Single-Atom Catalysis for Efficient Sonodynamic Therapy of Methicillin-Resistant Staphylococcus aureus-Infected Osteomyelitis

ACS Nano, Journal Year: 2021, Volume and Issue: 15(6), P. 10628 - 10639

Published: June 4, 2021

Osteomyelitis, as a severe bone disease caused by bacterial infection, can result in lifelong disability or fatal sepsis. Considering that the infection is stubborn and deep-sited tissue, situ rapid treatments for osteomyelitis remain significant challenge. Herein, we prepare an ultrasound (US)-activated single-atom catalyst consists of Au nanorod (NRs)-actuated single-atom-doped porphyrin metal–organic framework (HNTM-Pt@Au) red cell membrane (RBC), which efficiently treat methicillin-resistant Staphylococcus aureus (MRSA)-infected under US. Besides outstanding performance field photocatalysis, find single atoms (such Pt, Au, Cu) also improve sonocatalytic ability sonosensitizer. Due to strong electron-trapping oxygen adsorption capacity, Pt atom endows RBC-HNTM-Pt@Au with excellent activity. It shows antibacterial efficiency 99.9% toward MRSA 15 min US irradiation. Meanwhile, be propelled directionally thus dynamically neutralize secreted toxins. The MRSA-infected rat tibia was successfully treated, negligible loss, reduced inflammation response, great biocompatibility. This work presents efficient sonodynamic therapy treatment deep tissue infections via multifunctional catalyst.

Language: Английский

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Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 12(1), P. 227 - 237

Published: Dec. 12, 2019

S. aureus is resistant to various first-line antibiotics, and seeking multifarious strategies aimed at effective control of antibiotic-resistant behavior urgently needed. Here, we report a two-component directed self-assembly mode: the phytochemicals berberine cinnamic acid can directly self-assemble into nanoparticles (NPs) displaying good bacteriostastic activity. Compared with several obtained nanostructures have better inhibitory effect on multidrug-resistant (MRSA) stronger ability for biofilm removal. These qualities are attributed fact that organic assemblies first spontaneously adhere surface bacteria, infiltrate cell, then lead converging attack against MRSA; thereafter, multipath bactericidal mechanisms NPs MRSA found by both transcriptomic analysis quantitative Polymerase Chain Reaction analysis. Moreover, when combined spectral data single crystal X-ray diffraction, NPs' mechanism governed hydrogen bonds π–π stacking interactions clearly elucidated. non-covalent induce formation butterfly-like one-dimensional self-assembled units finally layered three-dimensional spatial configuration. In addition, biocompatibility tests show nonhemolytic little toxicity in vitro vivo. This mode offer new perspective toward design biocompatible antimicrobial nanomedicines clinical translation.

Language: Английский

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Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 178, P. 113964 - 113964

Published: Sept. 6, 2021

Language: Английский

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Immune Exosomes Loading Self-Assembled Nanomicelles Traverse the Blood–Brain Barrier for Chemo-immunotherapy against Glioblastoma

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 1464 - 1484

Published: Jan. 10, 2023

Effective drug delivery and prevention of postoperative recurrence are significant challenges for current glioblastoma (GBM) treatment. Poor is mainly due to the presence blood–brain barrier (BBB), primarily resistance GBM cells chemotherapeutic drugs an immunosuppressive microenvironment. Herein, a biomimetic nanodrug platform based on endogenous exosomes that could efficiently target brain without targeting modifications co-deliver pure nanomicelles immune adjuvants safe efficient chemo-immunotherapy against prepared. Inspired by self-assembly technology small molecules, tanshinone IIA (TanIIA) glycyrrhizic acid (GL), which inhibitors signal transducers activators transcription 3 from traditional Chinese medicine (TCM), self-assembled form TanIIA-GL (TGM). Endogenous serum selected coat nanomicelles, CpG oligonucleotides, agonists Toll-like receptor 9, anchored exosome membrane obtain loaded with TCM (CpG-EXO/TGM). Our results demonstrate CpG-EXO/TGM can bind free transferrin in blood, prolong blood circulation, maintain intact structures when traversing BBB cells. In microenvironment, strong anti-GBM effect attributed two factors: (i) highly uptake sufficient intracellular release induce apoptosis (ii) stimulation dendritic cell maturation induction tumor-associated macrophages polarization oligonucleotides generate responses. Further research found not only produce better efficacy combination temozolomide but also prevent recurrence.

