Sustainable bioinspired materials for regenerative medicine: balancing toxicology, environmental impact, and ethical considerations

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(6), P. 060501 - 060501

Published: Oct. 10, 2024

The pursuit of sustainable bioinspired materials for regenerative medicine demands a nuanced balance between scientific advancement, ethical considerations, and environmental consciousness. This abstract encapsulates comprehensive perspective paper exploring the intricate dynamics toxicology, impact, concerns within realm materials. As landscape evolves, ensuring biocompatibility safety these emerges as pivotal challenge. Our delves into multidimensional aspects toxicity assessment, encompassing cytotoxicity, genotoxicity, immunotoxicity analyses. Additionally, we shed light on complexities evaluating impact materials, discussing methodologies such life cycle biodegradability testing, design approaches. Amid endeavors, emphasize paramount importance considerations in material development, navigating web international regulations frameworks guiding medical Furthermore, our underscores envisioned future directions challenges toxicology techniques, computational modeling, holistic evaluation, aiming understanding synergistic interplay stewardship, deliberation.

Language: Английский

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Translational nanorobotics breaking through biological membranes

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In the dynamic realm of translational nanorobotics, endeavor to develop nanorobots carrying therapeutics in rational vivo applications necessitates a profound understanding biological landscape human body and its complexity. Within this landscape, membranes stand as critical barriers successful delivery therapeutic cargo target site. Their crossing is not only challenge for nanorobotics but also pivotal criterion clinical success therapeutic-carrying nanorobots. Nevertheless, despite their urgency, strategies membrane remain relatively underrepresented scientific literature, signaling an opportunity further research innovation. This review focuses on with various propulsion mechanisms from chemical physical hybrid mechanisms, it identifies describes four essential that represent needed be crossed journey applications. First entry point into blood stream, which skin or mucosa intravenous injection; next exit bloodstream across endothelium site; cell through plasma and, finally, escape lysosome, otherwise destroys cargo. The discusses design challenges inherent translating nanorobot technologies real-world provides overview documented crossings. aim underscore need interdisciplinary collaborations between chemists, materials scientists biologists vital domain has potential revolutionize field precision medicine.

Language: Английский

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Charged Fibrous Dressing to Promote Diabetic Chronic Wound Healing

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(2)

Published: Oct. 13, 2023

Diabetic chronic wounds cause a significant amount of pain to patients because their low cure rates and high recurrence rates. Traditional approaches treating diabetic often involve the delivery drugs or cytokines that regulate microenvironment eliminate bacterial infection in wound area, but they are passive controlling cell behaviors may lead drug resistance. Emerging drug-free treatments important for convenient, effective, safe treatment strategies. However, current cannot fully promote tissue regeneration prevent infections. Here, efficacy negatively charged fiber dressing promoting healing is investigated. The can generate reactive oxygen species inhibit reproduction with assistance ultrasound during inflammatory phase. Furthermore, provides an electrostatic field regulates cellular behavior proliferative phases. In particular, fibroblast migration induce macrophage polarization neovascularization without any additional drugs. It demonstrated this strategy enables mouse model, achieving effective closure over 12-day cycle providing therapeutic care.

Language: Английский

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Insights into artificial intelligence utilisation in drug discovery

Journal of Medical Economics, Journal Year: 2024, Volume and Issue: 27(1), P. 304 - 308

Published: Feb. 22, 2024

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Biogenic Zinc Oxide Nanoparticles: An Insight into the Advancements in Antimicrobial Resistance

ECS Journal of Solid State Science and Technology, Journal Year: 2024, Volume and Issue: 13(4), P. 047002 - 047002

Published: April 1, 2024

Multidrug resistance (MDR) is a significant global challenge requiring strategic solutions to address bacterial infections. Recent advancements in nanotechnology, particularly the synthesis of zinc oxide nanoparticles (ZnO NPs) using natural agents as stabilizers and reducing agents, have shown promising results combating MDR. These possess strong antimicrobial properties against different strains Gram-positive Gram-negative, making them suitable for various industries, including food, pharmaceuticals, coatings, medical devices. ZnO-NPs work by generating reactive oxygen species, releasing ions (Zn2+), disrupting cell membrane, interfering with metabolic processes genetic material, inducing oxidative stress apoptosis. However, more research needed refine techniques, control size morphology, increase antibacterial efficacy. To fully understand their potential, interactions proteins, DNA, walls must also be examined. Investigating synergistic potential biogenic ZnO NPs conventional treatments could enhance therapeutic effectiveness while minimizing risk emergence. Here we provide insight into bio extracts applications well factors affecting process characterization techniques NPs. studies on activity pathogens mechanisms action are discussed. Furthermore, highlighted.

