Nano based drug delivery systems: recent developments and future prospects

Journal of Nanobiotechnology, Journal Year: 2018, Volume and Issue: 16(1)

Published: Sept. 19, 2018

Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range employed to serve as means of diagnostic tools or deliver therapeutic agents specific targeted sites controlled manner. Nanotechnology offers multiple benefits treating chronic human diseases by site-specific, target-oriented precise medicines. Recently, there number outstanding applications nanomedicine (chemotherapeutic agents, biological immunotherapeutic etc.) treatment various diseases. The current review, presents an updated summary recent advances field nanomedicines based drug through comprehensive scrutiny discovery application nanomaterials improving both efficacy novel old drugs (e.g., natural products) selective diagnosis disease marker molecules. opportunities challenges from synthetic/natural sources their clinical also discussed. In addition, we have included information regarding trends perspectives area.

Language: Английский

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Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 332, P. 312 - 336

Published: Feb. 27, 2021

Polymeric micelles, i.e. aggregation colloids formed in solution by self-assembling of amphiphilic polymers, represent an innovative tool to overcome several issues related drug administration, from the low water-solubility poor permeability across biological barriers. With respect other nanocarriers, polymeric micelles generally display smaller size, easier preparation and sterilization processes, good solubilization properties, unfortunately associated with a lower stability fluids more complicated characterization. Particularly challenging is study their interaction environment, essential predict real vivo behavior after administration. In this review, general presentation on features different characterization techniques are discussed, ones used for determination basic characteristics (critical micellar concentration, surface charge, morphology) complex approaches figure out kinetic stability, release presence substrates (fluids, cells tissues). The presented (such as dynamic light scattering, AFM, cryo-TEM, X-ray FRET, symmetrical flow field-flow fractionation (AF4) density ultracentrifugation), each one own advantages limitations, can be combined achieve deeper comprehension behavior. set-up validation adequate methods description starting point development clinical success.

Language: Английский

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PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

Applied Materials Today, Journal Year: 2018, Volume and Issue: 12, P. 177 - 190

Published: May 29, 2018

Language: Английский

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Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 327, P. 316 - 349

Published: Aug. 12, 2020

Language: Английский

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Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment

Theranostics, Journal Year: 2017, Volume and Issue: 7(3), P. 538 - 558

Published: Jan. 1, 2017

The development of traditional tumor-targeted drug delivery systems based on EPR effect and receptor-mediated endocytosis is very challenging probably because the biological complexity tumors as well limitations in design functional nano-sized systems. Recently, multistage (Ms-DDS) triggered by various specific tumor microenvironment stimuli have emerged for therapy imaging. In response to differences physiological blood circulation, microenvironment, intracellular environment, Ms-DDS can change their physicochemical properties (such size, hydrophobicity, or zeta potential) achieve deeper penetration, enhanced cellular uptake, timely release, effective endosomal escape. Based these mechanisms, could deliver maximum quantity drugs therapeutic targets including tissues, cells, subcellular organelles eventually exhibit highest efficacy. this review, we expatiate responsive modes stimuli, introduce recent advances nanoparticle systems, especially multi-stimuli discuss functions, effects, prospects.

Language: Английский

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Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 47(1), P. 28 - 52

Published: Oct. 23, 2017

Theranostic systems are receiving ever-increasing attention due to their potential therapeutic utility, imaging enhancement capability, and promise for advancing the field of personalized medicine, particularly as it relates diagnosis, staging, treatment cancer. In this Tutorial Review, we provide an introduction concepts theranostic drug delivery effected via use conjugates that able target cancer cells selectively, cytotoxic chemotherapeutics, produce readily monitored signals in vitro vivo. The underlying design concepts, requiring synthesis composed reporters, masked chemotherapeutic drugs, cleavable linkers, targeting ligands, discussed. Particular emphasis is placed on highlighting benefits fluorogenic reaction-based targeted activated both therapy by cellular entities, e.g., thiols, reactive oxygen species enzymes, which present at relatively elevated levels tumour environments, physiological characteristics cancer, hypoxia acidic pH. Also discussed external stimulus, such light. work summarized Review will help define role reaction-based, cancer-targeting theranostics may have discovery efforts, well improving our understanding uptake release mechanisms.

