The influence of chirality on the structure of a tartaric acid-choline chloride deep eutectic solvent DOI Creative Commons

Elly K. Bathke,

Daniel T. Bowron, Iva Manasi

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 402, P. 124735 - 124735

Published: April 17, 2024

The wide range of properties, relative ease and low cost using Deep Eutectic Solvents garners them interest in an ever expanding applications. Among common DES components many are naturally occurring chiral molecules. Here we present the liquid structure either single enantiomeric or racemic tartaric acid with choline chloride (molar ratio 2 to 1 acid), as well influence amounts added water (2:1:2) from neutron scattering data H/D isotropic substitution, refined empirical potential refinement. We show that overall remains same between different enatiomeric compositions, small differences interactions only is also robust towards hydration, similar what has been found other DES. compare our structures comprising carboxylic acids (1:1 - malic acid, 1:1 oxalic finding dominant interactions, may be attributable number available hydrogen bonding sites steric effects.

Language: Английский

Facile Synthesis of Bis‐Coumarins Using [BCMIM][Cl] Zwitter Ionic Liquid and Their Binding with Bovine Serum Albumin DOI Open Access
Sai Deepak Pasuparthy, Suman Joseph, Pranati Somkuwar

et al.

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(8)

Published: July 6, 2023

Abstract Herein, we report a novel synthetic pathway for synthesizing bis‐coumarins using 5 mol% [BCMIM][Cl] ionic liquid via the facile, one‐pot, metal‐free synthesis in aqueous ethanol at room temperature. A series of 24 derivatives were furnished up to 94% yields 15 min 1.5 h and characterized different spectroscopic techniques. The photophysical properties bis‐coumarin explored through UV‐Visible fluorescence spectroscopy. absorption emission spectra demonstrate peak wavelength (λ max ), within range 297–311 nm 486–505 nm, respectively. An analogous pattern experimental results is seen density functional calculations. binding affinities all synthesised with Bovine Serum Albumin (BSA) determined AutoDock Vina which exhibited from −8.4 −11.5 kcal mol −1 . computed constant (K BSA ) by tryptophan (Trp) quenching values illustrate strong interactions selected ligands order 10 4 calculated validated performing molecular dynamics simulations best docking pose GROMACS software over period 1 ns studying stability protein‐ligand complexes.

Language: Английский

Citations

7
Synthetic Routes to Access Dicarbonylated Aryls and Heteroaryls DOI
Swadhin Swaraj Acharya, Bibhuti Bhusan Parida

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The regioselective 1,2-dicarbonylation of aryls and heteroaryls offers access to functionalized dicarbonylated heteroaryls, which opens pharmaceuticals bioactive molecules with diverse synthetic utility.

Language: Английский

Citations

2
Deep Eutectic Solvent (DES)-Mediated One-Pot Multicomponent Green Approach for Naphthalimide-Centered Acridine-1,8-dione Derivatives and Their Photophysical Properties DOI Creative Commons
Ishfaq Ahmad Rather, Saad H. Alotaibi, Mohammed T. Alotaibi

et al.

ACS Omega, Journal Year: 2022, Volume and Issue: 7(40), P. 35825 - 35833

Published: Sept. 26, 2022

An efficient and green methodology to assemble various functionalized naphthalimide-centered acridine-1,8-dione derivatives involving a one-pot multicomponent protocol has successfully been developed. Herein, variety of aromatic aldehydes, 1,3-diketones, 1,8-naphthanoic anhydride, hydrazine hydrate have condensed under reusable, inexpensive, biodegradable deep eutectic solvent (DES) N,N′-dimethyl urea l-(+)-tartaric acid obtain the desired targets operationally mild reaction conditions with outstanding conversions. Strikingly, in this strategy, DES plays dual role catalyst was recycled efficiently four consecutive runs no substantial drop yield product. Interestingly, easy recovery high reusability make simple yet environmentally desirable. Moreover, preliminary photophysical properties thus-prepared valuable molecules also investigated by ultraviolet–visible (UV–vis) fluorescence spectroscopy.

Language: Английский

Citations

9
Cesium salt of tungstophosphoric acid/mesoporous (zirconia–silica) composite for highly efficient synthesis of 7-hydroxy-4-methyl coumarin and removal of methylene blue DOI Creative Commons
Amr Awad Ibrahim,

Doaa A. Kospa,

O. R. Hayes

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(22), P. 15243 - 15260

Published: Jan. 1, 2023

The removal of harmful organic dyes from aqueous solutions has drawn the attention scientists because substantial threat they pose to society's worldwide health. Hence, it is crucial design an adsorbent that both very effective in removing and benefit being inexpensive. In present work, Cs salts tungstophosphoric acid (CPW) supported mesoporous Zr-mSiO2 (mZS) with varying extents ions have been prepared by a two-step impregnation technique. Accordingly, lowering surface acidity modes was observed after exchanged protons H3W12O40 formed immobilized on mZS support. After exchanging ions, characterization results revealed primary Keggin structure unaltered. Moreover, catalysts had higher area than parent H3W12O40/mZS, suggesting reacts molecules create new particles smaller sizes possessing inter-crystallite centers dispersion degree. With increase content thus decrease strength density, methylene blue (MB) monolayer adsorption capacities CPW/mZS were increased reached uptake capacity 359.9 mg g-1 for Cs3PW12O40/mZS (3.0CPW/mZS). catalytic formation 7-hydroxy-4-methyl coumarin also studied at optimum conditions found activity influenced amount exchangeable PW mZrS support, which turn catalyst acidity. kept approximately initial even fifth cycle.

