Silver Peroxide Nanoparticles for Combined Antibacterial Sonodynamic and Photothermal Therapy

Small, Journal Year: 2021, Volume and Issue: 18(2)

Published: Nov. 5, 2021

Abstract Metal peroxide nanoparticles designed to elevate the oxidative stress are considered a promising nanotherapeutics in biomedical applications, including chemotherapy, photodynamic therapy, and bacterial disinfection. However, their lack of specificity towards therapeutic target can cause toxic side effects healthy tissues. Here, silver (Ag 2 O NPs) capable controlled reactive oxygen species (ROS) release synthesized. The bactericidal Ag + ions ROS is strictly regulated by external stimuli ultrasound (US) near‐infrared (NIR) light. In vitro vivo investigations show that NPs present enhanced antibacterial antibiofilm capabilities with killing efficiency >99.9999% 10 min, significantly accelerate multi‐drug resistant Staphylococcus aureus infected skin wound closure excellent cytocompatibility hemocompatibility. This work not only provides first paradigm for fabricating nanoparticle but also introduces highly efficient noninvasive safe modality combating infectious diseases.

Language: Английский

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NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(38)

Published: July 18, 2022

Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano‐sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining application SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich vacancies developed interlayer gaps trioxide nanobelts expanded. Owing to increased vacancy density wide gap‐induced narrower band gap SMB NPs, electrons (e – ) holes (h + generated by US separated more rapidly, prevent electrons–holes recombination under irradiation. NPs exhibit second near‐infrared (NIR‐II) photothermal effect promote generation ROS sonosensitizer. The system is successfully realized eliminate Staphylococcus aureus ( S. dissipate biofilm. Therefore, multimodal using serves as an effective promising regimen for deep‐seated bacterial infections. newly Mo‐based sonosensitizer presented first time demonstrate excellent antimicrobial activity through hyperthermia‐promoting SDT therapeutics. This work proposes novel strategy field NIR‐II photo‐amplified materials eradication other important biomedical applications.

Language: Английский

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Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Jan. 27, 2022

The emergence of bacterial resistance due to the evolution microbes under antibiotic selection pressure, and their ability form biofilm, has necessitated development alternative antimicrobial therapeutics. Physical stimulation, as a powerful method disrupt microbial structure, been widely used in food industrial sterilization. With advances nanotechnology, nanophysical strategies (NPAS) have provided unprecedented opportunities treat antibiotic-resistant infections, via combination nanomaterials physical stimulations. In this review, NPAS are categorized according modes which include mechanical, optical, magnetic, acoustic, electrical signals. biomedical applications combating infections systematically introduced, with focus on design mechanisms. Current challenges further perspectives clinical treatment also summarized discussed highlight potential use settings. authors hope that review will attract more researchers advance promising field NPAS, provide new insights for designing combat resistance.

Language: Английский

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Sulfur-regulated defect engineering for enhanced ultrasonic piezocatalytic therapy of bacteria-infected bone defects

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134624 - 134624

Published: Jan. 11, 2022

Language: Английский

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Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment

Science Advances, Journal Year: 2023, Volume and Issue: 9(10)

Published: March 8, 2023

Acne is an inflammatory skin disease mainly caused by Propionibacterium acnes, which can cause local reactions and develop into chronic diseases in severe cases. To avoid the use of antibiotics to effectively treat site acne, we report a sodium hyaluronate microneedle patch that mediates transdermal delivery ultrasound-responsive nanoparticles for effective treatment acne. The contains formed zinc porphyrin-based metal-organic framework oxide (ZnTCPP@ZnO). We demonstrated activated oxygen-mediated killing P. acnes with antibacterial efficiency 99.73% under 15 min ultrasound irradiation, resulting decrease levels acne-related factors, including tumor necrosis factor-α, interleukins, matrix metalloproteinases. ions up-regulated DNA replication-related genes, promoting proliferation fibroblasts and, consequently, repair. This research leads highly strategy acne through interface engineering response.

