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Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(1), P. 13 - 38

Published: Nov. 29, 2023

Inflammatory bowel disease (IBD) is a chronic and idiopathic condition that results in inflammation of the gastrointestinal tract, leading to conditions such as ulcerative colitis Crohn's disease.

Language: Английский

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