Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162683 - 162683
Published: April 1, 2025
Language: Английский
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 13, 2024
Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.
Language: Английский
Citations
18
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Language: Английский
Citations
5
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future
Language: Английский
Citations
3
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 1, 2025
Language: Английский
Citations
3
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4
Published: Jan. 31, 2025
Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(25), P. 16113 - 16125
Published: June 10, 2024
Urinary extracellular vesicles (uEVs) are regarded as highly promising liquid-biopsy biomarkers for the early diagnosis and prognosis of bladder cancer (BC). However, detection uEVs remains technically challenging owing to their huge heterogeneity ultralow abundance in real samples. We herein present a choline phosphate-grafted platinum nanozyme (Pt@CP) that acts universal EV probe construction high-throughput high-sensitivity immunoassay, which allowed multiplex profiling uEV protein markers BC detection. With Pt@CP-based immunoassays, three (MUC-1, CCDC25, GLUT1) were identified BC, by cases (n = 48), cystitis patients 27), healthy donors 24) discriminated with high clinical sensitivity specificity (area under curve 98.3%). For 9) after surgery, immunoassay could report postoperative residual tumor cannot be observed cystoscopy, is clinically significant assessing recurrence. This work provides generally detection, facilitating discovery use EV-based biomarkers.
Language: Английский
Citations
16
Small, Journal Year: 2024, Volume and Issue: unknown
Published: June 16, 2024
Abstract Nanozyme‐mediated chemodynamic therapy has emerged as a promising strategy due to its tumor specificity and controlled catalytic activity. However, the poor efficacy caused by low hydrogen peroxide (H 2 O ) levels in microenvironment (TME) poses challenges. Herein, an H self‐supplying nanozyme is constructed through loading peroxide‐like active platinum nanoparticles (Pt NPs) on zinc (ZnO (denoted ZnO @Pt). releases response acidic TME. Pt NPs catalyze hydroxyl radical generation from while reducing mitigation of oxidative stress glutathione, serving reactive oxygen (ROS) amplifier self‐cascade catalysis. In addition, Zn 2+ released interferes with cell energy supply metabolism, enabling ion interference synergize therapy. vitro studies demonstrate that @Pt induces cellular injury enhanced ROS release, downregulating ATP NAD + levels. vivo assessment anticancer effects showed could generate at sites induce apoptosis downregulate pathways associated glycolysis, resulting 89.7% reduction growth. This study presents TME‐responsive capable self‐supply therapy, providing paradigm for tumor‐specific design.
Language: Английский
Citations
13
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 18, 2024
Multiple enzyme-induced cascade catalysis has an indispensable role in the process of complex life activities, and is widely used to construct robust biosensors for analyzing various targets. The immobilized multi-enzyme system a novel biomimetic strategy that immobilizes enzymes with different functions stable carriers simulate synergistic multiple biological systems, which enables high stability efficiency enzymatic catalysis. Nanozymes, type nanomaterial intrinsic enzyme-like characteristics excellent stabilities, are also applied instead achieving better catalytic performance reaction stability. Due good stability, reusability, remarkably efficiency, multi-enzyme/nanozyme systems show distinct advantages promoting signal transduction amplification, thereby attracting vast research interest biosensing applications. This review focuses on progress recent years. construction approaches, factors affecting applications sensitive discussed detail. Further, their challenges outlooks future study provided.
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159464 - 159464
Published: Jan. 1, 2025
Language: Английский
Citations
1
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Organophosphorus pesticides (OPs) are widely used in agricultural production, posing a great threat to human health and the environment. Given that different OPs present toxicology toxicities, identifying individual pesticide residues becomes important for assessing food safety environmental implications. In this work, kinetics difference-driven analyte hydrolysis strategy is proposed first time validated identify p-nitrophenyl by developing an organophosphorus hydrolase-like nanozyme-coded sensor array. Ultrasmall bare CeO2 nanoparticles were synthesized employed as only sensing unit catalyze of multiple analytes. With catalytic preferences differences under identical reaction conditions, five common analogues (methyl-paraoxon, paraoxon, methyl-parathion, parathion, fenitrothion) offered discriminable colors. By coupling color fingerprints with pattern recognition, accurate identification their mixtures at variety concentrations ratios was verified laboratory practical scenarios. Attractively, apart from excellent performance convenient operation, hydrolytic presents strong resistance against redox substances often cause interference previous oxidoreductase-based arrays. Our study provides new paradigm discriminating specific precisely, showing promising applications multitarget analysis complex matrices.
Language: Английский
Citations
1