One‐Dimensional Fe₂P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(8), P. 2407 - 2412

Published: Jan. 2, 2019

Abstract The stringent reaction conditions for an effective Fenton (pH range of 3–4) hinders its application in cancer therapy. Therefore, how to improve the efficiency a tumor site has been main obstacle chemodynamic therapy (CDT). Herein, we report biocompatible one‐dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)‐ and photothermal (PT)‐enhanced properties excellent conversion (56.6 %) NIR II window, showing synergistic therapeutic properties. Additionally, high traverse relaxivity (277.79 m −1 s ) FP NRs means they are photoacoustic imaging (PAI) magnetic resonance (MRI) agents. This is first on exploiting response metallic phosphides laser (1064 nm) CDT effect PA/MR imaging.

Language: Английский

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Nanocatalytic Tumor Therapy by Single-Atom Catalysts

ACS Nano, Journal Year: 2019, Volume and Issue: unknown

Published: Feb. 12, 2019

Initiating localized catalytic chemical reactions in tumor microenvironment (TME) can achieve appealing tumor-therapeutic efficacy concurrently with high specificity and desirable biosafety, which is mainly dependent on the performance of biomedical nanocatalysts. This report demonstrates that PEGylated single-atom Fe-containing nanocatalysts (PSAF NCs) could effectively trigger situ tumor-specific Fenton reaction to generate abundant toxic hydroxyl radicals (•OH) selectively under acidic TME. Based density functional theory, it has been theoretically uncovered specifically catalyze heterogeneous via a proton-mediated H2O2-homolytic pathway. These generated not only lead apoptotic cell death malignant tumors, but also induce accumulation lipid peroxides, causing ferroptosis, synergistically an impressive suppression outcome. In meantime, favorable biodegradability biocompatibility PSAF NCs guarantee their biosafety both vivo vitro.

Language: Английский

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Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

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Self‐Supply of O₂ and H₂O₂ by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy

Advanced Science, Journal Year: 2019, Volume and Issue: 6(24)

Published: Oct. 24, 2019

Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H

Language: Английский

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Single‐Atom Catalysts in Catalytic Biomedicine

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(8)

Published: Jan. 13, 2020

The intrinsic deficiencies of nanoparticle-initiated catalysis for biomedical applications promote the fast development alternative versatile theranostic modalities. catalytic performance and selectivity are critical issues that challenging to be augmented optimized in biological conditions. Single-atom catalysts (SACs) featuring atomically dispersed single metal atoms have emerged as one most explored biomedicine recently due their preeminent activity superior distinct from nanosized counterparts. Herein, an overview pivotal significance SACs some underlying need addressed is provided, with a specific focus on applications. Their fabrication strategies, surface engineering, structural characterizations discussed briefly. In particular, triggering representative reactions providing fundamentals use discussed. A sequence paradigms summarized successful construction varied (e.g., cancer treatment, wound disinfection, biosensing, oxidative-stress cytoprotection) emphasis uncovering mechanisms understanding structure–performance relationships. Finally, opportunities challenges faced future SACs-triggered outlooked.

Language: Английский

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Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

Nano Today, Journal Year: 2020, Volume and Issue: 32, P. 100851 - 100851

Published: Feb. 21, 2020

Language: Английский

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Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)

Published: Dec. 20, 2020

Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development

Language: Английский

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Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy

Biomaterials, Journal Year: 2020, Volume and Issue: 252, P. 120093 - 120093

Published: May 10, 2020

Language: Английский

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Tumor-Targeted Cascade Nanoreactor Based on Metal–Organic Frameworks for Synergistic Ferroptosis–Starvation Anticancer Therapy

ACS Nano, Journal Year: 2020, Volume and Issue: 14(9), P. 11017 - 11028

Published: Aug. 13, 2020

Although ferroptosis therapy has been proven to be a promising strategy for cancer treatment, its efficacy still might limited by insufficient H2O2 supply in tumor tissue. Herein, we designed cell membrane-cloaked cascade nanoreactor based on ferric metal–organic frameworks (MOF) and glucose oxidase (GOx) decoration synergistic ferroptosis–starvation anticancer therapy. The GOx can catalyze generate sufficient therapy, the consumption caused utilized as another attractive treatment called starvation When reached sites, high concentration of GSH reduced Fe3+ trigger structure collapse MOF release Fe2+ catalyzed oxidation H2O2. Then Fenton reaction happened between produce hydroxyl radicals (•OH) promoted With these reactions, was realized. Furthermore, membrane endows homologous targeting immune escaping ability, which facilitated accumulate into site with efficiency. exhibits efficiency suppression situ consumed produced compounds, promote development precise cooperative spatiotemporal controllability.

Language: Английский

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Persistent Regulation of Tumor Microenvironment via Circulating Catalysis of MnFe₂O₄@Metal–Organic Frameworks for Enhanced Photodynamic Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(25)

Published: April 22, 2019

Abstract Reactive oxygen species (ROS)‐based cancer therapy, such as photodynamic therapy (PDT), is subject to the hypoxia and overexpressed glutathione (GSH) found in tumor microenvironment (TME). Herein, a novel strategy reported continuously simultaneously regulate reducibility order achieve desired therapeutic effect. To accomplish this, biocompatible nanoplatform (MnFe 2 O 4 @metal–organic framework (MOF)) developed by integrating coating of porphyrin‐based MOF photosensitizer manganese ferrite nanoparticle ) nanoenzyme. The synthetic MnFe @MOF exhibits both catalase‐like peroxidase‐like activities. Once internalized tumor, can catalyze H produce overcome cyclic Fenton reaction. Meanwhile, combined with reaction, able persistently consume GSH presence , which decreases depletion ROS upon laser irradiation during PDT achieves better efficacy vitro vivo. Moreover, integrates treatment modality magnetic resonance imaging, along persistent regulation TME, promote more precise effective for future clinical application.

Language: Английский

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