Structurally Oriented Carbon Dots as ROS Nanomodulators for Dynamic Chronic Inflammation and Infection Elimination

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 22055 - 22070

Published: Aug. 8, 2024

The selective elimination of cytotoxic ROS while retaining essential ones is pivotal in the management chronic inflammation. Co-occurring bacterial infection further complicates conditions, necessitating precision and an efficacious treatment strategy. Herein, dynamic nanomodulators are rationally constructed through regulating surface states herbal carbon dots (CDs) for on-demand inflammation or elimination. phenolic OH containing CDs derived from honeysuckle (HOCD) dandelion (DACD) demonstrated appropriate redox potentials, ensuring their ability to scavenge such as ·OH ONOO–, invalidity toward O2·–, H2O2, NO. This enables efficient without affecting signal pathways. C–N/C═N taxus leaves (TACD) DACD renders them with suitable band structures, facilitating absorption red region generation O2·– upon light irradiation sterilization. Specifically, facilely prepared demonstrates fascinating modulating ability, making it highly addressing concurrent infection, diabetic wound infection. regulation strategy facilitates realization precise minimal side effects, holding immense potential clinical practice.

Language: Английский

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Two‐Tailed Dynamic Covalent Amphiphile Combats Bacterial Biofilms

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: May 19, 2023

Drug combination provides an efficient pathway to combat drug resistance in bacteria and bacterial biofilms. However, the facile methodology construct combinations their applications nanocomposites is still lacking. Here two-tailed antimicrobial amphiphiles (T2 A2 ) composed of nitric oxide (NO)-donor (diethylenetriamine NONOate, DN) various natural aldehydes are reported. T2 self-assemble into nanoparticles due amphiphilic nature, with remarkably low critical aggregation concentration. The representative cinnamaldehyde (Cin)-derived (Cin-T2 assemblies demonstrate excellent bactericidal efficacy, notably higher than free Cin DN. Cin-T2 kill multidrug-resistant staphylococci eradicate biofilms via multiple mechanisms, as proved by mechanism studies, molecular dynamics simulations, proteomics, metabolomics. Furthermore, rapidly alleviate inflammation subsequent murine infection models. Together, may provide efficient, non-antibiotic alternative combating ever-increasing threat drug-resistant

Language: Английский

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Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)

Published: July 20, 2023

Abstract The discovery of antibiotics has saved millions lives, but the emergence antibiotic‐resistant bacteria become another problem in modern medicine. To avoid or reduce overuse antibacterial treatments, stimuli‐responsive materials, pathogen‐targeting nanoparticles, immunogenic nano‐toxoids, and biomimetic materials are being developed to make sterilization better smarter than conventional therapies. common goal smart (SAMs) is increase antibiotic efficacy function via an mechanism different from that order biological properties while reducing risk drug resistance. research development SAMs increasingly interdisciplinary because new designs require knowledge fields input/collaboration scientists fields. A good understanding energy conversion physiological characteristics cells bacteria, bactericidal structures components nature expected promote SAMs. In this review, importance multidisciplinary insights for emphasized, latest advances categorized discussed according pertinent disciplines including science, physiology, biomimicry.

Language: Английский

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Tandem Guest‐Host‐Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(32)

Published: June 24, 2023

Abstract Staphylococcus aureus ( S. ) is able to hide within host cells escape immune clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design an adamantane (Ada)‐containing antibiotic‐peptide precursor Ada‐Gly‐Tyr‐Val‐Ala‐Asp‐Cys(StBu)‐Lys(Ciprofloxacin)‐CBT Cip‐CBT‐Ada ), we propose a strategy tandem guest‐host‐receptor recognitions precisely guide ciprofloxacin eliminate . Via guest‐host recognition, decorated with β‐cyclodextrin‐heptamannoside CD‐M derivative yield Cip‐CBT‐Ada/CD‐M , which target mannose receptor‐overexpressing macrophages via multivalent ligand‐receptor recognition. After uptake, undergoes caspase‐1 (an overexpressed enzyme during infection)‐initiated CBT‐Cys click reaction self‐assemble into nanoparticle Nano‐Cip In vitro in vivo experiments demonstrate that, compared or shows superior bacteria elimination inflammation alleviation efficiency ‐infected RAW264.7 mouse infection models, respectively. This work provides supramolecular platform antibiotics efficiently.

Language: Английский

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Microenvironment‐Adaptive Metallo‐Polymeric Nanodecoys via Subcomponent Coordination for Bacterial Biofilm Eradication and Immunomodulation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 27, 2024

Abstract Biofilm‐associated infections pose complex challenges that require addressing the multifaceted requirements of biofilm disruption, bacterial killing, and immunomodulation. In this study, microenvironment‐adaptive metallo‐polymeric nanodecoys (MPNs) are synthesized through one‐pot subcomponent coordination in aqueous solution, effectively eradicating biofilms modulating immune response. Within acidic microenvironment biofilms, positively charged MPNs demonstrated ability to interact with eliminate bacteria while facilitating a Fenton‐like reaction for efficient eradication biofilms. As local shifted from neutral basic state during subsequent tissue healing processes, adaptively harness multiple properties bind pathogen‐associated molecular patterns, scavenge reactive oxygen species, thereby response, alleviating inflammation, promoting healing. This study presents an strategy preparing enzyme‐mimicking materials closely resemble natural metalloenzymes, offer alternative current antibiotic treatments biofilm‐associated infections.

