Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Theranostics, Journal Year: 2022, Volume and Issue: 12(7), P. 3372 - 3406

Published: Jan. 1, 2022

Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a global burden affecting world economy. severely impact patients' quality life have influenced their physical mental state. Treatment these disorders with conventional methods shows lack therapeutic efficacy, long treatment duration, recurrence condition, systemic side effects due to improper drug delivery. However, pitfalls can be overcome applications advanced nanocarrier- microneedle (MN)-based transdermal delivery strategies that provide efficient site-specific at target site. These more effective than other administration routes by avoiding first-pass metabolism, enhancing concentration in local lesions, reducing toxicity. Compared traditional methods, or MN-based systems painless, noninvasive, minimum-invasive require no expensive equipment. More importantly, they introduce functions, including increased penetration efficiency, controlled release rates, enhanced targeting abilities, theranostic functions. Here, emergence versatile for various drugs is reviewed, focusing on design principles, advantages, considerations treating diverse psoriasis, dermatitis, melanoma, diseases. Moreover, prospects challenges dermatological summarized.

Language: Английский

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Smart drug delivery systems for precise cancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(11), P. 4098 - 4121

Published: Aug. 22, 2022

Language: Английский

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Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

ACS Omega, Journal Year: 2022, Volume and Issue: 8(1), P. 74 - 86

Published: Dec. 20, 2022

Nanocarriers have the utmost significance for advancements in drug delivery and nanomedicine technology. They are classified as polymer-based nanocarriers, lipid-based viral nanoparticles, or inorganic depending on their constituent parts. Lipid-based nanocarrier systems gained tremendous attention over years because of noteworthy properties like high drug-loading capacity, lower toxicity, better bioavailability biocompatibility, stability gastrointestinal tract, controlled release, simpler scale-up, validation process. still some disadvantages poor penetration, limited encapsulation, targeting. These can be overcome by surface modification. Surface-modified nanocarriers result enhanced penetration efficiency, targeted medication delivery. In this review, authors summarize numerous functionalization through various modifiers such polymers, ligands, surfactants, fatty acids. Recent examples newly developing surface-modified from available literature, along with applications, been compiled work.

Language: Английский

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3D‐Printed Functional Hydrogel by DNA‐Induced Biomineralization for Accelerated Diabetic Wound Healing

Advanced Science, Journal Year: 2023, Volume and Issue: 10(17)

Published: April 19, 2023

Chronic wounds in diabetic patients are challenging because their prolonged inflammation makes healing difficult, thus burdening patients, society, and health care systems. Customized dressing materials needed to effectively treat such that vary shape depth. The continuous development of 3D-printing technology along with artificial intelligence has increased the precision, versatility, compatibility various materials, providing considerable potential meet abovementioned needs. Herein, functional inks comprising DNA from salmon sperm DNA-induced biosilica inspired by marine sponges, developed for machine learning-based wound dressings. biomineralized silica incorporated into hydrogel a fast, facile manner. 3D-printed generates provided appropriate porosity, characterized effective exudate blood absorption at sites, mechanical tunability indicated good fidelity printability during optimized 3D printing. Moreover, act as nanotherapeutics, enhancing biological activity dressings terms reactive oxygen species scavenging, angiogenesis, anti-inflammation activity, thereby accelerating acute healing. These bioinspired hydrogels produce using biomineralization strategy an excellent platform clinical applications chronic repair.

Language: Английский

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Functional nano-systems for transdermal drug delivery and skin therapy

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(6), P. 1527 - 1558

Published: Jan. 1, 2023

Functional nano-systems have been applied as a promising strategy for transdermal drug delivery and skin therapy.

Language: Английский

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Transferosomes as a transdermal drug delivery system: Dermal kinetics and recent developments

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2023, Volume and Issue: 16(1)

Published: Aug. 1, 2023

Abstract The development of innovative approaches to deliver medications has been growing now for the last few decades and generates a interest in dermatopharmaceutical field. Transdermal drug delivery particular, remains an attractive alternative route many therapeutics. However, due limitations posed by barrier properties stratum corneum, pharmaceutical dosage forms challenge. Most successful therapies using transdermal have ones containing smaller lipophilic molecules with molecular weights hundred Daltons. To overcome these size lipophilicity drugs, transferosomes emerged as tool variety therapeutics including hydrophilic actives, larger molecules, peptides, proteins, nucleic acids. Transferosomes exhibit flexible structure higher surface hydrophilicity which both play critical role transport drugs other solutes hydration gradients driving force into across skin. This results enhanced overall permeation well controlled release skin layers. Additionally, physical–chemical provide increased stability preventing degradation actives oxidation, light, temperature. Here, we present history from solid lipid nanoparticles liposomes, their properties, dermal kinetics, recent advances marketed forms. article is categorized under: Biology‐Inspired Nanomaterials > Lipid‐Based Structures Therapeutic Approaches Drug Discovery Emerging Technologies

Language: Английский

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Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4417 - 4441

Published: May 26, 2023

Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use limited by suboptimal bioavailability, serious adverse effects, nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks improve patient compliance, making them promising option (RA). Of course, TDDSs also face unique challenges, as physiological barrier skin makes somewhat limited. To overcome this maximize efficiency, evolved in terms principle facilitation technology, different generations derived, which significantly improved efficiency even achieved individualized controlled delivery. review, we summarize systems, corresponding strategies, applications RA.

Language: Английский

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Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 23, 2020

Abstract Recent interest in the control of bone metabolism has focused on a specialized subset CD31 hi endomucin vessels, which are reported to couple angiogenesis with osteogenesis. However, underlying mechanisms that link these processes together remain largely undefined. Here we show zinc-finger transcription factor ZEB1 is predominantly expressed endothelium human and mouse bone. Endothelial cell-specific deletion mice impairs vessel formation bone, resulting reduced Mechanistically, reduces histone acetylation Dll 4 Notch1 promoters, thereby epigenetically suppressing Notch signaling, critical pathway controls expression skeletal declines osteoporotic humans. Administration Zeb1 -packaged liposomes restores impaired activity endothelium, promoting angiogenesis-dependent osteogenesis ameliorating loss. Pharmacological reversal low ZEB1/Notch signaling may exert therapeutic benefit patients by formation.

Language: Английский

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Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs

Journal of Controlled Release, Journal Year: 2019, Volume and Issue: 309, P. 106 - 124

Published: July 16, 2019

Language: Английский

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Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis

ACS Nano, Journal Year: 2020, Volume and Issue: 14(4), P. 4523 - 4535

Published: March 19, 2020

We herein developed an iontophoretic transdermal drug delivery system for the effective of electrically mobile nanocarriers (DNs). Our consists a portable and disposable reverse electrodialysis (RED) battery that generates electric power iontophoresis through ionic exchange. In addition, in order to provide reservoir RED-driven system, electroconductive hydrogel composed polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP facilitated electron transfer from RED accelerated mobility DNs released hydrogel. this study, we showed fluconazole- or rosiglitazone-loaded could be functionalized with charge-inducing agents, charge modification resulted transport via repulsive iontophoresis. topical application antiobese condition displaying decreased bodyweight, reduced glucose level, increased conversion white adipose tissues brown vivo. Consequently, highlight platform would extensively utilized delivering diverse therapeutic agents noninvasive way.

Language: Английский

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