Multi-stage mechanisms of tumor metastasis and therapeutic strategies

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 11, 2024

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at numerous phases the disease and progress under intense evolutionary pressures. Organ-specific relies on formation pre-metastatic niche (PMN), with diverse cell types complex interactions contributing to this concept, adding a new dimension traditional cascade. Prior metastatic dissemination, as orchestrators PMN formation, primary tumor-derived extracellular vesicles prepare fertile microenvironment for settlement colonization circulating cells distant secondary sites, significantly impacting cancer progression outcomes. Obviously, solely intervening sites passively after macrometastasis is often insufficient. Early prediction holistic, macro-level control represent future directions therapy. This review emphasizes dynamic intricate systematic alterations that progresses, illustrates immunological landscape creation, deepens understanding treatment modalities pertinent metastasis, thereby identifying some prognostic predictive biomarkers favorable early predict occurrence design appropriate combinations.

Language: Английский

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Advanced zwitterionic polymeric membranes for diverse applications beyond antifouling

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: unknown, P. 129848 - 129848

Published: Sept. 1, 2024

Language: Английский

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Enabling tumor-specific drug delivery by targeting the Warburg effect of cancer

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101920 - 101920

Published: Jan. 1, 2025

Metabolic reprogramming of tumor cells is an emerging hallmark cancer. Among all the changes in cancer metabolism, increased glucose uptake and accumulation lactate under normoxic conditions (the "Warburg effect") a common feature cells. In this study, we develop lactate-responsive drug delivery platform by targeting Warburg effect. We design test gold/mesoporous silica Janus nanoparticle system as gated carrier, which gold particles are functionalized with oxidase capped α-cyclodextrin through surface arylboronate modification. presence lactate, generates hydrogen peroxide, induces self-immolation reaction arylboronate, leading to uncapping release. Our results demonstrate greatly improved specificity therapeutic efficacy for treatment different cancers. findings present effective approach metabolic tumors.

Language: Английский

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Hydrogel-based platforms for site-specific doxorubicin release in cancer therapy

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 30, 2024

Language: Английский

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Dismantlable Coronated Nanoparticles for Coupling the Induction and Perception of Immunogenic Cell Death

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: April 21, 2024

Abstract Therapy‐induced immunogenic cell death (ICD) can initiate both innate and adaptive immune responses for amplified anti‐tumor efficacy. However, dying cell‐released ICD signals are prone to being sequestered by the TIM‐3 receptors on dendritic (DC) surfaces, preventing surveillance. Herein, dismantlable coronated nanoparticles (NPs) fabricated as a type of spatiotemporally controlled nanocarriers coupling tumor cell‐mediated induction DC‐mediated sensing. These NPs loaded with an inducer, mitoxantrone (MTO), wrapped redox‐labile anti‐TIM‐3 (αTIM‐3) antibody corona, forming separable core–shell structure. The corona disintegrates under high levels extracellular reactive oxygen species in microenvironment, exposing MTO‐loaded NP core releasing functional αTIM‐3 molecules DC sensitization. Systemic administration augments maturation, promotes cytotoxic T recruitment, enhances susceptibility checkpoint blockade, prevents side effects MTO. This study develops promising nanoplatform unleash potential host immunity cancer therapy.

Language: Английский

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Pure Zwitterionic Hydrogel with Mechanical Robustness and Dynamic Tunability Enabled by Synergistic Non‐Covalent Interactions

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Zwitterionic hydrogels with exceptional antifouling properties and biocompatibility have gained widespread attention in biomedical applications. However, achieving robust mechanical performance while maintaining high water content within a single‐network zwitterionic hydrogel remains challenging. Traditional covalent crosslinking strategies often lead to brittleness irreversible damage. Herein, novel acylsemicarbazide‐containing carboxybetaine methacrylate (ACBMA) monomer is designed synthesized that enables the construction of pure poly(ACBMA) (pACBMA) without chemical crosslinkers. The pACBMA exhibits exceeding 95% superior properties, including compressive fracture stress 3.92 MPa, strain up 99% breaking, toughness 212 ± 2.4 kJ m − 3 , outperforming chemically crosslinked poly(carboxybetaine methacrylate) (pCBMA) hydrogel. Additionally, excellent injectability, moldability, even recyclability through preparation microgels. Through unique molecular design, integrates multiple non‐covalent interactions, hydrogen bonding, electrostatic polymer chain entanglement, steric hindrance α ‐methyl group. These interactions synergistically contribute combination hydration, robustness, dynamic tunability. results provide new design strategy for constructing high‐performance promising potential diverse

Language: Английский

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Glucose-activated nanozyme hydrogels for microenvironment modulation via cascade reaction in diabetic wound

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110012 - 110012

Published: May 1, 2024

Language: Английский

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Tissue-adhesive, stretchable and compressible physical double-crosslinked microgel-integrated hydrogels for dynamic wound care

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 184, P. 186 - 200

Published: June 25, 2024

Language: Английский

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Advances in cancer diagnosis and therapy by alginate-based multifunctional hydrogels: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137707 - 137707

Published: Nov. 18, 2024

Language: Английский

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Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 181 - 197

Published: Jan. 1, 2025

Abstract: The microenvironment tends to be immunosuppressive during tumor growth and proliferation. Immunotherapy has attracted much attention because of its ability activate tumor-specific immune responses for killing. cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway is an innate that activates antitumor immunity by producing type I interferons. Cyclic dinucleotides (CDNs), produced cGAS sensing cytoplasmic abnormal DNA, are major intermediate activating molecules in the STING pathway. Nowadays, CDNs their derivatives have widely worked as powerful agonists immunotherapy. However, clinical translation hindered negative electrical properties, sensitivity hydrolytic enzymes, systemic toxicity. Recently, various CDN delivery systems made significant progress addressing these issues, either through monotherapy or combination with other treatment modalities. This review details recent advances CDNs-based pharmaceutical development strategies enriching at sites Keywords: dinucleotides, stimulator pathway, immunotherapy

Language: Английский

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