Self‐Carrier Nanoparticles for Delivery of Paclitaxel and IDO Inhibitor to Boost Antitumor Chemo‐Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: March 21, 2024

Abstract The combination of chemotherapy and immunotherapy holds great potential in clinical treatment advanced cancers. Whereas, the therapeutic outcome chemotherapeutic immune regulator is suboptimal due to their poor tumor availability severe off‐target toxicity. Herein, self‐carrier nanoparticles (PSMT NPs) integrating a paclitaxel (PTX) prodrug indoleamine 2,3‐dioxygenase 1 (IDO) inhibitor (1‐methyl‐tryptophan, 1MT) for tumor‐specific chemo‐immunotherapy constructed. After internalization by cancer cells, PSMT NPs can respond endogenous redox stimulus, release PTX 1MT. released not only promote cell apoptosis via intervention mitosis but also initiate immunogenic death facilitate recruitment activation tumor‐infiltrating cytotoxic T lymphocytes. concomitant 1MT inhibit IDO activity exhaust regulatory thereby synergistically activating exhibit potentiated antitumor output toward triple‐negative breast negligible systemic This facile versatile nanoplatform provides promising strategy cooperatively activate immunity chemo‐immunotherapy.

Language: Английский

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Spiky metal-organic framework nanosystem for enhanced cuproptosis-mediated cancer immunotherapy

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102231 - 102231

Published: March 21, 2024

Immunotherapy, particularly αPD-1 therapy, has been hailed as a significant breakthrough in cancer treatment. However, the limited response rates and unknown mechanisms hinder clinical application of blockade boosting with hybrid nanoparticles. Herein, we introduce strategy to enhance immunotherapy by leveraging cuproptosis, initiated spiky copper-based metal-organic framework (S@Cu-MOF) loaded polyphyllin I (PPI) synergized therapy. Interestingly, unique structure S@Cu-MOF not only significantly enhances tumor cell uptake but also leads pronounced DNA damage. The S@Cu-MOF/PPI therapy led obvious regression prolonged survival due which involved substantial mitochondrial This process amplifies cGAS/STING immune pathway, enhancing against cancer. Additionally, this promoted immunogenic death (ICD), recruitment mature dendritic cells (DCs), T cell-mediated immunity, effective memory CD8+ cells, resulting abscopal suppression lung metastasis reduction. Our study highlights potential sensitizer for mechanism cuproptosis offering promising next generation immunotherapy.

Language: Английский

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Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6137 - 6151

Published: Oct. 1, 2023

Intelligent hydrogels continue to encounter formidable obstacles in the field of cancer treatment. A wide variety hydrogel materials have been designed for diverse purposes, but with satisfactory therapeutic effects are still urgently needed.Here, we prepared an injectable by means physical crosslinking. Carbon nanoparticle suspension injection (CNSI), a sentinel lymph node imaging agent that has widely used clinic, sodium β-glycerophosphate (β-GP) were added temperature-sensitive chitosan (CS) (CS/GP@CN) as photothermal therapy (PTT). After evaluating rheological, morphological, and structural properties hydrogel, 4T1 mouse breast cells B16 melanoma assess its vitro properties. Then, intratumorally injected into BALB/c tumor-bearing mice vivo PTT effect, antitumor immune response number lung metastases.Surprisingly, this nanocarbon called CS/GP@CN not only had good biocompatibility great effect under 808nm laser irradiation also facilitated maturation dendritic stimulate extraordinary antimetastatic lungs.Overall, innovative which exists liquid state at room temperature transforms gel 37 °C, is outstanding local delivery platform tremendous potential broad clinical application prospects.

Language: Английский

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Synthetic fungal melanin UV absorbers

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(9), P. 3098 - 3110

Published: Aug. 13, 2024

Language: Английский

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Engineering Phage Nanocarriers Integrated with Bio‐Intelligent Plasmids for Personalized and Tunable Enzyme Delivery to Enhance Chemodynamic Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(24)

