Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 225 - 257
Published: May 7, 2024
The
number
of
multi-drug-resistant
bacteria
has
increased
over
the
last
few
decades,
which
caused
a
detrimental
impact
on
public
health
worldwide.
In
resolving
antibiotic
resistance
development
among
different
bacterial
communities,
new
antimicrobial
agents
and
nanoparticle-based
strategies
need
to
be
designed
foreseeing
slow
discovery
functioning
antibiotics.
Advanced
research
studies
have
revealed
significant
disinfection
potential
two-dimensional
nanomaterials
(2D
NMs)
severed
as
effective
antibacterial
due
their
unique
physicochemical
properties.
This
review
covers
current
progress
2D
NMs-based
based
an
inclusive
explanation
NMs'
agents,
including
detailed
introduction
each
possible
well-known
mechanism.
properties
NMs
activities
been
deliberated
while
explaining
toxic
effects
discussing
biomedical
significance,
dysbiosis,
cellular
nanotoxicity.
Adding
challenges,
we
also
discussed
major
issues
regarding
quality
availability
nanotoxicity
data.
However,
smart
advancements
are
required
fabricate
biocompatible
exploit
combat
clinically.
Small,
Journal Year:
2021,
Volume and Issue:
18(2)
Published: Nov. 5, 2021
Abstract
Metal
peroxide
nanoparticles
designed
to
elevate
the
oxidative
stress
are
considered
a
promising
nanotherapeutics
in
biomedical
applications,
including
chemotherapy,
photodynamic
therapy,
and
bacterial
disinfection.
However,
their
lack
of
specificity
towards
therapeutic
target
can
cause
toxic
side
effects
healthy
tissues.
Here,
silver
(Ag
2
O
NPs)
capable
controlled
reactive
oxygen
species
(ROS)
release
synthesized.
The
bactericidal
Ag
+
ions
ROS
is
strictly
regulated
by
external
stimuli
ultrasound
(US)
near‐infrared
(NIR)
light.
In
vitro
vivo
investigations
show
that
NPs
present
enhanced
antibacterial
antibiofilm
capabilities
with
killing
efficiency
>99.9999%
10
min,
significantly
accelerate
multi‐drug
resistant
Staphylococcus
aureus
infected
skin
wound
closure
excellent
cytocompatibility
hemocompatibility.
This
work
not
only
provides
first
paradigm
for
fabricating
nanoparticle
but
also
introduces
highly
efficient
noninvasive
safe
modality
combating
infectious
diseases.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(38)
Published: July 18, 2022
Abstract
Ultrasound
(US)‐mediated
sonodynamic
therapy
(SDT)
has
the
advantages
of
non‐invasiveness
and
deep
tissue
penetration.
Nanosystems
are
prominently
used
in
sonosensitization;
however,
most
nano‐sonosensitizers
have
a
low
reactive
oxygen
species
(ROS)
yield,
thus
restraining
application
SDT.
Sodium
molybdenum
bronze
nanoparticles
(SMB
NPs)
with
rich
vacancies
developed
interlayer
gaps
trioxide
nanobelts
expanded.
Owing
to
increased
vacancy
density
wide
gap‐induced
narrower
band
gap
SMB
NPs,
electrons
(e
–
)
holes
(h
+
generated
by
US
separated
more
rapidly,
prevent
electrons–holes
recombination
under
irradiation.
NPs
exhibit
second
near‐infrared
(NIR‐II)
photothermal
effect
promote
generation
ROS
sonosensitizer.
The
system
is
successfully
realized
eliminate
Staphylococcus
aureus
(
S.
dissipate
biofilm.
Therefore,
multimodal
using
serves
as
an
effective
promising
regimen
for
deep‐seated
bacterial
infections.
newly
Mo‐based
sonosensitizer
presented
first
time
demonstrate
excellent
antimicrobial
activity
through
hyperthermia‐promoting
SDT
therapeutics.
This
work
proposes
novel
strategy
field
NIR‐II
photo‐amplified
materials
eradication
other
important
biomedical
applications.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(10)
Published: Jan. 27, 2022
The
emergence
of
bacterial
resistance
due
to
the
evolution
microbes
under
antibiotic
selection
pressure,
and
their
ability
form
biofilm,
has
necessitated
development
alternative
antimicrobial
therapeutics.
Physical
stimulation,
as
a
powerful
method
disrupt
microbial
structure,
been
widely
used
in
food
industrial
sterilization.
With
advances
nanotechnology,
nanophysical
strategies
(NPAS)
have
provided
unprecedented
opportunities
treat
antibiotic-resistant
infections,
via
combination
nanomaterials
physical
stimulations.
In
this
review,
NPAS
are
categorized
according
modes
which
include
mechanical,
optical,
magnetic,
acoustic,
electrical
signals.
biomedical
applications
combating
infections
systematically
introduced,
with
focus
on
design
mechanisms.
Current
challenges
further
perspectives
clinical
treatment
also
summarized
discussed
highlight
potential
use
settings.
authors
hope
that
review
will
attract
more
researchers
advance
promising
field
NPAS,
provide
new
insights
for
designing
combat
resistance.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(10)
Published: March 8, 2023
Acne
is
an
inflammatory
skin
disease
mainly
caused
by
Propionibacterium
acnes,
which
can
cause
local
reactions
and
develop
into
chronic
diseases
in
severe
cases.
To
avoid
the
use
of
antibiotics
to
effectively
treat
site
acne,
we
report
a
sodium
hyaluronate
microneedle
patch
that
mediates
transdermal
delivery
ultrasound-responsive
nanoparticles
for
effective
treatment
acne.
