Small,
Journal Year:
2021,
Volume and Issue:
17(51)
Published: Oct. 13, 2021
Abstract
Pathogenic
infections
seriously
threaten
public
health
and
have
been
considered
as
one
of
the
most
critical
challenges
in
clinical
therapy.
Construction
a
safe
efficient
photothermal
antibacterial
platform
is
promising
strategy
for
treatment
bacterial
infections.
Considering
that
high
temperature
does
harm
to
normal
tissues
cells,
herein,
bacteria‐triggered
multifunctional
hydrogel
constructed
low‐temperature
sterilization
with
efficiency
by
integrating
localized
chemodynamic
therapy
(L‐CDT).
The
incorporating
copper
sulfide
nanoparticles
(CuS
NPs
)
profile
into
network
hyaluronic
acid
(HA)
Fe
3+
‐EDTA
complexes,
named
CHFH
‐HA‐Fe
hydrogel).
Bacteria
can
be
accumulated
on
surface
CHFH,
which
secretes
hyaluronidase
decompose
HA
release
.
reduced
2+
microenvironment
bacteria
trigger
Fenton
reaction.
generated
hydroxyl
radicals
result
based
L‐CDT
within
short
range.
By
property
CuS
,
(LT‐PTT)
realized,
improves
while
minimizes
damage
tissues.
further
used
prepare
Band
aid
effectively
promotes
Staphylococcus
aureus
‐infected
wound
healing
process
vivo,
confirming
great
potential
application.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(11)
Published: Feb. 5, 2020
Abstract
Photodynamic
therapy
(PDT)
efficacy
has
been
severely
limited
by
oxygen
(O
2
)
deficiency
in
tumors
and
the
electron–hole
separation
inefficiency
photosensitizers,
especially
long‐range
diffusion
of
O
toward
photosensitizers
during
PDT
process.
Herein,
novel
bismuth
sulfide
(Bi
S
3
)@bismuth
(Bi)
Z‐scheme
heterostructured
nanorods
(NRs)
are
designed
to
realize
spatiotemporally
synchronous
self‐supply
production
reactive
species
for
hypoxic
tumor
therapy.
Both
narrow‐bandgap
Bi
components
can
be
excited
a
near‐infrared
laser
generate
abundant
electrons
holes.
The
heterostructure
endows
@Bi
NRs
with
an
efficient
ability
potent
redox
potentials,
where
hole
on
valence
band
react
water
supply
electron
conduction
produce
species.
overcome
major
obstacles
conventional
process
exhibit
promising
phototherapeutic
effect,
supplying
new
strategy
elimination.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(21), P. 12037 - 12069
Published: Jan. 1, 2021
Bismuth-based
compounds
have
been
used
extensively
as
medicines
for
the
treatment
of
gastrointestinal
disorders
and
H.
pylori
infections.
Bismuth
Bi-based
nanomaterials
show
promise
emerging
infectious
diseases,
cancer
(
e.g.
213
Bi)
also
imaging.
ACS Nano,
Journal Year:
2019,
Volume and Issue:
13(6), P. 7345 - 7354
Published: June 12, 2019
Liver
tumor
is
one
of
the
most
lethal
cancers
due
to
its
low
ratio
surgical
resection,
high
recurrence
rate,
and
invasiveness.
Photothermal
therapy
(PTT)
possesses
many
advantages
for
cancer
because
noninvasive
nature.
However,
PTT
conducted
in
first
near-infrared
(NIR-I)
window,
so
second
(NIR-II)
photosensitizers
with
higher
penetrating
ability
clinical
prospects
are
seriously
desirable.
Herein,
a
semiconducting
polymer
optimized
absorption
NIR-I
NIR-II
regions
obtained
by
ternary
copolymerization
methodology.
The
prepared
nanoparticle
(NP)
from
used
treatment
orthotopic
liver
upon
laser
irradiation.
Compared
an
808
nm
laser,
1064
leads
more
effective
inhibition
toward
same
conditions.
These
results
thus
demonstrate
that
polymeric
NPs
may
inspire
another
aspect
highly
efficient
various
cancers.
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 1083 - 1102
Published: Feb. 1, 2021
Abstract:
Radiotherapy
(RT)
is
a
cancer
treatment
that
uses
high
doses
of
radiation
to
kill
cells
and
shrink
tumors.
Although
great
success
has
been
achieved
on
radiotherapy,
there
still
an
intractable
challenge
enhance
damage
tumor
tissue
reduce
side
effects
healthy
tissue.
Radiosensitizers
are
chemicals
or
pharmaceutical
agents
can
the
killing
effect
by
accelerating
DNA
producing
free
radicals
indirectly.
In
most
cases,
radiosensitizers
have
less
normal
tissues.
recent
years,
several
strategies
exploited
develop
highly
effective
low
toxicity.
this
review,
we
first
summarized
applications
including
small
molecules,
macromolecules,
nanomaterials,
especially
those
used
in
clinical
trials.
Second,
development
states
possible
mechanisms
improve
sensibility
reviewed.
Third,
challenges
prospects
for
translation
oncotherapy
presented.
Keywords:
radiosensitizers,
therapeutics,
nanomedicine,
mechanism
Corrigendum
paper
published
Small,
Journal Year:
2021,
Volume and Issue:
17(51)
Published: Oct. 13, 2021
Abstract
Pathogenic
infections
seriously
threaten
public
health
and
have
been
considered
as
one
of
the
most
critical
challenges
in
clinical
therapy.
Construction
a
safe
efficient
photothermal
antibacterial
platform
is
promising
strategy
for
treatment
bacterial
infections.
Considering
that
high
temperature
does
harm
to
normal
tissues
cells,
herein,
bacteria‐triggered
multifunctional
hydrogel
constructed
low‐temperature
sterilization
with
efficiency
by
integrating
localized
chemodynamic
therapy
(L‐CDT).
The
incorporating
copper
sulfide
nanoparticles
(CuS
NPs
)
profile
into
network
hyaluronic
acid
(HA)
Fe
3+
‐EDTA
complexes,
named
CHFH
‐HA‐Fe
hydrogel).
Bacteria
can
be
accumulated
on
surface
CHFH,
which
secretes
hyaluronidase
decompose
HA
release
.
reduced
2+
microenvironment
bacteria
trigger
Fenton
reaction.
generated
hydroxyl
radicals
result
based
L‐CDT
within
short
range.
By
property
CuS
,
(LT‐PTT)
realized,
improves
while
minimizes
damage
tissues.
further
used
prepare
Band
aid
effectively
promotes
Staphylococcus
aureus
‐infected
wound
healing
process
vivo,
confirming
great
potential
application.