Language: Английский

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Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 176, P. 113870 - 113870

Published: July 16, 2021

Language: Английский

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Abundant tannic acid modified gelatin/sodium alginate biocomposite hydrogels with high toughness, antifreezing, antioxidant and antibacterial properties

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 309, P. 120702 - 120702

Published: Feb. 16, 2023

Language: Английский

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Natural Carrier‐Free Binary Small Molecule Self‐Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response

Small, Journal Year: 2022, Volume and Issue: 19(5)

Published: Nov. 29, 2022

Methicillin-resistant Staphylococcus aureus (MRSA)-infected skin wounds have caused a variety of diseases and seriously endanger global public health. Therefore, multidimensional strategies are urgently to find antibacterial dressings combat bacterial infections. Antibacterial hydrogels considered potential wound dressing, while their clinical translation is limited due the unpredictable risks high costs carrier excipients. it found that natural star anti-inflammatory phytochemicals baicalin (BA) sanguinarine (SAN) can directly self-assemble through non-covalent bonds such as electrostatic attraction, π-π stacking, hydrogen bonding form carrier-free binary small molecule hydrogel. In addition, BA-SAN gel exhibited synergistic inhibitory effect on MRSA. And its plasticity injectability allowed be applied dressing. Due matched physicochemical properties therapeutic effects, inhibit virulence factors, alleviate inflammation, promote healing, has good biocompatibility. The current study not only provided an hydrogel with value but also opened up new prospects designed originated from clinically used small-molecule phytochemicals.

Language: Английский

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Research progress on self-assembled nanodrug delivery systems

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(12), P. 1908 - 1922

Published: Jan. 1, 2022

This review summarizes the research progress and applications of different types self-assembled nanodrug delivery systems, which are expected to have potential therapeutic value in field biomedicine future.

Language: Английский

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Entropy‐Mediated High‐Entropy MXenes Nanotherapeutics: NIR‐II‐Enhanced Intrinsic Oxidase Mimic Activity to Combat Methicillin‐Resistant Staphylococcus Aureus Infection

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(26)

Published: March 21, 2023

Bacterial infections, such as bacterial keratitis (BK) and subcutaneous abscess, pose significant challenges to global healthcare. Innovative new antibacterial agents strategies are in demand control infections this era of high drug resistance. Nanotechnology is gradually emerging an economically feasible effective anti-infection treatment. High-entropy MXenes (HE MXenes) used confer desirable properties with exposed active sites high-entropy atomic layers, whose potential application the field biomedicine remains be explored. Herein, monolayer HE fabricated by implementing transition metals entropy low Gibbs free energy fill gap biocatalytic performance non-high-entropy MXenes. endowed extremely strong oxidase mimic activity (Km = 0.227 mm) photothermal conversion efficiency (65.8%) second near-infrared (NIR-II) biowindow increases. Subsequently, realize NIR-II-enhanced intrinsic for killing methicillin-resistant Staphylococcus aureus rapidly removing biofilm. Furthermore, can effectively treat BK abscess infection induced nanotherapeutic minuscule side effects. Overall, demonstrate promising clinical treatment drug-resistant promote healing infected tissues.

Language: Английский

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Recent Progress of Electrospun Herbal Medicine Nanofibers

Biomolecules, Journal Year: 2023, Volume and Issue: 13(1), P. 184 - 184

Published: Jan. 16, 2023

Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability extract raw herbs bioactive compounds is poor because their water solubility. In order to overcome solubility issues, electrospinning technology can offer delivery alternative resolve them. The electrospun fibers have advantages high specific surface area, porosity, excellent mechanical strength flexible structures. At same time, various natural synthetic polymer-bound mimic extracellular matrix applications in different fields. this paper, development polymers used for incorporating herbal into nanofibers are reviewed. Finally, recent progress these biomedical (drug delivery, wound dressing, tissue engineering) food fields along future prospects discussed.

Language: Английский

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