Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(48)
Published: Sept. 27, 2021
Photodynamic
therapy
(PDT)
has
aroused
great
research
interest
in
recent
years
owing
to
its
high
spatiotemporal
selectivity,
minimal
invasiveness,
and
low
systemic
toxicity.
However,
due
the
hypoxic
nature
characteristic
of
many
solid
tumors,
PDT
is
frequently
limited
therapeutic
effect.
Moreover,
consumption
O2
during
may
further
aggravate
tumor
condition,
which
promotes
proliferation,
metastasis,
invasion
resulting
poor
prognosis
treatment.
Therefore,
numerous
efforts
have
been
made
increase
content
with
goal
enhancing
efficacy.
Herein,
these
strategies
developed
past
decade
are
comprehensively
reviewed
alleviate
hypoxia,
including
1)
delivering
exogenous
directly,
2)
generating
situ,
3)
reducing
cellular
by
inhibiting
respiration,
4)
regulating
TME,
(e.g.,
normalizing
vasculature
or
disrupting
extracellular
matrix),
5)
hypoxia-inducible
factor
1
(HIF-1)
signaling
pathway
relieve
hypoxia.
Additionally,
-independent
Type-I
also
discussed
as
an
alternative
strategy.
By
reviewing
progress,
it
hoped
that
this
review
will
provide
innovative
perspectives
new
nanomaterials
designed
combat
hypoxia
avoid
associated
limitation
PDT.
Small,
Journal Year:
2021,
Volume and Issue:
17(31)
Published: May 26, 2021
Photodynamic
therapy
(PDT)
has
shown
great
potential
for
tumor
treatment
with
merits
of
non-invasiveness,
high
selectivity,
and
minimal
side
effects.
However,
conventional
type
II
PDT
relying
on
1
O2
presents
poor
therapeutic
efficacy
hypoxic
tumors
due
to
the
oxygen-dependent
manner.
Alternatively,
emerging
researches
have
demonstrated
that
I
exhibits
superiority
over
in
owing
its
diminished
oxygen-dependence.
In
this
review,
state-of-the-art
studies
concerning
recent
progress
photosensitizers
are
scrutinized,
emphasizing
strategies
construct
highly
effective
photosensitizers.
As
foundation,
basic
principles
presented,
up-to-date
summarized
classified
based
their
attributes.
Then,
a
literature
review
representative
(including
nanomaterials
small
molecules)
is
presented
impetus
delineate
novel
designs,
action
mechanisms,
as
well
anticancer
applications.
Finally,
remaining
challenges
development
directions
outlined,
highlighting
key
scientific
issues
toward
clinical
translations.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(32)
Published: June 10, 2021
Abstract
Non‐invasive
cancer
photothermal
therapy
(PTT)
is
a
promising
replacement
for
traditional
treatments.
The
second
near‐infrared
region
induced
PTT
(NIR‐II
PTT,
1000–1500
nm)
with
less
energy
dissipation
has
been
developed
deeper‐seated
tumor
treatment
in
recent
years
compared
the
first
light
(750–1000
nm).
In
addition,
use
of
emerging
inorganic
2D
nanomaterials
as
agents
(PTAs)
further
enhanced
efficiency
due
to
their
intrinsic
properties.
NIR‐II
stimulated
becoming
hot
topic
both
academic
and
clinical
fields.
This
review
summarizes
categories,
structures,
conversion
properties
time.
synergistic
strategies
responsive
combined
other
approaches
including
chemotherapy,
chemodynamic
therapy,
photodynamic
radiotherapy
are
summarized.
future
challenges
perspectives
on
these
systems
construction
discussed.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(52)
Published: Oct. 9, 2021
Abstract
Catalytic
cancer
therapy
based
on
nanozymes
has
recently
attracted
much
interest.
However,
the
types
of
current
are
limited
and
their
efficiency
is
usually
compromised
not
sustainable
in
tumor
microenvironment
(TME).
Therefore,
combination
involving
additional
therapeutics
often
necessary
resulting
complication
may
jeopardize
practical
feasibility.
Herein,
an
unprecedented
“all‐in‐one”
Fe
3
O
4
/Ag/Bi
2
MoO
6
nanoparticle
(FAB
NP)
rationally
devised
to
achieve
synergistic
chemodynamic,
photodynamic,
photothermal
with
guidance
by
magnetic
resonance,
photoacoustic,
imaging.