Language: Английский

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Holotomography and atomic force microscopy: a powerful combination to enhance cancer, microbiology and nanotoxicology research

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 9, 2024

Modern imaging strategies are paramount to studying living systems such as cells, bacteria, and fungi their response pathogens, toxicants, nanomaterials (NMs) modulated by exposure environmental factors. The need understand the processes mechanisms of damage, healing, cell survivability continues motivate development alternative strategies. Of particular interest is use label-free techniques (microscopy procedures that do not require sample staining) minimize interference biological foreign marking substances reduce intense light potential photo-toxicity effects. This review focuses on synergic capabilities atomic force microscopy (AFM) a well-developed robust strategy with demonstrated applications unravel intimate details in biomedical applications, label-free, fast, enduring Holotomographic Microscopy (HTM) strategy. HTM technique combines holography tomography using low intensity continuous illumination laser investigate (quantitatively non-invasively) microorganisms, thin tissue generating three-dimensional (3D) images monitoring real-time inner morphological changes. We first operating principles form basis for complementary provided these regarding surface internal information AFM, which essential complimentary several areas interaction NMs organisms. First, AFM can provide superb resolution morphology biomechanical characterization. Second, quantitative phase enable modeling quantification volume, area, protein content, mass density main components cells including microbiological systems. These result from directly quantifying refractive index changes without requiring fluorescent markers or chemicals. As such, ideal long-term organisms conditions close natural settings. present case-based principal uses both contributions nanomedicine nanotoxicology (study harmful effects organisms), emphasizing cancer infectious disease control. impact sequential provides clear drive adopting interdependent fundamental tools.

Language: Английский

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The Future of ChatGPT in Medicinal Chemistry: Harnessing AI for Accelerated Drug Discovery

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(13)

Published: March 27, 2024

Abstract Artificial Intelligence (AI) has emerged as a transformative tool in various fields, including medicinal chemistry and drug discovery. The integration of artificial intelligence machine learning (ML) technologies revolutionized discovery processes. Among AI models, ChatGPT (Generative Pre‐trained Transformer) shown remarkable capabilities natural language understanding generation. This review article delves into the potential applications prospects domain chemistry, focusing on its contributions to discovery, compound design, virtual screening, target identification, optimization pharmacokinetic properties. ChatGPT′s ability generate contextually relevant text makes it valuable for data mining analysis vast chemical biological information repositories. In this article, authors have discussed challenges ethical considerations associated with implementation 3.5 research. Authors also extend their acknowledgment (version 3.5) contribution furnishing responses prompt, thereby shedding light field chemistry. analyzed ChatGPT.

Language: Английский

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Antibacterial micro/nanomotors: advancing biofilm research to support medical applications

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 24, 2023

Abstract Multi-drug resistant (MDR) bacterial infections are gradually increasing in the global scope, causing a serious burden to patients and society. The formation of biofilms, which is one key reasons for antibiotic resistance, blocks penetration by forming physical barrier. Nano/micro motors (MNMs) micro-/nanoscale devices capable performing complex tasks microenvironment transforming various energy sources (including chemical fuels or external fields) into mechanical motion actuation. This autonomous movement provides significant advantages breaking through biological barriers accelerating drug diffusion. In recent years, MNMs with high penetrating power have been used as carriers antibiotics overcome enabling efficient delivery improving therapeutic effectiveness MDR infections. Additionally, non-antibiotic antibacterial strategies based on nanomaterials, such photothermal therapy photodynamic therapy, continuously being developed due their non-invasive nature, effectiveness, non-induction resistance. Therefore, multifunctional broad prospects treatment review discusses performance breakthrough elimination well application field anti-infection. Finally, challenges future development directions introduced.

Language: Английский

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AI-powered revolution in plant sciences: advancements, applications, and challenges for sustainable agriculture and food security

Published: Aug. 6, 2024

Artificial intelligence (AI) is revolutionizing plant sciences by enabling precise species identification, early disease diagnosis, crop yield prediction, and precision agriculture optimization. AI uses machine learning image recognition to aid ecological research biodiversity conservation. It plays a crucial role in breeding accelerating the development of resilient, high-yielding crops with desirable traits. models using climate soil data contribute sustainable food security. In phenotyping, automates measurement analysis characteristics, enhancing our understanding growth. Ongoing aims improve models’ robustness interpretability while addressing privacy algorithmic biases. Interdisciplinary collaboration essential fully harness AI’s potential for sustainable, food-secure future.

Language: Английский

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The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: Aug. 18, 2024

Abstract Over the last four decades, pharmaceutical companies’ expenditures on research and development have increased 51‐fold. During this same time, clinical success rates for new drugs remained unchanged at about 10 percent, predominantly due to lack of efficacy and/or safety concerns. This persistent problem underscores need innovate across entire drug process, particularly in formulation, which is often deprioritized under‐resourced.

Language: Английский

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