Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 24, 2024
Abstract
Photothermal
therapy
(PTT)
is
a
promising
cancer
treatment
method
due
to
its
ability
induce
tumor-specific
T
cell
responses
and
enhance
therapeutic
outcomes.
However,
incomplete
PTT
can
leave
residual
tumors
that
often
lead
new
metastases
decreased
patient
survival
in
clinical
scenarios.
This
primarily
the
release
of
ATP,
damage-associated
molecular
pattern
quickly
transforms
into
immunosuppressive
metabolite
adenosine
by
CD39,
prevalent
tumor
microenvironment,
thus
promoting
immune
evasion.
study
presents
photothermal
nanomedicine
fabricated
electrostatic
adsorption
among
Fe-doped
polydiaminopyridine
(Fe-PDAP),
indocyanine
green
(ICG),
CD39
inhibitor
sodium
polyoxotungstate
(POM-1).
The
constructed
Fe-PDAP@ICG@POM-1
(FIP)
immunogenic
death
when
exposed
near-infrared
laser.
Significantly,
it
inhibit
ATP-adenosine
pathway
dual-directional
immunometabolic
regulation,
resulting
increased
ATP
levels
synthesis,
which
ultimately
reverses
microenvironment
increases
susceptibility
checkpoint
blockade
(aPD-1)
therapy.
With
aid
aPD-1,
regulation
strategy
mediated
FIP
effectively
suppress/eradicate
primary
distant
evoke
long-term
solid
immunological
memory.
an
control
offer
salvage
option
for
treating
following
PTT.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: March 23, 2024
Abstract
Triple
negative
breast
cancer
(TNBCs),
known
as
an
immunologically
cold
tumor,
is
difficult
to
completely
eliminate
with
existing
monotherapies,
let
alone
metastasis
and
recurrence.
It
urgent
design
a
rational
combination
of
multiple
therapies
programmatically
reconstitute
tumor
microenvironment
(TME)
reverse
the
immune
“cold”
into
“hot”
inflammatory
tumors
improve
therapeutic
effect.
Hence,
in
this
work,
multifunctional
nanosystem
(FeSH
NPs)
that
integrates
metal‐polyphenol
coordination
complex
photothermal
agent
polyphenol,
salvianolic
acid
B
(SAB)
immunomodulator
designed
fabricated
for
synergistic
photothermal‐immunotherapy
TNBCs
combined
anti‐PD‐L1
antibody.
Guided
by
photothermal/photoacoustic
dual‐mode
imaging,
therapy
(PTT)
caused
FeSH
NPs
induces
immunogenic
cell
death
(ICD)
under
808
nm
laser
irradiation.
Subsequently,
loaded
SAB
released
addition
deferoxamine
mesylate
(DFO)
remodel
TME,
specifically
TGF‐β
inhibition
PD‐L1
upregulation,
primary
tumors.
The
PTT
TME
reprogramming
further
synergizes
antibody
eradicate
recurrence
inhibit
concurrently.
Given
biosafety
throughout
lifecycle,
work
provides
protocol
high
clinical
translational
promise
comprehensive
programmed
therapeutics
TNBCs.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(36), P. 25144 - 25154
Published: Aug. 27, 2024
Near-infrared
II
(NIR-II)
imaging
and
photothermal
therapy
hold
tremendous
potential
in
precision
diagnosis
treatment
within
biological
organisms.
However,
a
significant
challenge
is
the
shortage
of
NIR-II
fluorescent
probes
with
both
high
conversion
coefficient
(PCE)
fluorescence
quantum
yield
(Φ
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 22, 2025
Triple-negative
breast
cancer
(TNBC)
is
a
highly
aggressive
subtype
of
characterized
by
an
extremely
poor
prognosis.
Photoimmunotherapy
has
emerged
as
promising
strategy
for
the
treatment
TNBC.
This
approach
works
selectively
destroying
tumor
cells,
releasing
tumor-associated
antigens,
activating
immune
system,
and
effectively
inhibiting
proliferation
metastasis.
However,
majority
current
phototheranostic
approaches
are
hindered
limited
tissue
penetration
in
first
near-infrared
(NIR-I)
ultraviolet–visible
(UV–Vis)
regions.
Additionally,
due
to
lack
specific
subcellular
targets,
it
may
be
difficult
treat
deep-seated
lesions
with
ambiguous
extensive
boundaries
caused
TNBC
metastases.
Consequently,
development
effective,
deep-penetrating,
organelle-targeted
phototheranostics
essential
enhancing
outcomes
work
proposes
novel
molecular
design
NIR-II
realize
planar
rigid
conjugation
alkyl
chain
functionalization.
The
di-hexaalkyl
chains
vertical
configuration
on
donor
(4H-cyclopenta[2,1-b:3,4-b']
dithiophene)
shielding
units
(fluorene)
introduced
construct
S-D-A-D-S
type
(IR-FCD).
structure
IR-FCD
exhibits
robust
intramolecular
charge
transfer
capability,
lower
band
gap,
enhanced
photon
absorption
properties,
significant
steric
hindrance
from
vertically
arranged
minimize
non-radiative
energy
loss.