Published: April 6, 2024

Abstract Customizable and number‐tunable enzyme delivery nanocarriers will be useful in tumor therapy. Herein, a phage vehicle, T4‐Lox‐DNA‐Fe (TLDF), which adeptly modulates numbers using display technology to remodel the microenvironment (TME) is presented. Regarding demand for lactic acid tumors, each engineered 720 lactate oxidase (Lox), contributing depletion of restructure tumor's energy metabolism. The vehicle incorporated dextran iron (Fe) with Fenton reaction capabilities. H 2 O generated through Lox catalytic reaction, amplifying supply iron‐based chemodynamic therapy (CDT). Drawing inspiration from erythropoietin (EPO) biosynthetic process, an EPO enhancer constructed impart EPO‐Keap1 plasmid (DNA) hypoxia‐activated functionality, disrupting redox homeostasis TME. consumes local oxygen, positive feedback between promotes expression kelch ECH Associated Protein 1 (Keap1). Consequently, downregulation antioxidant transcription factor Nrf2, synergy CDT, amplifies oxidative killing effect, leading suppression up 78%. This study seamlessly integrates adaptable T4 vehicles bio‐intelligent plasmids, presenting promising approach

Language: Английский

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Potent Amphiphilic Poly(Amino Acid) Nanoadjuvant Delivers Biomineralized Ovalbumin for Photothermal-Augmented Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(46), P. 32088 - 32102

Published: Nov. 8, 2024

Cancer nanovaccines have emerged as an indispensable weapon for tumor treatment. However, insufficient immunogenicity and immunosuppression hamper the therapeutic effects of nanovaccines. Here, biodegradable (OMPP) composed ovalbumin (OVA)-manganese oxide nanoparticles, amphiphilic poly(γ-glutamic acid) (γ-PGA), ε-polylysine (PL) are constructed to realize enhanced cancer immunotherapy. Interestingly, γ-PGA PL could serve both carriers immunoadjuvants promote cytosolic delivery antigens enhance maturation dendritic cells. Additionally, taking advantage photothermal property OMPP, immunogenic cell death in situ release tumor-associated can be triggered under near-infrared light irradiation personalized Moreover, OMPP efficiently alleviate hypoxia downregulate programmed death-ligand 1 expression reprogram immunosuppressive microenvironment. OMPP-mediated therapy has been shown provoke robust immune responses suppress B16-OVA melanoma prevent postsurgical recurrence. This work presents a facile strategy fabrication by integrating carrier adjuvant while exploring inherent properties antigen modulate immunosuppression, which demonstrates great potential effective

Language: Английский

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Genetically Designed Living Bacteria with Melanogenesis for Tumor‐Specific Pigmentation and Therapeutic Intervention

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 18, 2024

Abstract Visual observation and therapeutic intervention against tumors hold significant appeal for tumor treatment, particularly in meeting the demands of intraoperative navigation. From a clinical perspective, naked‐eye visualization provides direct convenient approach to identifying navigating during surgery. Nevertheless, there is an ongoing need develop effective solutions this frontier. Genetically engineered microorganisms are promising as living therapeutics combatting malignant tumors, leveraging precise targeting versatile programmed functionalities. Here, genetically modified Escherichia coli ( E. ) MG1655 bacterial cells introduced, called MelaBac cells, designed express tyrosinase continuously. This bioengineered melanogenesis produces melanin capable pigmenting both subcutaneous CT26 xenografts chemically induced colorectal cancer (CRC). Additionally, demonstrate initiation photonic hyperthermia therapy immunotherapy offering selective interventions with high biocompatibility.

Language: Английский

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Bacterial outer membrane vesicles-clothed nanoparticles delivered by live macrophages for potentiating antitumor photoimmunotherapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156420 - 156420

Published: Oct. 5, 2024

Language: Английский

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Radiation-activated PD-L1 aptamer-functionalized nanoradiosensitizer to potentiate antitumor immunity in combined radioimmunotherapy and photothermal therapy

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(47), P. 12220 - 12231

Published: Jan. 1, 2024

This gold–MnO 2 nanoradiosensitizer enhances radioimmunotherapy by boosting ROS production, triggering immunogenic cell death, and effectively suppressing tumor growth metastasis.

Language: Английский

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General Introduction and Background of Photofunctional Nanomaterials in Biomedical Applications

Published: Jan. 3, 2025

Photofunctional nanomaterials have shown great potential in biomedical applications due to their unique optical properties and size effects. This chapter focuses on "General Introduction Background of Nanomaterials Biomedical Applications." First, a brief introduction is given, describing basic importance various fields. Secondly, the concepts photofunctional physicochemical effects under light conditions, such as photothermal effect, photoluminescence, photovoltaic photochemical are presented. Next, an overview nanobiomedicine presented, highlighting for applications. Then, different types nanomaterials, including fluorescent, photothermal, photodynamic, photoelectrochemical photoacoustic discussed detailed classification fields bioimaging, antimicrobial, oncological diagnosis treatment, biodetection sensing discussed. Finally, current research results summarized future development field envisaged.

Language: Английский

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