Based
its
manifold
nanozyme
activities
(mimicking
peroxidase,
catalase,
superoxide
dismutase,
glutathione
oxidase)
photodynamic
property,
cascaded
nanocatalytic
reactions
enabled
sustained
TME
for
outstanding
therapeutic
outcomes.
The
working
mechanisms
underlying
intraparticulate
interactions,
sustainability,
self‐replenishment
arising
from
coupling
between
carefully
revealed,
providing
new
insights
into
design
novel
high
efficiency,
good
specificity,
low
side
effects.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 13, 2022
Abstract
Although
two-dimensional
(2D)
layered
double
hydroxides
(LDHs)
have
been
widely
used
as
efficient
nanoagents
for
biological
diagnosis
and
treatment,
they
found
to
be
inert
photosensitizers
(PSs)
photodynamic
therapy
(PDT).
Herein,
we
report
the
defect
engineering
of
ultrathin
2D
CoMo-LDH
NiMo-LDH
nanosheets
highly
active
inorganic
PSs
PDT
in
third
near-infrared
(NIR-III)
window.
Hydrothermal-synthesized
are
etched
via
a
simple
acid
treatment
obtain
defect-rich
nanosheets.
Importantly,
exhibit
much
higher
activity
(~97
times)
generation
reactive
oxygen
species
than
that
pristine
under
NIR-III
1567
nm
laser
irradiation.
Therefore,
after
modification
with
polyethylene
glycol,
can
an
PS
efficiently
induce
cancer
cells
apoptosis
vitro
eradicate
tumors
vivo
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(36)
Published: July 23, 2021
The
development
and
optimization
of
sonosensitizers
for
elevating
intratumoral
reactive
oxygen
species
(ROS)
are
definitely
appealing
in
current
sonodynamic
therapy
(SDT).
Given
this,
branched
vanadium
tetrasulfide
(VS4
)
nanodendrites
with
a
narrower
bandgap
(compared
the
most
extensively
explored
sonosensitizers)
presented
as
new
source
sonosensitizer,
which
allows
more
effortless
separation
sono-triggered
electron-hole
pairs
ROS
generation.
Specifically,
platinum
(Pt)
nanoparticles
endogenous
high
levels
glutathione
(GSH)
rationally
engineered
to
further
optimize
its
sono-sensitized
performance.
As
cocatalyst,
Pt
is
conducive
trapping
electrons,
whereas
GSH,
natural
hole-scavenger,
tends
capture
holes.
Compared
pristine
VS4
GSH-Pt-VS4
nanocomposite
can
greatly
prolong
lifetime
charge
confer
highly
efficacious
production
activity.
Furthermore,
such
nanoplatforms
capable
reshaping
tumor
microenvironments
realize
overproduction,
contributed
by
overcoming
hypoxia
improve
SDT-triggered
singlet
production,
catalyzing
endogenic
hydrogen
peroxide
into
destructive
hydroxyl
radicals
chemodynamic
therapy,
depleting
GSH
amplify
oxidative
stress.
All
these
combined
effects
result
significantly
efficient
suppression
outcome.
This
study
enriches
sonosensitizer
research
proves
that
be
optimized
engineering
strategy.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 2, 2022
Effective
photosensitizers
are
of
particular
importance
for
the
widespread
clinical
utilization
phototherapy.
However,
conventional
usually
plagued
by
short-wavelength
absorption,
inadequate
photostability,
low
reactive
oxygen
species
(ROS)
quantum
yields,
and
aggregation-caused
ROS
quenching.
Here,
we
report
a
near-infrared
(NIR)-supramolecular
photosensitizer
(RuDA)
via
self-assembly
an
organometallic
Ru(II)-arene
complex
in
aqueous
solution.
RuDA
can
generate
singlet
(1O2)
only
aggregate
state,
showing
distinct
aggregation-induced
1O2
generation
behavior
due
to
greatly
increased
singlet-triplet
intersystem
crossing
process.
Upon
808
nm
laser
irradiation,
with
excellent
photostability
displays
efficient
heat
yield
16.4%
(FDA-approved
indocyanine
green:
ΦΔ
=
0.2%)
together
high
photothermal
conversion
efficiency
24.2%
(commercial
gold
nanorods:
21.0%,
nanoshells:
13.0%).
In
addition,
RuDA-NPs
good
biocompatibility
be
preferably
accumulated
at
tumor
sites,
inducing
significant
regression
95.2%
volume
reduction
vivo
during
photodynamic
therapy.
This
aggregation
enhanced
therapy
provides
strategy
design
promising
photophysical
photochemical
characteristics.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Nov. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
