Drug-Free Multi-Modal Non-invasive Cancer Therapy via Oxygen Vacancy Engineered Biomimetic Cerium Oxide Nanozymes DOI Creative Commons
Sayoni Sarkar,

Diksha Malhotra,

Monalisha Debnath

et al.

Published: Jan. 5, 2024

Contemporary challenges in chemotherapy for triple negative breast cancer (TNBC) are inadequate specificity towards malignant cells, constraints imposed by dose-related toxicities, and side effects on normal cells. To address these bottlenecks, our study introduces, a drug-free “trojan horse-like” folate functionalized, L-arginine-coated ceria (FA-L-arg-CeO2) nanoplatform treating metastatic TNBC. We show that this engineered nanozyme exhibiting enhanced surface oxygen vacancies (VO●) facilitated band structure reconstruction amplified the photothermal/photodynamic therapeutic (PTT/PDT) efficacy under single laser irradiation (808 nm) through reactive species (ROS) production, thereby outperforming defect-free commercial nano-CeO2 rapid tumour ablation (86% 48 h). This low-cost targeted therapy substantial receptor-mediated endocytosis accumulation of biostable nanozymes MDA-MB-231 cells (84% These VO●-rich FA-L-arg-CeO2 nanostructures were found to exhibit distinctive pH-active multi-enzyme mimicking characteristics, imparting exceptional potential effectively inhibited cell metastasis (62% within 12 Mechanistically, we observed electrons generated at during modulate pH-responsive intracellular redox balance, synergistically killing safeguarding benign L929 Unlike drug-loaded CeO2-based nanoplatforms, protected healthy from radiation damage photo-triggered-ROS scavenging catalase. novel, nanozyme-based leads way smart, bio-inspired multi-modal treatments, ensuring bio-safety.

Language: Английский

An AND Logic Gate for Magnetic‐Resonance‐Imaging‐Guided Ferroptosis Therapy of Tumors DOI Open Access
Qingdeng Fan, Wei Xiong, Huimin Zhou

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(45)

Published: Sept. 17, 2023

To improve the magnetic resonance imaging (MRI) efficiency and ferroptosis therapy efficacy of exceedingly small iron oxide nanoparticles (IO, <5 nm) for tumors via enhancing sensitivity tumor microenvironment (TME) responsiveness, inspired by molecular logic gates, a self-assembled IO with an AND gate function is designed constructed. Typically, cystamine (CA) conjugated onto end poly(2-methylthio-ethanol methacrylate) (PMEMA) to generate PMEMA-CA. The PMEMA-CA grafted surface brequinar (BQR)-loaded form IO-BQR@PMEMA. IO-BQR@PMEMA (SA-IO-BQR@PMEMA) obtained due hydrophobicity PMEMA. carbon-sulfur single bond can be oxidized reactive oxygen species (ROS) in TME thio-oxygen double bond, resulting conversion from being hydrophobic hydrophilic. disulfide broken glutathione (GSH) TME, leading shedding PMEMA surface. Under dual actions ROS GSH (i.e., gate), SA-IO-BQR@PMEMA disassembled release IO, Fe2+/3+ , BQR. In vitro vivo results demonstrate mechanism, high T1 MRI performance exceptional tumors, excellent biosafety SA-IO-BQR@PMEMA.

Language: Английский

Citations

57
Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications DOI
Rupam Dinda, Eugenio Garribba, Daniele Sanna

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment living beings. The different reactions that vanadium compounds (VCs) undergo presence of proteins, nucleic acids, lipids metabolites under mild physiological conditions are reviewed. In present naturally or through anthropogenic sources, latter having an environmental impact caused by dispersion VCs atmosphere aquifers. has versatile chemistry interconvertible oxidation states, variable coordination number geometry, ability to form polyoxidovanadates various nuclearity structures. If VC added water-containing it can hydrolysis, ligand-exchange, redox, other types changes, determined speciation vanadium. Importantly, solution likely differ from introduced into system varies concentration. Here, hydrolytic ligand-exchange chemical reactions, influence pH, concentration, salt, specific solutes, biomolecules, on described. One our goals this work highlight need for assessment speciation, so beneficial toxic species might be identified mechanisms action elucidated.

Language: Английский

Citations

3
MOFs‐Based Magnetic Nanozyme to Boost Cascade ROS Accumulation for Augmented Tumor Ferroptosis DOI
Ying Yuan, Bo Chen,

Xingxing An

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: March 26, 2024

The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. A metal-organic frameworks (MOFs)-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid, delivering excellent magnetophotonic response efficient ferroptosis, is reported here. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase-like catalysis to generate O

Language: Английский

Citations

11
Peptide‐Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy DOI

Xiaolin Duan,

Pin Wang,

Lulu He

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(37)

Published: Feb. 9, 2024

Abstract The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity integration imaging therapeutic functions. multifaceted nature inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class materials that emerged in this context are peptide‐functionalized (PFIONs), demonstrated excellent performance therapy, making potential candidates advancing tumor treatment. Owing to the functionalities peptides targeting, penetration, responsiveness, well‐designed PFIONs can specifically accumulate release or agents at sites, enabling precise effective This review provides an overview recent advances use tumors, highlighting superiority as well synergistic Moreover, discusses challenges prospects depth, aiming promote intersection interdisciplinary facilitate their clinical translation development personalized diagnostic systems optimizing material systems.

Language: Английский

Citations

10
Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy DOI Creative Commons
Hai Zhu, Tinghua Li, Xinhao Peng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field

Language: Английский

Citations

1
Sonodynamic Activated Nanoparticles with Glut1 Inhibitor and Cystine-containing Polymer Stimulate Disulfidptosis for Improved Immunotherapy in Bladder Cancer DOI Creative Commons
Ke Wang, Li Li,

Ganghao Liang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123178 - 123178

Published: Feb. 8, 2025

Language: Английский

Citations

1
Lonidamine liposomes to enhance photodynamic and photothermal therapy of hepatocellular carcinoma by inhibiting glycolysis DOI Creative Commons
Lei Lei, Wenbin Dai,

Jiaping Man

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 15, 2023

Abstract Phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), has great promise in the treatment of cancer. However, there are many obstacles that can restrict therapeutic efficacy phototherapy. The hypoxic tumor microenvironment production reactive oxygen species (ROS) PDT. As for PTT, thermotolerance cancer cells may lead to ineffective PTT. In this study, IR780 glycolysis inhibitor lonidamine (LND)-encapsulated liposomes prepared hepatocellular carcinoma. be used as a photosensitizer agent simultaneous PDT PTT after being irradiated with 808 nm laser. LND reduce consumption by inhibiting glycolysis, which will relieve hypoxia produce more ROS On other hand, energy supply blocked LND-induced inhibition, inhibit heat shock proteins (HSPs), cells, finally enhance enhanced is studied measuring intracellular HSPs, ATP level, mitochondrial membrane potential. antitumor effect co-loaded extensively investigated vitro vivo experiments. This research provides an innovative strategy simultaneously promising future creative approaches

Language: Английский

Citations

18
Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective DOI
Zifan Pei,

Longxiao Li,

Nailin Yang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969

Published: June 10, 2024

Language: Английский

Citations

7
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

7
Fe/Co bimetallic nanozyme disrupting tumorous Self-Regulatory pathways to potentiate ferroptosis DOI
Qing Liu, Qian Chen,

Xi Deng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152753 - 152753

Published: June 1, 2024

Language: Английский

Citations

5