By
incorporating
N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide
at
terminus
elongated
chain,
followed
self-assembly
into
DSPE-S-S-PEG2000,
excitable
(IR-FCD-Ts
NPs)
endoplasmic
reticulum
(ER)
targeting
capability
were
successfully
synthesized
imaging-guided
photoimmunotherapy
IR-FCD-Ts
NPs
demonstrate
exceptional
optical
characteristics,
maximum
1068
nm
(extending
1300
nm)
emission
1273
1700
nm),
along
high
molar
coefficient
2.76*104
L/mol·c
1064
aqueous
solution.
Under
exposure
laser
irradiation,
exhibit
superior
photothermal
properties
have
potential
photodynamic
therapy.
ER,
thereby
inducing
ER
stress
significantly
immunogenic
cell
death
(ICD)
triggers
strong
antitumor
response
inhibits
metastasis
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(29), P. 38377 - 38386
Published: July 12, 2024
Photothermal
therapy
(PTT)
holds
great
potential
in
the
field
of
cancer
treatment
due
to
its
high
specificity
and
low
invasiveness.
However,
conversion
efficiency,
inadequate
tumor
accumulation,
limited
cellular
uptake
continue
impede
PTT
effectiveness
treating
tumors.
The
present
study
focuses
on
utilization
quinoxaline
nanoparticles
develop
an
organic
semiconducting
photothermal
agent
(PAQI-BDTT)
for
therapy.
To
achieve
this,
PAQI-BDTT
was
encapsulated
within
liposomes
modified
with
cyclic
Arg-Gly-Asp
(cRGD)
peptide
targeting
tumors
(named
T-BDTT-Lipo).
Notably,
T-BDTT-Lipo
demonstrated
a
positive
efficiency
74%
when
exposed
808
nm
laser,
along
NIR-II
fluorescence
imaging
capabilities.
efficacy
tissue
accumulation
precise
malignant
cells
has
been
confirmed
through
both
vitro
vivo
experiments
guided
by
imaging.
Under
single
dose
light
irradiation,
generated
local
intracellular
hyperthermia
at
site.
elevated
temperature
additionally
exerted
significant
inhibitory
effect
growth
recurrence,
thereby
extending
survival
duration
mice
harboring
therapeutic
nanosystem
(T-BDTT-Lipo)
proposed
this
work
demonstrates
enormous
agents
therapy,
laying
foundation
next
clinical
application.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: July 15, 2024
Abstract
Mild
photothermal
therapy
(PTT)
has
attracted
attention
for
effectively
avoiding
the
severe
side
effects
associated
with
high‐temperature
tumor
ablation.
However,
its
progress
is
hindered
by
limited
availability
of
high‐performance
agents
(PTAs)
and
thermoresistance
cancer
cells
induced
heat
shock
reactions.
Herein,
this
work
proposes
a
new
strategy
to
expand
library
organic
small‐molecule
PTAs
utilize
it
construct
multifunctional
nano‐theranostic
platform.
By
incorporating
additional
acceptors
appropriate
π‐bridges,
diketopyrrolopyrrole‐based
dye
BDB
developed,
which
exhibits
strong
absorption
bright
fluorescence
emission
in
near‐infrared
(NIR)
region.
Subsequently,
co‐coated
protein
(HSP)
inhibitor
tanespimycin
(17‐AAG)
using
functional
amphiphilic
polymers
DSPE‐Hyd‐PEG
2000
‐cRGD
form
an
all‐in‐one
nanoplatform
BAG
NPs.
As
result,
NPs
can
precisely
target
tissue,
guide
treatment
process
real‐time
through
NIR‐II
fluorescence/photoacoustic/photothermal
imaging,
release
17‐AAG
on
demand
enhance
mild
PTT.
Additionally,
PTT
been
demonstrated
induce
immunogenic
cell
death
(ICD)
activate
systemic
anti‐tumor
immune
response,
thereby
suppressing
both
primary
distant
tumors.
Overall,
study
presents
designed
precise
combined
immunotherapy
effective
treatment.
Regenerative Biomaterials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
In
this
article,
we
fabricated
nanomedicines
with
mitochondrial
targeting
function
and
autophagy
inhibitor
for
enhancing
cancer
photothermal-chemotherapy.
The
nanoparticles
were
gold
(AuNPs)
as
cores
amphiphilic
dextran
(3-carboxypropyl)
triphenyl
phosphorus
bromide
β-cyclodextrin
(β-CD)
modification
(TPP-DCD)
shells;
the
chemotherapeutic
doxorubicin
(DOX)
chloroquine
(CQ)
encapsulated
in
nanoparticles.
TPP-DCD
was
synthesized
via
immobilization
of
2-aminoethanethiol
modified
β-CD
triphenylphosphonium
on
to
receive
coordination
interaction
AuNPs
mitochondria
targeting.
size,
morphology
properties
Au@DOX/CQ@TPP-DCD
studied.
efficiently
targeted
cellular
produce
reactive
oxygen
species
photothermal
effect
under
NIR
irradiation.
released
DOX
CQ
could
not
only
kill
tumor
cells
directly,
but
also
inhibit
enhance
therapeutic
effects.
Both
vitro
vivo
anticancer
activities
investigated
detail.
imaging
demonstrated
that
exhibited
efficient
targeting,
accumulation
retention
tumor-bearing
mice.
apoptosis
suppression
greatly
accelerated
addition
808
nm
nanomedicine
significant
synergistic
therapy,
75%
tumors
mice
disappeared.
nanoparticle
is
a
promising
therapy
