Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

---

Copper Active Sites in Biology

Chemical Reviews, Journal Year: 2014, Volume and Issue: 114(7), P. 3659 - 3853

Published: March 3, 2014

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTCopper Active Sites in BiologyEdward I. Solomon*, David E. Heppner, Esther M. Johnston, Jake W. Ginsbach, Jordi Cirera, Munzarin Qayyum, Matthew T. Kieber-Emmons, Christian H. Kjaergaard, Ryan G. Hadt, and Li TianView Author Information Department of Chemistry, Stanford University, Stanford, California 94305, United States*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 7, 3659–3853Publication Date (Web):March 3, 2014Publication History Received17 June 2013Published online3 March 2014Published inissue 9 April 2014https://pubs.acs.org/doi/10.1021/cr400327thttps://doi.org/10.1021/cr400327treview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views32519Altmetric-Citations1308LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copper,Crystal structure,Ligands,Peptides proteins,Redox reactions Get e-Alerts

Language: Английский

---

Exploration of the medical periodic table: towards new targets

Chemical Communications, Journal Year: 2013, Volume and Issue: 49(45), P. 5106 - 5106

Published: Jan. 1, 2013

Metallodrugs offer potential for unique mechanisms of drug action based on the choice metal, its oxidation state, types and number coordinated ligands coordination geometry. We discuss recent progress in identifying new target sites elucidating anti-cancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, anti-neurodegenerative agents, as well design metal-based diagnostic agents. Progress defining has been accelerated recently by advances proteomics, genomics metal speciation analysis. Examples compounds chelating agents (enzyme inhibitors) currently clinical use, trials or preclinical development are highlighted.

Language: Английский

---

Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

---

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(2), P. 1221 - 1322

Published: Aug. 10, 2018

Neurodegenerative diseases pose a substantial socioeconomic burden on society. Unfortunately, the aging world population and lack of effective cures foreshadow negative outlook. Although large amount research has been dedicated to elucidating pathologies neurodegenerative diseases, their principal causes remain elusive. Metal ion dyshomeostasis, proteopathy, oxidative stress, neurotransmitter deficiencies are pathological features shared across multiple disorders. In addition, these factors proposed be interrelated upon disease progression. Thus, development multifunctional compounds capable simultaneously interacting with several components suggested as solution undertake complex diseases. this review, we outline discuss possible therapeutic targets in Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis molecules, previously designed or discovered potential drug candidates for disorders emphasis multifunctionality. underrepresented areas discussed indicate new directions.

Language: Английский

---

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

European Journal of Medicinal Chemistry, Journal Year: 2018, Volume and Issue: 162, P. 679 - 734

Published: Nov. 22, 2018

Language: Английский

---

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Chemical Reviews, Journal Year: 2014, Volume and Issue: 114(13), P. 6661 - 6714

Published: June 5, 2014

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPhysicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)Francois-Xavier Theillet†, Andres Binolfi†, Tamara Frembgen-Kesner‡, Karan Hingorani§, Mohona Sarkar∥, Ciara Kyne⊥, Conggang Li#, Peter B. Crowley⊥, Lila Gierasch§, Gary J. Pielak∥, Adrian H. Elcock‡, Anne Gershenson§, Philipp Selenko*†View Author Information† Department NMR-supported Structural Biology, In-cell NMR Laboratory, Leibniz Institute Molecular Pharmacology (FMP Berlin), Robert-Roessle Strasse 10, 13125 Berlin, Germany‡ Biochemistry, University Iowa, Bowen Science Building, 51 Newton Road, Iowa City, 52242, United States§ Departments Biochemistry & Biology Chemistry, Program in Cellular Massachusetts, Amherst, 240 Thatcher Way, Massachusetts 01003, States∥ Biophysics Lineberger Comprehensive Cancer Center, North Carolina, Chapel Hill, Carolina 27599-3290, States⊥ School National Ireland, Galway, Ireland# Key Laboratory Magnetic Resonance Biological Systems, State Atomic Physics, Wuhan Center for Resonance, Physics Mathematics, Chinese Academy Sciences, Wuhan, 430071, P.R. China*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 13, 6661–6714Publication Date (Web):June 5, 2014Publication History Received9 December 2013Published online5 June 2014Published inissue 9 July 2014https://doi.org/10.1021/cr400695pCopyright © 2014 American Chemical SocietyRIGHTS PERMISSIONSACS AuthorChoiceArticle Views17541Altmetric-Citations302LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (20 MB) Get e-AlertsSUBJECTS:Aggregation,Diffusion,Fluorescence,Monomers,Peptides proteins e-Alerts