Language: Английский

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Strategies and materials for the prevention and treatment of biofilms

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100827 - 100827

Published: Oct. 2, 2023

Biofilms are aggregates of organized microbial growth that function as barriers and create a stable internal environment for cell survival. The bacteria in the biofilms exhibit characteristics quite different from planktonic bacteria, such strong resistance to antibiotics other bactericides, getting out host immunity, developing harsh environments, which all contribute persistent intractable treatment. Hence, there is an urgent need develop novel materials strategies combat biofilms. However, most reviews on anti-biofilms published recent years based specific fields or materials. Microorganisms ubiquitous, except context medical health issues; however, exert detrimental effects advancement progress various fields. Therefore, this review aims provide comprehensive summary effective methodologies applicable across industries. Firstly, process formation was introduced enhance our comprehension "enemy". Secondly, intervene important links were discussed, taking timely action during early weak stages Thirdly, treatment mature summarized deal with break through defense line. Finally, several substances antibacterial properties presented. concludes standpoint author about potential developments strategies. This may help researchers quickly understand research challenges field design more efficient methods

Language: Английский

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Biosensors with Boronic Acid-Based Materials as the Recognition Elements and Signal Labels

Biosensors, Journal Year: 2023, Volume and Issue: 13(8), P. 785 - 785

Published: Aug. 3, 2023

It is of great importance to have sensitive and accurate detection cis-diol-containing biologically related substances because their important functions in the research fields metabolomics, glycomics, proteomics. Boronic acids can specifically reversibly interact with 1,2- or 1,3-diols form five six cyclic esters. Based on this unique property, boronic acid-based materials been used as synthetic receptors for specific recognition species. This review critically summarizes recent advances elements signal labels biological species, including ribonucleic acids, glycans, glycoproteins, bacteria, exosomes, tumor cells. We also address challenges future perspectives developing versatile various promising applications.

Language: Английский

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Injective Programmable Proanthocyanidin‐Coordinated Zinc‐Based Composite Hydrogel for Infected Bone Repair

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(6)

Published: Oct. 27, 2023

Abstract Effectively integrating infection control and osteogenesis to promote infected bone repair is challenging. Herein, injective programmable proanthocyanidin (PC)‐coordinated zinc‐based composite hydrogels (ipPZCHs) are developed by compositing antimicrobial antioxidant PC‐coordinated zinc oxide (ZnO) microspheres with thioether‐grafted sodium alginate (TSA), followed calcium chloride (CaCl 2 ) crosslinking. Responsive the high endogenous reactive oxygen species (ROS) microenvironment in defects, hydrophilicity of TSA can be significantly improved, trigger disintegration ipPZCHs fast release ZnOs. This together easily dissociable PC‐Zn 2+ coordination induced (Zn with/without silver (Ag + ions from ZnOs (for Zn , > 100 times that pure ZnO) guarantees strong activity ipPZCHs. The exogenous ROS generated ZnO nanoparticles during process further speeds up ipPZCHs, augmenting efficacy. At same time, ROS‐responsive degradation/disintegration vacates space for ingrowth. concurrently released PC scavenges excess thus enhances immunomodulatory (in promoting anti‐inflammatory phenotype (M2) polarization macrophages) osteoinductive properties effectively promoted via aforementioned self‐adaptive processes.

Language: Английский

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Development and Analysis of Silver Nitroprusside Nanoparticle-Incorporated Sodium Alginate Films for Banana Browning Prevention

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(3), P. 292 - 292

Published: Jan. 31, 2024

Banana (Musa acuminate) has been popular among consumers worldwide due to its rich nutrients and minerals. However, bananas are highly susceptible the physical biological factors that lead postharvest loss during transportation storage. In this work, novel sodium alginate (SA) films incorporated with silver nitroprusside nanoparticles (AgNNPs) were prepared extend shelf life of through antibacterial antioxidant coating. The results exhibited AgNNPs cubical their size was <500 nm, metal composition being Ag Fe. Additionally, incorporation in SA film seen FE-SEM zeta analysis, an average about 365.6 nm. Furthermore, functional crystalline properties assessed FTIR XRD. Transmittance testing SA-AgNNPs confirmed they have good UV barrier properties. excellent high activity against foodborne pathogens including L. monocytogenes, S. enterica, E. coli at concentration 500 µg/mL. Moreover, storage bananas, nanocomposite coatings act as a microbial contamination slow down ripening bananas. As result, compared SA-coated uncoated SA-AgNNPs-coated lowest weight total bacterial colonies, thus greatly extending life. Particularly when coated films, colonies (TBC) banana peel pulp low 1.13 × 103 51 CUF/g on ninth day storage, respectively. Our work offers efficient strategy improve quality period, extensive applications fruit preservation food packing.

Language: Английский

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Reaction‐Induced Self‐Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Polymyxins have been regarded as an efficient therapeutic against many life‐threatening, multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and emergence of drug resistance associated with polymyxins greatly hindered their clinical potential. Herein, reaction‐induced self‐assembly (RISA) natural aldehydes in aqueous solution is presented. The resulting assemblies effectively mask positively charged nature polymyxins, reducing cytotoxicity. Moreover, representative PMB A 4 (composed polymyxin B (PMB) ( E )‐2‐heptenal )) demonstrate enhanced binding to outer membranes exhibit multiple antimicrobial mechanisms, including increased membrane permeability, elevated metabolism, suppression quorum sensing, reduced ATP synthesis, potential reduction resistance. Remarkably, reverse clinically isolated drug‐resistant strains bacteria, demonstrating exceptional efficacy preventing eradicating biofilms. efficiently eradicate biofilm infections vivo alleviate inflammatory response. This RISA strategy offers a practical applicable approach minimize side effects, resistance, prevent free polymyxins.

Language: Английский

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