Cellular uptake of nanoparticles: journey inside the cell

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(14), P. 4218 - 4244

Published: Jan. 1, 2017

Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at cellular subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, structure a manner dictated largely by phenomena nano-bio interface. Recent advances chemical synthesis have yielded new nanoscale precisely defined biochemical features, emerging analytical techniques shed light on nuanced context-dependent within cells. In this review, we provide an objective comprehensive account of our current understanding uptake NPs underlying parameters controlling nano-cellular interactions, along available to follow track processes.

Language: Английский

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Compound Copper Chalcogenide Nanocrystals

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(9), P. 5865 - 6109

Published: April 10, 2017

This review captures the synthesis, assembly, properties, and applications of copper chalcogenide NCs, which have achieved significant research interest in last decade due to their compositional structural versatility. The outstanding functional properties these materials stems from relationship between band structure defect concentration, including charge carrier concentration electronic conductivity character, consequently affects optoelectronic, optical, plasmonic properties. This, combined with several metastable crystal phases stoichiometries low energy formation defects, makes reproducible synthesis materials, tunable parameters, remarkable. Further this, progress hierarchical assembly bridges link discrete collective Their ubiquitous application set has cross-cut conversion (photovoltaics, photocatalysis, thermoelectrics), storage (lithium-ion batteries, hydrogen generation), emissive (plasmonics, LEDs, biolabelling), sensors (electrochemical, biochemical), biomedical devices (magnetic resonance imaging, X-ray computer tomography), medical therapies (photochemothermal therapies, immunotherapy, radiotherapy, drug delivery). confluence advances NCs past potential significantly impact society, both economically environmentally.

Language: Английский

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(4), P. 1253 - 1321

Published: Jan. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Language: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Enhancing Both Biodegradability and Efficacy of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy

ACS Nano, Journal Year: 2018, Volume and Issue: 12(2), P. 1801 - 1810

Published: Jan. 31, 2018

Theranostic nanoagents are promising for precision medicine. However, biodegradable with the ability photoacoustic (PA) imaging guided photothermal therapy (PTT) rare. We herein report development of semiconducting polymer nanoparticles (SPNs) enhanced PA and PTT efficacy cancer therapy. The design capitalizes on enzymatically oxidizable nature vinylene bonds in conjunction chemistry to synthesize a (DPPV) transform it into water-soluble (SPNV). As compared its counterpart SPN (SPNT), presence within backbone also endows SPNV significantly mass absorption coefficient (1.3-fold) conversion (2.4-fold). such, provides signals maximum temperature higher than SPNT, allowing detection ablation tumors living mice more sensitive effective way. Our study thus reveals general molecular enhance biodegradability optically active while dramatically elevating their therapeutic capabilities.

Language: Английский

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Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy

ACS Nano, Journal Year: 2017, Volume and Issue: 11(4), P. 3990 - 4001

Published: April 10, 2017

Multifunctional nanomaterials with integrated diagnostic and therapeutic functions, combination therapy to enhance treatment efficacy, as well low toxicity have drawn tremendous attentions. Herein, we report a multifunctional theranostic agent based on peptide (LyP-1)-labeled ultrasmall semimetal nanoparticles of bismuth (Bi-LyP-1 NPs). Ultrasmall Bi NPs (3.6 nm) were facilely synthesized using oleylamine the reducing exhibited higher tumor accumulation after being conjugated tumor-homing LyP-1. The abilities absorb both ionizing radiation second near-infrared (NIR-II) window laser ensured that Bi-LyP-1 are capable dual-modal computed tomography/photoacoustic imaging efficient synergistic NIR-II photothermal/radiotherapy tumors. Moreover, could be rapidly cleared from mice through renal fecal clearance almost completely 30 days. Such cancer agents, coupled fast toxicity, shed light future use for biomedicine.

Language: Английский

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Recent progress on nanoparticle-based drug delivery systems for cancer therapy

Cancer Biology and Medicine, Journal Year: 2017, Volume and Issue: 14(3), P. 228 - 228

Published: Jan. 1, 2017

The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer have overcome several limitations conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size surface characteristics are key components nanotherapeutics, designed to passively or actively deliver anti-cancer drugs tumor cells. We provide an overview nanoparticle-based drug delivery methods therapies based on tumor-targeting strategies that been developed years.

Language: Английский

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Ultrafast Synthesis of Ultrasmall Poly(Vinylpyrrolidone)‐Protected Bismuth Nanodots as a Multifunctional Theranostic Agent for In Vivo Dual‐Modal CT/Photothermal‐Imaging‐Guided Photothermal Therapy

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 27(35)

Published: July 21, 2017

To elaborately fabricate real‐time monitoring and therapeutic function into a biocompatible nanoplatform is promising route in the cancer therapy field. However, package of diagnosis treatment single‐“element” nanoparticle remains challenge. Herein, ultrasmall poly(vinylpyrrolidone)‐protected bismuth nanodots (PVP‐Bi nanodots) are successfully synthesized through an ultrafacile strategy (1 min only under ambient conditions). The easy to synthesize both laboratory large scale using low‐cost ingredients. PVP‐Bi with size show good biocompatibility. Due high X‐ray attenuation ability Bi element, have prominent performance on computed tomography (CT) imaging. Moreover, exhibit photothermal conversion efficiency (η = 30%) because strong near‐infrared absorbance, which can serve as nanotheranostic agent for imaging therapy. subsequent PVP‐Bi‐nanodot‐mediated (PTT) result shows highly efficient ablation cells vitro vivo. be almost completely excreted from mice after 7 d. Blood biochemistry histology analysis suggests that negligible toxicity. All positive results reveal produced method platform dual‐modal CT/photothermal‐imaging‐guided PTT.

Language: Английский

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Biocompatible D–A Semiconducting Polymer Nanoparticle with Light‐Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 27(13)

Published: Feb. 15, 2017

The development of nanotheranostic agents that integrate diagnosis and therapy for effective personalized precision medicine has obtained tremendous attention in the past few decades. In this report, biocompatible electron donor-acceptor conjugated semiconducting polymer nanoparticles (PPor-PEG NPs) with light-harvesting unit is prepared developed highly photoacoustic imaging guided photothermal therapy. To best our knowledge, it first time concept exploited enhancing signal energy conversion polymer-based theranostic agent. Combined additional merits including pair to favor transfer fluorescence quenching effect after NP formation, efficiency PPor-PEG NPs determined be 62.3%, which highest value among reported NPs. Moreover, as-prepared not only exhibits a remarkable cell-killing ability but also achieves 100% tumor elimination, demonstrating its excellent therapeutic efficacy. Finally, water-dispersible show good biocompatibility biosafety, making them promising candidate future clinical applications cancer theranostics.

Language: Английский

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Top-down fabrication of shape-controlled, monodisperse nanoparticles for biomedical applications

Advanced Drug Delivery Reviews, Journal Year: 2018, Volume and Issue: 132, P. 169 - 187

Published: July 1, 2018

Language: Английский

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