Language: Английский

---

What are heavy metals? Long-standing controversy over the scientific use of the term ‘heavy metals’ – proposal of a comprehensive definition

Toxicological & Environmental Chemistry Reviews, Journal Year: 2017, Volume and Issue: 100(1), P. 6 - 19

Published: Dec. 7, 2017

The term ‘heavy metals’ is commonly used in the environmental literature to refer metals and metalloids associated with pollution, toxicity adverse effects on biota. has been diversely defined, mostly terms of density, relative atomic mass number. This diversity definitions raised questions about nomenclature these elements. inclusion metalloid As nonmetal Se heavy also an important issue. Some people have called as meaningless, imprecise poorly defined suggested abandoning use term. itself may not be problematic but careless inconsistent terminology led a confusion meaning continued it should more comprehensive scientific way. Here, definition ‘naturally occurring having number (Z) greater than 20 elemental density 5 g cm−3.’ A screening Periodic Table according this yields 51 elements metals.’ are excluded from metals.

Language: Английский

---

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

ACS Chemical Biology, Journal Year: 2013, Volume and Issue: 8(5), P. 856 - 865

Published: March 18, 2013

Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark of AD is accumulation misfolded amyloid-β (Aβ) peptides hyperphosphorylated tau (ptau) proteins in the brain. Since etiology remains unclear, several hypotheses have emerged elucidate its pathways. amyloid cascade hypothesis, a leading hypothesis for development, advocates Aβ as principal culprit. Additionally, evidence suggests that may contribute pathology. also been shown impact each other's pathology either directly or indirectly. Furthermore, associated with these proteins. Metal interactions tau/ptau influence their aggregation properties neurotoxicity. Herein, we present current understanding on roles Aβ, tau, ions, placing equal emphasis proposed features, well inter-relationships pathogenesis.

Language: Английский

---

Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species

Proceedings of the National Academy of Sciences, Journal Year: 2013, Volume and Issue: 110(10), P. 3743 - 3748

Published: Feb. 20, 2013

Despite the significance of Alzheimer’s disease, link between metal-associated amyloid-β (metal–Aβ) and disease etiology remains unclear. To elucidate this relationship, chemical tools capable specifically targeting modulating metal–Aβ species are necessary, along with a fundamental understanding their mechanism at molecular level. Herein, we investigated compared interactions reactivities green tea extract, (−)-epigallocatechin-3-gallate [(2 R ,3 )-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2 H -1-benzopyran-3-yl 3,4,5-trihydroxybenzoate; EGCG], metal [Cu(II) Zn(II)]–Aβ metal-free Aβ species. We found that EGCG interacted formed small, unstructured aggregates more noticeably than in conditions vitro. In addition, upon incubation EGCG, toxicity presented by was mitigated living cells. understand reactivity level, structural insights were obtained ion mobility-mass spectrometry (IM-MS), 2D NMR spectroscopy, computational methods. These studies indicated ( i ) bound to monomers dimers, generating compact peptide conformations those from EGCG-untreated species; ii ternary EGCG–metal–Aβ complexes produced. Thus, demonstrate distinct antiamyloidogenic toward structure-based mechanism.

Language: Английский

---