Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: unknown, P. 116873 - 116873
Published: Oct. 1, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14085 - 14122
Published: May 22, 2024
Infectious diseases pose a serious threat and substantial economic burden on global human public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless their antibiotic susceptibility. contrast conventional therapies, these approaches facilitate precise targeting pathogenic and/or infectious microenvironments, effectively minimizing toxicity mammalian cells surrounding healthy tissues. The highlighted include photodynamic therapy, photocatalytic photothermal endogenous pigments-based photobleaching polyphenols-based photo-oxidation therapy. comprehensive exploration aims offer updated information development effective, convenient, safe, alternative counter growing MDR future.
Language: Английский
Citations
30
ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17837 - 17851
Published: June 28, 2024
Currently, specific cancer-responsive fluorogenic probes with activatable imaging and therapeutic functionalities are in great demand the accurate diagnostics efficient therapy of malignancies. Herein, an all-in-one strategy is presented to realize fluorescence (FL) imaging-guided synergetic chemodynamic–photodynamic cancer by using a multifunctional alkaline phosphatase (ALP)-response aggregation-induced emission (AIE) probe, TPE-APP. By responding abnormal expression levels ALP biomarker cells, phosphate groups on AIE probe selectively hydrolyzed, accompanied situ formation strong emissive aggregates for discriminative cell over normal cells highly active quinone methide species robust activities. Consequently, activated can efficiently destroy membranes lead death within 30 min. A superior efficacy ablation demonstrated vitro vivo. The cancer-associated response-derived FL synergistic expected provide promising avenue precise image-guided therapy.
Language: Английский
Citations
15
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 9, 2024
Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.
Language: Английский
Citations
10
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(48)
Published: Oct. 13, 2024
Phototherapy, such as photothermal therapy (PTT) and photodynamic (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug-resistant significantly diminish efficiency heat conduction impede entrance reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by membrane feature competent herein MXene/CaO
Language: Английский
Citations
10
Chemical Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Facing the global "superbug" crisis due to emergence and selection for antibiotic resistance, phages are among most promising solutions. Fighting multidrug-resistant bacteria requires precise diagnosis of bacterial pathogens specific cell-killing. Phages have several potential advantages over conventional antibacterial agents such as host specificity, self-amplification, easy production, low toxicity well biofilm degradation. However, narrow range, uncharacterized properties, risks from exponential replication evolution natural phages, currently limit their applications. Engineering can not only enhance range improve phage efficacy, but also confer new functions. This review first summarizes major engineering techniques including both chemical modification genetic engineering. Subsequent sections discuss applications engineered pathogen detection ablation through interdisciplinary approaches synthetic biology nanotechnology. We future directions persistent challenges in ongoing exploration control.
Language: Английский
Citations
8
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: May 15, 2024
Abstract Intracellular bacterial (ICB) infection is one of the most life‐threatening cases drug resistance, and photodynamic therapy (PDT) challenged by limited light penetration into tissues unspecific toxicity to host cells. Herein, theranostic nanoparticles (NPs) are developed facilitate on‐demand activation photosensitizers inside ICBs persistent PDT deep‐tissue ICB infections. Mechanoluminescent SrAl 2 O 4 :Eu 2+ persistence luminescent CaS:Eu sequentially deposited on mesoporous silica prepare mSC, followed encapsulation membranes with loaded nitroreductase (NTR)‐activatable methylene blue (nMB) obtain mSC‐nMB@BM NPs. The fluorescence quenching nMB mSC offers few cytotoxicities even under ultrasonication, membrane coatings mediate specific NP internalization ICB‐infected macrophages. Bacterial pore‐forming toxins trigger release from NPs, intrabacterial NTR rejuvenates probes for real‐time imaging Ultrasonication NPs continuously excites rejuvenated generate reactive oxidative species reduce viable 3.54 log magnitude folds. treatment mice exhibits full survival restores viscera functions without any pathological abnormality. Therefore, this concise design demonstrates capabilities membrane‐mediated internalization, toxin‐triggered NTR‐rejuvenation fluorescent probes, internal light‐illumination theranostics.
Language: Английский
Citations
4
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
The precise identification and efficient in situ eradication of intracellular bacteria can not only prevent the from persisting spreading within host but also accelerate healing infected wounds decrease caused complications. In this study, we designed a multifunctional quantum dot (QD) killer equipped with aggregation-induced emission (AIE) photosensitizers heterobivalent DNA sequences capability to specifically target, fluorescently image, efficiently eliminate bacteria. These QD killers undergo cell penetration following lipopolysaccharide receptor-mediated endocytosis then translocate cytosol for bacterial recognition labeling. Additionally, by leveraging robust photodynamic activity sensitizing killers, complete was realized reducing viability macrophages. cytocompatibility ensures safe treatment without harming normal cells. Notably, bacterial-infected vivo showed accelerated rates successful elimination administration. This work highlights potential eradicating hidden immune cells, providing promising strategy addressing infection-relevant diseases.
Language: Английский
Citations
0
Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Aggregation-induced emission (AIE) materials, due to their unique ability significantly enhance optical in aggregated states, have demonstrated vast potential immunology, particularly early disease diagnosis and immunotherapy. AIE materials can serve as highly efficient fluorescent probes for biomarker detection, providing critical insights diagnosis. Additionally, they act cancer vaccines, enhancing the effectiveness of immunotherapy through photodynamic therapy, photothermal or activation immune cells. This review highlights applications focusing on recent advancements diagnostics while also discussing challenges face directions future development.
Language: Английский
Citations
0
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 5, 2025
Photosensitizers (PSs) with aggregation-induced emission (AIE) properties have gained popularity for treating bacterial infections. However, most AIE PSs a poor water solubility and low selectivity, limiting their applications in biological systems. Herein, we report water-soluble bacteria-targeting PS that exhibits minimum cytotoxicity toward human cells without light irradiation. Acting as narrow-spectrum antibacterial agent irradiation, TPA-1 eradicates planktonic Staphylococcus aureus inhibits biofilm formation by targeting the S. membrane, inhibiting supercoiling activity of DNA gyrase, causing downregulation multiple essential proteins. Upon generates reactive oxygen species (ROS) cause membrane damage, resulting excellent antiplanktonic antibiofilm activities against Pseudomonas aeruginosa, significantly reducing number viable bacteria biofilms promoting wound healing vivo.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162429 - 162429
Published: April 1, 2025
Language: Английский
Citations
0