Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(14)

Published: Dec. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Language: Английский

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Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Small, Journal Year: 2021, Volume and Issue: 17(6)

Published: Jan. 15, 2021

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis treatment. Although many exogenous contrast agents been developed for PA PTT, the design guidelines to amplify their performances remain challenging are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π-electron delocalized backbones can be designed PTT performance, because clear structure-property relation versatility modifying molecular structures tune photophysical properties. This review summarizes recent advances photoacoustic applications semiconducting a focus on signal amplification second near-infrared (NIR-II, 1000-1700 nm) construction. The strategies such as screening, fluorescence quenching, accelerated heat dissipation, size-dependent dissipation first discussed brightness SPNs vivo PA. approaches shifting absorption NIR-II then introduced so improve tissue penetration depth therapy. At last, current challenges perspectives field discussed.

Language: Английский

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Achieving Efficient NIR‐II Type‐I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Dec. 22, 2021

Second near-infrared (NIR-II) window type-I photosensitizers have intrinsic advantages in photodynamic/photothermal therapy (PDT/PTT) of some malignant tumors with deep infiltration, large size, complicated location, and low possibility surgery/radiotherapy. Herein, three chalcogen-element-based donor-acceptor-type semiconducting polymers (poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(thiophene)] (PTS), poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(selenophene)] (PTSe), poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4'H)-dione)-alt-2,5-(tellurophene)] (PTTe)) are synthesized fully characterized, demonstrating strong absorption the NIR-II region. Upon adjusting chalcogen elements, intramolecular charge-transfer characteristics heavy-atom effect tuned to enhance intersystem crossing rate, improving photodynamic effect. Moreover, energy levels Gibbs free energies facilitate process. As a result, PTTe nanoparticles (NPs) produce superoxide anion radicals (O2•- ) more efficiently demonstrate higher photothermal conversion efficiency than PTS PTSe NPs upon (1064 nm) laser irradiation, exhibiting unprecedented PDT/PTT performance vitro vivo. This work provides ideas for achieving high-performance hypoxic oncotherapy.

Language: Английский

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Janus Nanoparticles: From Fabrication to (Bio)Applications

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 6147 - 6191

Published: March 19, 2021

Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies JNPs have been significant interest due their interesting characteristics stemming from asymmetric structures, which can integrate different functional properties and perform synergetic functions simultaneously. Herein, we present recent progress particles, comprehensively detailing fabrication strategies applications. First, classification is divided three blocks, consisting polymeric composites, inorganic hybrid polymeric/inorganic composites. Then, are alternately summarized, examining self-assembly strategy, phase separation seed-mediated polymerization, microfluidic preparation nucleation growth methods, masking methods. Finally, various intriguing applications presented, including solid surfactants agents, micro/nanomotors, biomedical such as biosensing, controlled drug delivery, bioimaging, cancer therapy, combined theranostics. Furthermore, challenges future works in this field provided.

Language: Английский

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Cell primitive-based biomimetic functional materials for enhanced cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 945 - 985

Published: Nov. 23, 2020

Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. primitives are characterized by distinctive biological functions, such long-term circulation, tumor specific targeting, immune modulation etc. Moreover, synthetic nanomaterials featuring unique physical/chemical properties been widely used effective drug delivery vehicles or anticancer to treat cancer. The combination these two kinds will catalyze generation innovative biomaterials with multiple high biocompatibility negligible immunogenicity precise In this review, we summarize most recent advances in development cell Different primitives, including bacteria, phages, cells, membranes, other bioactive introduced their strategies combining materials, especially nanoparticulate systems, construction function-enhanced also summarized. Furthermore, foreseeable challenges future perspectives included research direction field.

Language: Английский

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Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep‐Seated Tumors

Small, Journal Year: 2021, Volume and Issue: 17(21)

Published: April 22, 2021

Small molecular dye that simultaneously exerts dual PDT/PTT effects as well florescence imaging triggered by a single NIR-II light has never been reported to date. Apart from the huge challenge in pushing absorption profile into region, fine-tuning dyes' excited state via rational structure design meet all three functions, especially oxygen photosensitization, remains most prominent throttle. Herein, five novel dyes (BHs) are productively developed strategically conjugating dyad innovative xanthonium with sequentially extended polymethine bridges, enabling intense 890 1206 nm, significantly 400 nm longer than conventional cyanine same polymethines. More importantly, owning high resonance and favorable energy population induced greater rigidity ring-fused amino, BH 1024 exhibits best singlet generation capability, moderate photothermal heating, considerable fluorescence under 1064 laser irradiation. Furthermore, is encapsulated folate-functionalized polymer, which demonstrated synergetic effect vitro vivo, eventually achieving solid tumors elimination guide. As far it known, this first time small for PDT or explored designed.

Language: Английский

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Recent advances in the development of near-infrared organic photothermal agents

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 417, P. 128844 - 128844

Published: Feb. 7, 2021

Language: Английский

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Recent Progress on NIR-II Photothermal Therapy

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: July 29, 2021

Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials near-infrared region (NIR-I, 750-900 nm) attracts extensive attention recent years because good biological penetration NIR light. However, depth still not enough for solid tumors due to high tissue scattering. light second (NIR-II, 1000-1700 allows deeper penetration, higher upper limit radiation and greater tolerance than that NIR-I, it shows application potential conversion. This review summarizes properties Au nanomaterials, two-dimensional materials, metal oxide sulfides polymers NIR-II their prospects It will arouse interest scientists as well nanomedicine.

Language: Английский

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