The
contains
formed
zinc
porphyrin-based
metal-organic
framework
oxide
(ZnTCPP@ZnO).
We
demonstrated
activated
oxygen-mediated
killing
P.
acnes
with
antibacterial
efficiency
99.73%
under
15
min
ultrasound
irradiation,
resulting
decrease
levels
acne-related
factors,
including
tumor
necrosis
factor-α,
interleukins,
matrix
metalloproteinases.
ions
up-regulated
DNA
replication-related
genes,
promoting
proliferation
fibroblasts
and,
consequently,
repair.
This
research
leads
highly
strategy
acne
through
interface
engineering
response.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 2546 - 2557
Published: Jan. 19, 2022
The
successful
treatment
of
osteomyelitis
remains
a
great
challenge
in
the
field
orthopedics.
clinical
method
for
treating
refractory
bone
infection
requires
combination
therapy
long-term
systemic
antibiotics
administration
and
surgical
debridement.
It
is
highly
desirable
to
develop
an
antibiotic-free,
noninvasive,
rapid
strategy
eradicate
osteomyelitis.
Herein,
we
fabricate
piezoelectric-enhanced
sonosensitizer
that
consists
porphyrin-based
hollow
metal–organic
framework
(HNTM),
MoS2
nanosheets,
red
cell
(RBC)
membrane.
We
find
ultrasound
(US)-induced
piezoelectric
polarization
can
improve
charge
transfer
HNTM
at
heterointerface
HNTM-MoS2,
increasing
production
reactive
oxygen
species
(ROS).
Besides,
increases
asymmetric
shape
HNTM,
leading
strong
US-propelling
ability
HNTM–MoS2.
produced
ROS
mechanical
force
kill
methicillin-resistant
Staphylococcus
aureus
(MRSA)
with
antibacterial
efficiency
98.5%
under
15
min
US
treatment,
resulting
intracellular
DNA
damage
increased
oxidative
stress
disturbance
purine
metabolism,
tryptophan
pantothenate
CoA
biosynthesis
MRSA.
Together
toxin
neutralization
ability,
RBC-HNTM-MoS2
successfully
eliminates
suppresses
inflammation
loss.
This
work
provides
another
developing
efficient
through
piezoelectric-assisted
sonocatalysis
enhancing
ability.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(9), P. 3688 - 3734
Published: Jan. 1, 2022
Due
to
inherent
structural
defects,
common
nanocatalysts
always
display
limited
catalytic
activity
and
selectivity,
making
it
practically
difficult
for
them
replace
natural
enzymes
in
a
broad
scope
of
biologically
important
applications.
By
decreasing
the
size
nanocatalysts,
their
selectivity
will
be
substantially
improved.
Guided
by
this
concept,
advances
now
enter
an
era
atomic-level
precise
control.
Single-atom
catalysts
(denoted
as
SACs),
characterized
atomically
dispersed
active
sites,
strikingly
show
utmost
atomic
utilization,
precisely
located
metal
centers,
unique
metal-support
interactions
identical
coordination
environments.
Such
advantages
SACs
drastically
boost
specific
per
atom,
thus
provide
great
potential
achieving
superior
functionally
mimic
or
even
outperform
interest.
Although
does
matter,
is
not
clear
whether
guideline
"the
smaller,
better"
still
correct
developing
at
single-atom
scale.
Thus,
clearly
new,
urgent
issue
address
before
further
extending
into
biomedical
applications,
representing
branch
nanomedicine.
This
review
begins
providing
overview
recent
synthesis
strategies
SACs,
which
serve
basis
discussion
emerging
achievements
improving
enzyme-like
properties
level.
Then,
we
carefully
compare
structures
functions
various
scales
from
nanoparticles,
nanoclusters,
few-atom
clusters
single
atoms.
Contrary
conventional
wisdom,
are
most
catalytically
reactions,
especially
those
requiring
multi-site
auxiliary
activities.
After
that,
highlight
roles
toward
To
appreciate
these
advances,
challenges
prospects
rapidly
growing
studies
SACs-related
nanomedicine
also
discussed
review.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(50)
Published: Oct. 17, 2022
Osteomyelitis
caused
by
methicillin-resistant
Staphylococcus
aureus
(MRSA)
biofilm
infection
is
difficult
to
eradicate
and
can
even
be
life-threatening.
Given
that
the
persistent
deep-seated
in
bone
tissue,
controlled
efficient
treatment
of
osteomyelitis
remains
challenging.
Herein,
an
activatable
nanostructure
(Au/TNT@PG)
presented
for
synergistic
sonodynamic-catalytic
therapy
MRSA-infected
osteomyelitis.
The
Au/TNT@PG
backbone
obtained
conjugating
a
guanidinium-rich
polymer
(PG),
component
penetrates
matrix,
onto
ultrasound
(US)-absorbing
gold-doped
titanate
nanotubes
(Au/TNTs).
Under
deep-penetrating
US
irradiation,
nanocomposite
generates
1
O2
sonodynamic
catalyzes
decomposition
endogenous
H2
into
toxic
•OH
acidic
microenvironment
catalytic
therapy,
leading
bacterial
cell
death.
Its
robust
antibacterial
effectiveness
attributable
its
bacteria-capturing
ability,
penetrability
positively
charged
guanidinium,
subsequent
effect
action
Au/TNT.
Such
remotely
approach
potentiates
polarization
macrophages
M2-type
while
suppressing
M1-type,
topical
inflammation
resolution
enhanced
osteoblast
proliferation
differentiation
inhibit
loss.
Therefore,
this
study
provides
generic
nanotherapeutic
with
respect