Language: Английский

Citations

5
The Paal–Knorr Pyrroles Synthesis: A Green Perspective DOI

Shakeel Alvi,

Ahmad Hasan,

Rashid Ali

et al.

Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(5), P. 3558 - 3575

Published: June 27, 2023

It is still believed that the progress of Green Chemistry necessities to upsurge at a higher pace, if 'molecular science' meet encounters sustainability. And it also aforesaid revolution particular day becomes new-fangled belief next. Therefore, keeping importance sustainability as well green chemistry in mind, herein we report perspective very well-known named reaction, dubbed Paal–Knorr pyrrole synthesis. In this document, have tried cover some interesting synthetic approaches belonging class. We hope review article will be useful researchers working organic general and heterocyclic particular.

Language: Английский

Citations

5
A Simple and Effective Protocol for the Pechmann Reaction to Obtain 4-Methylcoumarin Derivatives Using a High-Speed Mixer Ball Mill Process DOI Creative Commons

Silvia J. Becerra-Anaya,

Diego R. Merchán-Arenas, Vladímir V. Kouznetsov

et al.

Chemistry, Journal Year: 2023, Volume and Issue: 5(2), P. 1077 - 1088

Published: May 8, 2023

We hereby report a simple and efficient method for the preparation of 4-methylcoumarins series, including Coumarin 120 (7-amino-4-methylcoumarin) from phenols (or naphthols) ethyl acetoacetate in presence 3 mol% InCl3. Coumarins were obtained good yields (52–92%) through Pechmann condensation, under rapid environmentally friendly protocol using high-speed ball mill mixer at room temperature, with short reaction times, solvent-free conditions.

Language: Английский

Citations

5
Operationally simple, scalable synthesis of aryloxy propanolamines using glycerol as a green promoting media: Practical eco-friendly access to propranolol and atenolol DOI
Mohammad Saquib, Mohammad Faheem Khan,

Jaya Singh

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2022, Volume and Issue: 30, P. 100860 - 100860

Published: Nov. 3, 2022

Language: Английский

Citations

8
Unraveling the Potential Role of Deep Eutectic Solvents (DESs): Synthesis of Ketazines & Pyrazolines DOI
Shafieq Ahmad Wagay, Rashid Ali

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 2, 2023

Abstract Increasing demand to curtail the usage of hazardous organic solvents, reagents and/or catalysts, has engrossed interest scientific community towards development next generation liquid media, commonly known as ‘deep eutectic solvents’ (DESs). Bearing significant role ketazine and pyrazoline derivatives in mind, herein, after screening various DESs for condensation ketones hydrazine followed by cyclization produce corresponding pyrazolines, a low melting mixture citric acid: N,N ‐dimethyl urea (CA:DMU) 2 : 3 ratio was found be best choice this particular transformation. Interestingly, recycled easily reused up four times without affecting yield product greater extent. Hopefully, method may useful generate different kinds valuable ketazines well years come.

Language: Английский

Citations

4
A novel ionic liquid immobilized on FSM-16: a novel recoverable nanocatalyst for the synthesis of biscoumarin derivatives DOI

Azar Jahanbakhshi,

Sanaz Eskandari,

Mahnaz Farahi

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 48(3), P. 1381 - 1389

Published: Dec. 6, 2023

In order to extend the use of supported ionic liquids as effective heterogeneous catalysts, in this research, a novel FSM-16 Brønsted acidic liquid (FSM-16-IL-SO 3 H) was synthesized and characterized using various techniques such FT-IR, TGA, SEM, EDX, XRD, BET.

Language: Английский

Citations

4
Cyclodextrins - Core Concepts and New Frontiers DOI
Rashid Ali,

Rimsha Yousaf,

Abdul Fizza

et al.

IntechOpen eBooks, Journal Year: 2022, Volume and Issue: unknown

Published: July 12, 2022

Cyclodextrins (CDs) have attracted great interest from the research community as well industries in an array of sectors because their unique structural features. This book provides a comprehensive overview CDs, beginning with historical background. Chapters address such topics structure and physiochemical properties advancements field, potential applications these materials fields drug delivery sensing. reveals new frontiers CD world is useful resource for organic, analytical, supramolecular chemists scientists engaged biological material sciences.

Language: Английский

Citations

7