Metal–Organic Frameworks for Biomedical Applications

Small, Journal Year: 2020, Volume and Issue: 16(10)

Published: Feb. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Language: Английский

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Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(40)

Published: Aug. 28, 2020

Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can phagocytose tumor cells, while anti-inflammatory M2 such as tumor-associated (TAMs) promote growth invasion. Modulating the immune microenvironment through engineering is efficacious therapy. target cancerous cells and, therefore, be used drug carriers for Herein, strategies to engineer immunotherapy, inhibition of macrophage recruitment, depletion TAMs, reprograming blocking CD47-SIRPα pathway, are discussed. Further, recent advances delivery using macrophages, macrophage-derived exosomes, macrophage-membrane-coated nanoparticles elaborated. Overall, there still significant room macrophage-mediated modulation delivery, which will further enhance current therapies against various malignant solid tumors, including drug-resistant tumors metastatic tumors.

Language: Английский

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Metal-organic frameworks for stimuli-responsive drug delivery

Biomaterials, Journal Year: 2019, Volume and Issue: 230, P. 119619 - 119619

Published: Nov. 14, 2019

Language: Английский

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Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(21)

Published: March 25, 2019

Abstract Over the past 3 years, glucose oxidase (GOx) has aroused great research interest in context of cancer treatment due to its inherent biocompatibility and biodegradability, unique catalytic properties against β‐ d ‐glucose. GOx can effectively catalyze oxidation into gluconic acid hydrogen peroxide. This process depletes oxygen levels, resulting elevated acidity, hypoxia, oxidative stress tumor microenvironment. All these changes be readily harnessed develop a multimodal synergistic therapy by combining with other therapeutic approaches. Herein, representative studies GOx‐instructed are introduced, their mechanisms discussed systematically. The current challenges future prospects advance development GOx‐based nanomedicines this cutting‐edge area highlighted.

Language: Английский

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Targeting drugs to tumours using cell membrane-coated nanoparticles

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 20(1), P. 33 - 48

Published: Oct. 28, 2022

Language: Английский

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(10)

Published: Jan. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Language: Английский

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Metal-organic frameworks as novel matrices for efficient enzyme immobilization: An update review

Coordination Chemistry Reviews, Journal Year: 2019, Volume and Issue: 406, P. 213149 - 213149

Published: Dec. 20, 2019

Language: Английский

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Metal-organic frameworks for advanced drug delivery

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(8), P. 2362 - 2395

Published: March 14, 2021

Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size shape, easy surface functionalization make this large family more popular for drug delivery. There is a growing interest over the last decades in design engineered MOFs with controlled sizes variety biomedical applications. This article presents an overall review perspectives MOFs-based delivery systems (DDSs), starting classification adapted DDSs based on types constituting metals ligands. Then, synthesis characterization developed, followed by loading strategies, applications, biopharmaceutics quality control. Importantly, representative applications detailed from point view pharmaceutics, diseases therapy advanced DDSs. In particular, control summarized critical issues to be addressed. Finally, challenges development discussed, such as biostability, biosafety, nomenclature.

Language: Английский

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“Armor‐Plating” Enzymes with Metal–Organic Frameworks (MOFs)

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(23), P. 8786 - 8798

Published: Jan. 4, 2020

Cell-free enzymatic catalysis (CFEC) is an emerging biotechnology that enable the biological transformations in complex natural networks to be imitated. This biomimetic approach allows industrial products such as biofuels and biochemical manufactured a green manner. Nevertheless, main challenge CFEC poor stability, which restricts effectiveness lifetime of enzymes sophisticated applications. Immobilization within solid carriers considered efficient strategy for addressing these obstacles. Specifically, putting "armor-like" porous metal-organic framework (MOF) exoskeleton tightly around not only shields against external stimulus, but also selective transport guests through accessible network. Herein we present concept this MOF-entrapped its cutting-edge

Language: Английский

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Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy

Biosensors and Bioelectronics, Journal Year: 2019, Volume and Issue: 137, P. 178 - 198

Published: May 8, 2019

Language: Английский

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