Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window DOI Creative Commons

Xunzhi Wu,

Yongkuan Suo,

Hui Shi

et al.

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 12(1)

Published: Jan. 24, 2020

Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, second (NIR-II; 1000–1700 especially NIR-IIa (1300–1400 is considered much more promising diagnosis superiority penetration depth maximum permissible exposure over NIR-I window. Hereby, we propose use laser excitation at 1275 nm, which approved by Food Drug Administration physical therapy, an attractive technique to balance tissue absorption scattering with water absorption. Specifically, CuS-PEG nanoparticles similar values 808 a conventional PTT, were synthesized agents comparison platform, explore potential nm deep-tissue settings. results showed that was practicable PTT. It exhibited desirable outcomes cell ablation vitro antitumor capabilities vivo compared laser. illumination superior shows high improve outcome.

Language: Английский

Organic Semiconducting Macromolecular Dyes for NIR‐II Photoacoustic Imaging and Photothermal Therapy DOI
Chao Yin, Xiaozhen Li, Yi Wang

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(37)

Published: June 26, 2021

Abstract Owing to the unique advantages of photoacoustic imaging (PAI) and photothermal therapy (PTT) conducted over near‐infrared‐II (NIR‐II) window, development high‐efficiency optical agents with NIR‐II light responsiveness is great significance. Despite diversity developed for PAI PTT, most them are based on inorganic nanomaterials small molecular dyes, whose biosafety photostability need be further assessed, respectively. Organic semiconducting macromolecular dyes (OSMDs) featuring a large backbone becoming alternative candidates PTT owing their reliable biocompatibility, durable photostability, ideal conversion capability. This paper reviews current progress OSMD‐based in window. The three main types OSMDs different skeleton architectures introduced, applications (tumor imaging, stem cell tracking, vasculature imaging) ablation) described. Viable strategies improving performance discussed. Finally, some major issues faced by raised, future directions analyzed.

Language: Английский

Citations

122
NIR-II light in clinical oncology: opportunities and challenges DOI
Zeyu Zhang, Yang Du, Xiaojing Shi

et al.

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

Citations

85
A NIR‐II AIEgen‐Based Supramolecular Nanodot for Peroxynitrite‐Potentiated Mild‐Temperature Photothermal Therapy of Hepatocellular Carcinoma DOI
Haitao Hu, Dan Li, Wenbin Dai

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(19)

Published: Feb. 13, 2023

Abstract Compared to conventional photothermal therapy (PTT) which requires hyperthermia higher than 50 °C, mild‐temperature PTT is a more promising antitumor strategy with much lower phototoxicity neighboring normal tissues. However, the therapeutic efficacy of always restricted by thermoresistance cancer cells. To address this issue, supramolecular drug nanocarrier fabricated co‐deliver nitric oxide (NO) and agent DCTBT NIR‐II aggregation‐induced emission (AIE) characteristic for PTT. NO can be effectively released from nanocarriers in intracellular reductive environment capable simultaneously producing reactive oxygen species (ROS) upon 808 nm laser irradiation. The generated ROS further react produce peroxynitrite (ONOOˉ) bearing strong oxidization nitration capability. ONOOˉ inhibit expression heat shock proteins (HSP) reduce cells, necessary achieve excellent DCTBT‐based at mild temperature (<50 °C). performance ONOOˉ‐potentiated validated on subcutaneous orthotopic hepatocellular carcinoma (HCC) models. This research puts forward an innovative overcome PTT, provides new inspirations explore ONOOˉ‐sensitized tumor strategies.

Language: Английский

Citations

69
Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics DOI
Jiangao Li,

Miaomiao Kang,

Zhijun Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 17, 2023

Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual-acceptor engineering strategy exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π-conjugation degrees, making full use active intramolecular motion-induced effect. The optimal polymer SP4 synchronously shows desirable second near-infrared (NIR-II) absorption, extremely satisfactory behavior. Consequently, unprecedented performance NPs 1064 nm laser-excited photoacoustic imaging (PAI)-guided therapy (PTT) demonstrated tumor diagnosis complete elimination.

Language: Английский

Citations

59
Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy DOI
Ruiliang Ge,

Pei-ning Yan,

Yang Liu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: June 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Language: Английский

Citations

57
Photothermal “nano-dot” reactivate “immune-hot” for tumor treatment via reprogramming cancer cells metabolism DOI
Lu Yang, Yang Wang, Weijian Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 296, P. 122089 - 122089

Published: March 6, 2023

Language: Английский

Citations

51
NIR‐II absorbing organic nanoagents for photoacoustic imaging and photothermal therapy DOI Creative Commons
Wei Shao, Fulai Zhao, Jinhong Xue

et al.

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Jan. 30, 2023

Abstract Near‐infrared (NIR) absorbing materials hold great potential in biomedical applications, such as fluorescence imaging (FLI), photoacoustic (PAI), photodynamic therapy (PDT), and photothermal (PTT). Generally, these can be classified into two main categories based on their wavelengths: the first NIR (NIR‐I) (~650–950 nm) second (NIR‐II) (~1000–1700 materials. Due to reduced absorption scattering of NIR‐II light tissue compared NIR‐I light, enable with improved contrast deepened penetration, which is favor practical applications. Various inorganic have been developed for phototheranostics recent years. However, non‐biodegradability toxicity hinder further clinical translation. Biocompatible organic biodegradability well tailored optical property are thus more desired. In this review, we summarize advances nanoagents (ONAs) small molecules (SMs) conjugated polymers (CPs) PAI PTT show our perspectives future challenges development

Language: Английский

Citations

46
Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo DOI
Qinrui Fu, Xiao Yang, Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

Citations

32
NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma DOI

Xueyang Fang,

Rui Gong,

Decai Yang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(22), P. 15251 - 15263

Published: May 23, 2024

Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.

Language: Английский

Citations

24
NIR‐II Excitable Semiconducting Polymers with AIE Characteristics for Fluorescence‐Photoacoustic Imaging‐Guided Synergistic Phototherapy DOI
Jiangao Li, Zhijun Zhang, Shanshan Jiang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: March 22, 2024

Abstract The development of semiconducting polymers (SPs) with simultaneous second near‐infrared (NIR‐II) absorption and multimodal phototheranostic functions is highly desired in the field oncotherapy. Aggregation‐induced emission luminogens (AIEgens) have been acknowledged to possess unique potential integrating multiple diagnostic therapeutic modalities into one organic molecule. Nevertheless, SPs are hard achieve AIE activity due their extended π‐conjugated skeletons as well large planar configuration commonly‐used electrophilic acceptor moieties. Herein, an ingenious dimerization‐based distortion strategy proposed current work by taking advantage sterically encumbered acceptors structure for successful construction AIE‐active SPs. Through further finely adjusting molecular donor–acceptor interaction strength, obtained named SP3 bearing highest intramolecular charge transfer effect presented NIR‐II aggregation‐induced fluorescence emission, good reactive oxygen species production ability, superior photothermal conversion performance. Accordingly, selected fabricate nanoparticles successfully applied laser‐triggered fluorescence‐photoacoustic imaging‐guided photodynamic‐photothermal therapy tumors. This study represents first excitable SP, offers a new perspective on designing advanced efficient treatment malignant tumor.

Language: Английский

Citations

21