Nanotechnology of carbon dots with their hybrids for biomedical applications: A review

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153915 - 153915

Published: July 14, 2024

Language: Английский

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Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual delivery bioefficacy are extremely restricted by their poor solubility, interior gastrointestinal retention, base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed a quaternary ammonium chitosan (HTCC) shell succinic acid-modified γ-cyclodextrin (SACD) core precise UC treatment. Egg white-derived peptides (EWDP, typical food-derived peptides) could not only function as potential cross-linkers to induce differential coassembly with above biopolymers but also aid hydrophobic curcumin (Cur) solubility well nutrition enhancers oral synergism therapy. More specifically, NPs higher EWDP efficiency exhibited better pH-sensitive colloidal tunability (e.g., smaller size, rigidity, roughness) robust (EWDP/Cur) coloading capacity (24.0–33.2% ≫ 10%, pH 2.0–7.0). Compared pure nutraceuticals, excellent cellular absorption (almost 10 times) bioavailability (4.19–5.05 enhancement via faster mucus permeation macropinocytosis transport, indirectly regulating systemic inflammatory response. The sustainable sequential release targeted accumulation profiles directly facilitated interactions colonic microenvironment, verified intestinal barrier recovery gut microbiota restoration. Moreover, critical role amino acid metabolism reconfirmed importance maintaining homeostasis. Overall, this study would provide facile, quantitative, versatile perspective into programmable design peptide EWDP) coassembled nanoplatforms UC.

Language: Английский

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Nanomaterial-mediated self-calibrating biosensors for ultra-precise detection of food hazards: Recent advances and new horizons

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216204 - 216204

Published: Sept. 10, 2024

Language: Английский

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Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet–Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(9)

Published: Sept. 1, 2024

Microplastics (MPs) have become a global environmental problem, emerging as contaminants with potentially alarming consequences. However, long-term exposure to polystyrene microspheres (PS-MS) and its effects on diet-induced obesity are not yet fully understood.

Language: Английский

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Impact of Whey Protein Corona Formation around TiO₂ Nanoparticles on Their Physiochemical Properties and Gastrointestinal Fate

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(9), P. 4958 - 4976

Published: Feb. 21, 2024

Previously, we found that whey proteins form biomolecular coronas around titanium dioxide (TiO

Language: Английский

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Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots

Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122547 - 122547

Published: March 22, 2024

Language: Английский

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Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116430 - 116430

Published: May 7, 2024

Copper (Cu) serves as an essential cofactor in all organisms, yet excessive Cu exposure is widely recognized for its role inducing liver inflammation. However, the precise mechanism by which triggers inflammation ducks, particularly relation to interplay gut microbiota regulation, has remained elusive. In this investigation, we sought elucidate impact of on through gut-liver axis ducks. Our findings revealed that markedly elevated AST and ALT levels induced upregulating pro-inflammatory cytokines (IL-1β, IL-6 TNF-α) triggering LPS/TLR4/NF-κB signaling pathway. Simultaneously, alterations composition intestinal flora communities, notably increasing relative abundance Sphingobacterium, Campylobacter, Acinetobacter reducing Lactobacillus. significantly decreased protein expression related barrier (Occludin, Claudin-1 ZO-1) promoted secretion cytokines. Furthermore, correlation analysis was observed microbiome were closely Fecal transplantation (FMT) experiments further demonstrated microbiota-depleted ducks transplanting fecal samples from Cu-exposed disturbed dysfunction, lead impaire function activate study provided insights into regulation axis. These results enhanced our comprehension potential mechanisms driving Cu-induced hepatotoxicity avian species.

Language: Английский

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Gut microbiota dysbiosis mediates mouse kidney fibrosis induced by black phosphorus quantum dots

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102203 - 102203

Published: Feb. 15, 2024

Language: Английский

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Bacteroides fragilis aggravates high-fat diet-induced non-alcoholic fatty liver disease by regulating lipid metabolism and remodeling gut microbiota

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(4)

Published: Feb. 27, 2024

Gut microbiota dysbiosis is a prominent determinant that significantly contributes to the disruption of lipid metabolism. Consequently, it essential occurrence and development non-alcoholic fatty liver disease (NAFLD). Nevertheless, connection between diet symbiotic gut in progression NAFLD remains uncertain. The purpose this study was explore role supplementing commensal Bacteroides fragilis (B. fragilis) on metabolism, microbiota, metabolites high-fat (HFD)-fed mice, elucidating impact NAFLD. Our revealed supplementation with B. exacerbated both weight gain obesity mice. blood glucose levels dysfunction Furthermore, an increase accumulation upregulation genes correlated metabolism were observed Under HFD, resulted alterations notably significant Desulfovibrionaceae, which led elevated endotoxin thereby influenced It interesting simultaneous examination more pronounced short-chain acids. This represented pioneering investigation into findings demonstrated induced dysregulation intestinal leading lipopolysaccharide exacerbating NAFLD.IMPORTANCESome microbes are involved metabolic disorders. investigated host diet-fed Research results indicated adding specific bacterial strain complex microecology can worsen conditions. effect mainly affects structural diversity microorganisms, harmful bacteria gut, elevation levels, glucose, impacting Understanding principles govern establishment microbial communities comprising multiple species crucial for preventing or repairing dysfunctions these communities, enhancing health facilitating treatment. could contribute provides new insights how promote prevention therapy

Language: Английский

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Insight into the synthetic strategies of carbon dots and its Structure-Property interplay for Next-Generation technologies

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153914 - 153914

Published: July 13, 2024

Language: Английский

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