Talanta, Journal Year: 2025, Volume and Issue: 294, P. 128269 - 128269
Published: May 3, 2025
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(11)
Published: Dec. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Language: Английский
Citations
51
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677
Published: Jan. 31, 2024
Language: Английский
Citations
44
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7681 - 7741
Published: Jan. 1, 2024
This review summarizes insights into colorant selection and signal mechanisms for the development of colorimetric sensing POC sensors.
Language: Английский
Citations
37
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)
Published: March 5, 2024
Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher fidelity monitoring physiological and pathological processes than clinical visible/the fluorescence imaging. Notably, heavily dependent on agents. So far, indocyanine green, one polymethine dyes, with good biocompatibility renal clearance only dye approved by Food Drug Administration, but it shows relatively low NIR-II brightness. Importantly, tremendous efforts are devoted to synthesizing dyes for preclinically clinically. They have shown feasibility customization structure properties fulfill various needs therapy. Herein, a timely update special focus molecular design strategies fluorescent, photoacoustic, multimodal imaging, offered. Furthermore, progress sensing biomarkers even reporting drug release illustrated. Moreover, imaging-guided therapies summarized regarding chemo-, photothermal, photodynamic, approaches. In addition, artificial intelligence pointed out potential expedite development. This comprehensive review will inspire interest among wide audience offer handbook people an dyes.
Language: Английский
Citations
23
ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 17468 - 17475
Published: Aug. 21, 2023
Biological channels can rapidly and continuously modulate ion transport behaviors in response to external stimuli, which play essential roles manipulating physiological pathological processes cells. Here, mimic the biological channels, a bionic nanochannel is developed by synergizing cationic silicon-substituted rhodamine (SiRh) with glass nanopipette for transmembrane single-cell quantification. Taking fast reversible nucleophilic addition reaction between glutathione (GSH) SiRh, shows GSH, its inner-surface charges changing positive negative charges, leading distinct switch ionic current rectification (ICR). With nanochannel, spatiotemporal-resolved operation performed quantify endogenous GSH single cell, allowing monitoring of intracellular fluctuation tumor cells upon photodynamic therapy ferroptosis. Our results demonstrate that it feasible tool situ quantification cells, may be adapted addressing other biomolecules usage stimuli-responsive probes.
Language: Английский
Citations
24
Exploration, Journal Year: 2024, Volume and Issue: 4(4)
Published: Jan. 18, 2024
Molecular imaging is a non-invasive method that widely used for visualization and detection of biological events at cellular or molecular levels. Stimuli-responsive linkers can be selectively cleaved by specific biomarkers desired sites to release activate agents are appealing tools improve the specificity, sensitivity, efficacy imaging. This review summarizes recent advances stimuli-responsive their application in imaging, highlighting potential these design activatable probes. It hoped this could inspire more research interests development responsive associated applications.
Language: Английский
Citations
15
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(19), P. 13163 - 13175
Published: May 3, 2024
A pretargeted strategy that decouples targeting vectors from radionuclides has shown promise for nuclear imaging and/or therapy in vivo. However, the current approach relies on use of antibodies or nanoparticles as vectors, which may be compromised by poor tissue penetration and limited accumulation tumor tissues. Herein, we present an orthogonal dual-pretargeted combining stimuli-triggered situ self-assembly with fast inverse electron demand Diels-Alder (IEDDA) reaction strong biotin-streptavidin (SA) interaction near-infrared fluorescence (NIR FL) magnetic resonance (MR) tumors. This uses a small-molecule probe (P-Cy-TCO&Bio) containing both biotin trans-cyclooctene (TCO) tumor-targeting vector. P-Cy-TCO&Bio can efficiently penetrate subcutaneous HeLa tumors through biotin-assisted targeted delivery undergo to form biotinylated TCO-bearing (Cy-TCO&Bio NPs) cell membranes. Cy-TCO&Bio NPs exhibited "off-on" NIR FL retained tumors, offering high density TCO groups concurrent capture Gd-chelate-labeled tetrazine (Tz-Gd) IR780-labeled SA (SA-780) via IEDDA SA-biotin interaction. Moreover, offered multiple-valent binding modes toward SA, additionally regulated cross-linking Cy-Gd&Bio into microparticles (Cy-Gd&Bio/SA MPs). process could significantly (1) increase
Language: Английский
Citations
15
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Abstract The lanthanide complex, characterized by narrow emission bands, large Stokes shifts, long luminescence lifetime, robust resistance to photobleaching, and magnetic properties, affords significant promise for molecular imaging biosensing applications. While most complexes emitting visible light are extensively studied cellular‐level detection bioimaging, near‐infrared‐emitted (700–1700 nm) compounds exhibit more favorable properties bioimaging biosensing, ascribed from deeper penetration reduced bleaching effects. Besides, the complex with higher resonance signals can enhance image resolution sensitivity, offering precise analysis. However, widespread use of high‐efficiency is currently impeded lack design approaches improving sensitization chromophores extended excitation wavelengths. In this review, some fundamental theories strategies summarized imaging, lifetime‐engineered dual‐modal now highlight a selection review addresses existing gap in literature proposing feasible fluorescent properties. Concurrently, future challenges opportunities field probes discussed.
Language: Английский
Citations
12
Angewandte Chemie, Journal Year: 2023, Volume and Issue: 136(11)
Published: Dec. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Language: Английский
Citations
22
Chemical Research in Chinese Universities, Journal Year: 2024, Volume and Issue: 40(2), P. 190 - 201
Published: Feb. 8, 2024
Language: Английский
Citations
7