Language: Английский

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Piezo-Augmented Sonosensitizer with Strong Ultrasound-Propelling Ability for Efficient Treatment of Osteomyelitis

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 2546 - 2557

Published: Jan. 19, 2022

The successful treatment of osteomyelitis remains a great challenge in the field orthopedics. clinical method for treating refractory bone infection requires combination therapy long-term systemic antibiotics administration and surgical debridement. It is highly desirable to develop an antibiotic-free, noninvasive, rapid strategy eradicate osteomyelitis. Herein, we fabricate piezoelectric-enhanced sonosensitizer that consists porphyrin-based hollow metal–organic framework (HNTM), MoS2 nanosheets, red cell (RBC) membrane. We find ultrasound (US)-induced piezoelectric polarization can improve charge transfer HNTM at heterointerface HNTM-MoS2, increasing production reactive oxygen species (ROS). Besides, increases asymmetric shape HNTM, leading strong US-propelling ability HNTM–MoS2. produced ROS mechanical force kill methicillin-resistant Staphylococcus aureus (MRSA) with antibacterial efficiency 98.5% under 15 min US treatment, resulting intracellular DNA damage increased oxidative stress disturbance purine metabolism, tryptophan pantothenate CoA biosynthesis MRSA. Together toxin neutralization ability, RBC-HNTM-MoS2 successfully eliminates suppresses inflammation loss. This work provides another developing efficient through piezoelectric-assisted sonocatalysis enhancing ability.

Language: Английский

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Recent developments of sonodynamic therapy in antibacterial application

Nanoscale, Journal Year: 2022, Volume and Issue: 14(36), P. 12999 - 13017

Published: Jan. 1, 2022

This review summarizes the currently available sonosensitizers for antibacterial SDT and digs into innovative biotechnologies to improve efficiency.

Language: Английский

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Amidoxime Group‐Anchored Single Cobalt Atoms for Anti‐Biofouling during Uranium Extraction from Seawater

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Jan. 22, 2022

Marine biofouling is one of the most significant challenges hindering practical uranium extraction from seawater. Single atoms have been widely used in catalytic applications because their remarkable redox property, implying that single atom highly capable catalyzing generation reactive oxygen species (ROS) and acts as an anti-biofouling substance for controlling biofouling. In this study, Co loaded polyacrylamidoxime (PAO) material, PAO-Co, fabricated based on binding ability amidoxime group to uranyl cobalt ions. Nitrogen stabilize atom. The PAO-Co exhibits a broad range antimicrobial activity against diverse marine microorganisms by producing ROS, with inhibition rate up 93.4%. present study first apply adsorbent achieves ultrahigh adsorption capacity 9.7 mg g

Language: Английский

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Engineering single-atom catalysts toward biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3688 - 3734

Published: Jan. 1, 2022

Due to inherent structural defects, common nanocatalysts always display limited catalytic activity and selectivity, making it practically difficult for them replace natural enzymes in a broad scope of biologically important applications. By decreasing the size nanocatalysts, their selectivity will be substantially improved. Guided by this concept, advances now enter an era atomic-level precise control. Single-atom catalysts (denoted as SACs), characterized atomically dispersed active sites, strikingly show utmost atomic utilization, precisely located metal centers, unique metal-support interactions identical coordination environments. Such advantages SACs drastically boost specific per atom, thus provide great potential achieving superior functionally mimic or even outperform interest. Although does matter, is not clear whether guideline "the smaller, better" still correct developing at single-atom scale. Thus, clearly new, urgent issue address before further extending into biomedical applications, representing branch nanomedicine. This review begins providing overview recent synthesis strategies SACs, which serve basis discussion emerging achievements improving enzyme-like properties level. Then, we carefully compare structures functions various scales from nanoparticles, nanoclusters, few-atom clusters single atoms. Contrary conventional wisdom, are most catalytically reactions, especially those requiring multi-site auxiliary activities. After that, highlight roles toward To appreciate these advances, challenges prospects rapidly growing studies SACs-related nanomedicine also discussed review.

Language: Английский

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Recent advances in nanoparticle-mediated antibacterial applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215075 - 215075

Published: Feb. 21, 2023

Language: Английский

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