Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(40), P. 15915 - 15923
Published: Sept. 26, 2024
Accurate monitoring of base excision repair (BER) activity in cancer cells is critical for advancing the comprehension DNA processes, gaining insights into development, and guiding treatment strategies. However, current assay techniques assessing BER face challenges due to heterogeneous origins diversity enzymes. In this work, we present a hi
Language: Английский
Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417
Published: Jan. 1, 2023
Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.
Language: Английский
Citations
147
Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)
Published: Nov. 21, 2023
Since the discovery of enzyme-like activity Fe
Language: Английский
Citations
65
Cell Death and Differentiation, Journal Year: 2024, Volume and Issue: 31(4), P. 431 - 446
Published: Feb. 28, 2024
Language: Английский
Citations
21
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Language: Английский
Citations
4
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: March 7, 2025
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both onset progression of various diseases. Under physiological conditions, oxidative free radicals generated by mitochondrial respiratory chain, endoplasmic reticulum, NADPH oxidases can be effectively neutralized NRF2-mediated antioxidant responses. These responses elevate synthesis superoxide dismutase (SOD), catalase, well key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH), thereby maintaining cellular redox homeostasis. Disruption this finely tuned equilibrium is closely linked to pathogenesis wide range Recent advances have broadened our understanding molecular mechanisms underpinning dysregulation, highlighting pivotal roles genomic instability, epigenetic modifications, protein degradation, metabolic reprogramming. findings provide foundation for exploring regulation mechanistic basis improving therapeutic strategies. While antioxidant-based therapies shown early promise conditions where stress plays primary pathological role, efficacy diseases characterized complex, multifactorial etiologies remains controversial. A deeper, context-specific signaling, particularly redox-sensitive proteins, designing targeted aimed at re-establishing balance. Emerging small molecule inhibitors that target specific cysteine residues proteins demonstrated promising preclinical outcomes, setting stage forthcoming clinical trials. In review, we summarize current intricate relationship disease also discuss how these insights leveraged optimize strategies practice.
Language: Английский
Citations
3
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(22)
Published: March 29, 2024
The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, low response limits immunotherapy efficiency. Here, we report a ROS-responsive Fe
Language: Английский
Citations
14
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215842 - 215842
Published: April 15, 2024
Language: Английский
Citations
14
Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122570 - 122570
Published: April 15, 2024
Language: Английский
Citations
13
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(37)
Published: Feb. 9, 2024
Abstract The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity integration imaging therapeutic functions. multifaceted nature inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class materials that emerged in this context are peptide‐functionalized (PFIONs), demonstrated excellent performance therapy, making potential candidates advancing tumor treatment. Owing to the functionalities peptides targeting, penetration, responsiveness, well‐designed PFIONs can specifically accumulate release or agents at sites, enabling precise effective This review provides an overview recent advances use tumors, highlighting superiority as well synergistic Moreover, discusses challenges prospects depth, aiming promote intersection interdisciplinary facilitate their clinical translation development personalized diagnostic systems optimizing material systems.
Language: Английский
Citations
10
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101027 - 101027
Published: March 16, 2024
Multimodal imaging, which combines the strengths of two or more imaging modalities to provide complementary anatomical and molecular information, has emerged as a robust technology for enhancing diagnostic sensitivity accuracy, well improving treatment monitoring. Moreover, application multimodal in guiding precision tumor can prevent under- over-treatment, thereby maximizing benefits patients. In recent years, several intriguing magneto-optical nanosystems with both magnetic optical properties have been developed, leading significant breakthroughs field image-guided therapy. These advancements pave way precise medicine. This review summarizes various types developed recently describes their applications probes agents therapeutic interventions. Finally, future research development prospects are discussed along an outlook on further biomedical field.
Language: Английский
Citations
10