Language: Английский

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Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy

Advanced Science, Journal Year: 2021, Volume and Issue: 9(1)

Published: Nov. 19, 2021

Abstract The past decades have witnessed great progress in cancer immunotherapy, which has profoundly revolutionized oncology, whereas low patient response rates and potential immune‐related adverse events remain major clinical challenges. With the advantages of controlled delivery modular flexibility, nanomedicine offered opportunities to strengthen antitumor immune responses sensitize tumor immunotherapy. Furthermore, tumor‐microenvironment (TME)‐responsive been demonstrated achieve specific localized amplification tissue a safe effective manner, increasing immunotherapy reducing side effects simultaneously. Here, recent TME‐responsive for is summarized, responds signals TME, such as weak acidity, reductive environment, high‐level reactive oxygen species, hypoxia, overexpressed enzymes, adenosine triphosphate. Moreover, combine nanomedicine‐based therapy immunotherapeutic strategies overcome each step cancer‐immunity cycle enhance discussed. Finally, existing challenges further perspectives this rising field with hope improved development applications are

Language: Английский

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Evolution of macromolecular complexity in drug delivery systems

Nature Reviews Chemistry, Journal Year: 2017, Volume and Issue: 1(8)

Published: Aug. 9, 2017

Language: Английский

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Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

Small, Journal Year: 2019, Volume and Issue: 15(45)

Published: Oct. 10, 2019

Abstract Engineering of smart photoactivated nanomaterials for targeted drug delivery systems (DDS) has recently attracted considerable research interest as light enables precise and accurate controlled release molecules in specific diseased cells and/or tissues a highly spatial temporal manner. In general, the development appropriate light‐triggered DDS relies on processes photolysis, photoisomerization, photo‐cross‐linking/un‐cross‐linking, photoreduction, which are normally sensitive to ultraviolet (UV) or visible (Vis) irradiation. Considering issues poor tissue penetration high phototoxicity these high‐energy photons UV/Vis light, nanocarriers have been developed based light‐response low‐energy photon irradiation, particular wavelengths located near infrared (NIR) range. NIR achieved by using two‐photon absorption upconversion processes. Herein, recent advances light‐responsive nanoplatforms reviewed, covering mechanism responsive small polymers, UV Vis nanocarriers, nanocarriers. NIR‐light triggered excitation luminescence strategies is also included. addition, challenges future perspectives highlighted.

Language: Английский

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Disulfide-Based Multifunctional Conjugates for Targeted Theranostic Drug Delivery

Accounts of Chemical Research, Journal Year: 2015, Volume and Issue: 48(11), P. 2935 - 2946

Published: Oct. 29, 2015

Theranostics, chemical entities designed to combine therapeutic effects and imaging capability within one molecular system, have received considerable attention in recent years. Much of this interest reflects the promise inherent personalized medicine, including disease-targeted treatments for cancer patients. One important approach realizing latter involves development so-called theranostic conjugates, multicomponent constructs that selectively target cells deliver cytotoxic agents while producing a readily detectable signal can be monitored both vitro vivo. This requires synthesis relatively complex systems comprising reporters, masked chemotherapeutic drugs, cleavable linkers, targeting ligands. Ideally, cleavage process should take place or near activated by cellular components are associated with states specifically expressed at higher level cells. Among linkers currently being explored construction such localizing disulfide bonds particularly attractive. is because stable most blood pools but efficiently cleaved thiols, glutathione (GSH) thioredoxin (Trx), which generally found elevated levels tumors. When linked fluorophores, changes emission intensity shifts maxima typically seen upon as result perturbations internal charge transfer (ICT) processes. In well-designed systems, allows facile imaging. Account, we summarize our studies involving disulfide-based fluorescent drug delivery preliminary tests their biological utility To date, variety agents, doxorubicin, gemcitabine, camptothecin, been used create number naphthalimide, coumarin, BODIPY, rhodol, Cy7. The resulting core (drug-disulfide-fluorophore) further any several site-localizing entities, galactose, folate, biotin, RGD (Arg-Gly-Asp) peptide sequence, an intrinsic selectivity over normal Site-specific endogenous thiols serves release produce easy-to-monitor change fluorescence signature cell. On basis results summarized propose cancer-targeting theranostics may role play advancing discovery efforts, well improving understanding uptake mechanisms.

Language: Английский

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