Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(7), P. 2053 - 2108

Published: Sept. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Language: Английский

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Emerging two-dimensional monoelemental materials (Xenes) for biomedical applications

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 2891 - 2912

Published: Jan. 1, 2019

The emergence of novel two-dimensional (2D) monoelemental materials (Xenes) has shown remarkable potential for their applications in different fields technology, as well addressing new discoveries fundamental science. Xenes (e.g., borophene, silicene, germanene, stanene, phosphorene, arsenene, antimonene, bismuthene, and tellurene) are particular interest because they the most chemically tractable synthetic exploration. Owing to excellent physical, chemical, electronic optical properties, have been regarded promising agents biosensors, bioimaging, therapeutic delivery, theranostics, several other bio-applications. In this tutorial review, we summarize general properties including classification according bulk properties. modification methods also presented. Furthermore, representative Xene nanoplatforms various biomedical highlighted. Finally, research progress, challenges, perspectives future development biomedicines discussed.

Language: Английский

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Dual‐Peak Absorbing Semiconducting Copolymer Nanoparticles for First and Second Near‐Infrared Window Photothermal Therapy: A Comparative Study

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(14)

Published: Feb. 19, 2018

Near-infrared (NIR) light is widely used for noninvasive optical diagnosis and phototherapy. However, current research focuses on the first NIR window (NIR-I, 650-950 nm), while second (NIR-II, 1000-1700 nm) far less exploited. The development of organic photothermal nanoagent (SPNI-II ) with dual-peak absorption in both windows its utilization therapy (PTT) are reported herein. Such a comprises semiconducting copolymer two distinct segments that respectively identically absorb at 808 1064 nm. With conversion efficiency 43.4% nm generally higher than other inorganic nanomaterials, SPNI-II enables superior deep-tissue heating over their respective safety limits. Model cancer PTT tissue depth 5 mm validates enhanced antitumor effect when shifting laser irradiation from NIR-I to NIR-II window. good biodistribution facile synthesis also allow it be doped an dye fluorescence-imaging-guided through systemic administration. Thus, this study paves way new polymeric nanomaterials advance

Language: Английский

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Cancer Radiosensitizers

Trends in Pharmacological Sciences, Journal Year: 2017, Volume and Issue: 39(1), P. 24 - 48

Published: Dec. 8, 2017

Language: Английский

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Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation

ACS Nano, Journal Year: 2018, Volume and Issue: 12(11), P. 11000 - 11012

Published: Oct. 19, 2018

Therapeutic nanosystems which can be triggered by the distinctive tumor microenvironment possess great selectivity and safety to treat cancers via in situ transformation of nontoxic prodrugs into toxic therapeutic agents. Here, we constructed intelligent, magnetic targeting, microenvironment-responsive nanocatalysts that acquire oxidation therapy cancer specific reaction at site. The nanoparticle core iron carbide-glucose oxidase (Fe5C2-GOD) achieved physical absorption has a high enzyme payload, manganese dioxide (MnO2) nanoshell as an intelligent "gatekeeper" shields GOD from premature leaking until reaching tissue. Fe5C2-GOD@MnO2 maintained inactive normal cells upon systemic administration. On contrary, after endocytosis cells, acidic induced decomposition MnO2 Mn2+ O2, meanwhile releasing GOD. could serve resonance imaging (MRI) contrast agent for real-time monitoring treatment process. Then generated O2 released effectively exhaust glucose simultaneously generating plenty H2O2 may accelerate subsequent Fenton catalyzed Fe5C2 mildly microenvironments. Finally, demonstrated site-specific production highly hydroxyl radicals enhanced anticancer efficacy while minimizing toxicity mice.

Language: Английский

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(4), P. 1253 - 1321

Published: Jan. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Language: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Recent advances in nanomaterials for enhanced photothermal therapy of tumors

Nanoscale, Journal Year: 2018, Volume and Issue: 10(48), P. 22657 - 22672

Published: Jan. 1, 2018

Recent advances in nanomaterials for enhanced therapeutic efficacy of photothermal therapy tumor treatment were highlighted.

Language: Английский

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Fluorine-free preparation of titanium carbide MXene quantum dots with high near-infrared photothermal performances for cancer therapy

Nanoscale, Journal Year: 2017, Volume and Issue: 9(45), P. 17859 - 17864

Published: Jan. 1, 2017

Titanium carbide MXene quantum dots (QDs) were synthesized using an effective fluorine-free method as a biocompatible and highly efficient nanoagent for photothermal therapy (PTT) applications. In contrast to the traditional, hazardous time-consuming process of HF pretreatment, our is safe simple. More importantly, abundant Al oxoanions found be modified on QD surface by method, which endowed QDs with strong broad absorption in NIR region. As result, as-prepared exhibited extinction coefficient large 52.8 Lg-1 cm-1 at 808 nm conversion efficiency high 52.2%. Both values are among best reported so far. The achieved simultaneous photoacoustic (PA) imaging remarkable PTT effect tumors. Moreover, showed great biocompatibility without causing noticeable toxicity vitro vivo, indicating their potential clinical

Language: Английский

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Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(3)

Published: Aug. 29, 2018

Nano-radiosensitization has been a hot concept for the past ten years, and nanomaterial-mediated tumor radiosensitization method is mainly focused on increasing intracellular radiation deposition by high atomic number (high Z) nanomaterials, particularly gold (Au)-mediated enhancement. Recently, various new radiosensitive approaches have successively reported, such as catalyzing reactive oxygen species (ROS) generation, consuming reduced glutathione (GSH), overcoming hypoxia, synergistic radiotherapy ways. These strategies may open avenue enhancing radiotherapeutic effect avoiding its side effects. Nevertheless, reviews systematically summarizing these newly emerging methods their mechanisms are still rare. Therefore, general of comprehensively summarized, aiming at introducing methods. The divided into three parts. First, account intrinsic properties nanoradiosensitizers highlighted. Then, developed based multifunctional nanomaterials efficacy emphasized. Third, radioprotection ratio discussed. Importantly, clinical translation also covered. Finally, further challenges outlooks in this field

Language: Английский

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