Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Oct. 20, 2023
Abstract
Insufficient
drug
loading
and
leakage
of
payload
remain
major
challenges
in
designing
liposome-based
delivery
systems.
These
phenomena
can
limit
duration
effect
cause
toxicity.
Targeting
the
rate-limiting
step
release
from
liposomes,
we
modify
(aromatized)
them
to
have
aromatic
groups
within
their
lipid
bilayers.
Aromatized
liposomes
are
designed
with
synthetic
phospholipids
covalently
conjugated
onto
acyl
chains.
The
optimized
aromatized
liposome
increases
significantly
decreases
burst
a
broad
range
payloads
(small
molecules
macromolecules,
different
degrees
hydrophilicity)
extends
release.
encapsulating
anesthetic
tetrodotoxin
(TTX)
achieve
markedly
prolonged
decreased
toxicity
an
application
where
used
clinically:
local
anesthesia,
even
though
TTX
is
hydrophilic
small
molecule
which
typically
difficult
encapsulate.
Aromatization
bilayers
improve
performance
liposomal
Saudi Pharmaceutical Journal,
Journal Year:
2017,
Volume and Issue:
26(1), P. 64 - 70
Published: Oct. 25, 2017
The
development
of
nanoparticle-based
drug
formulations
has
yielded
the
opportunities
to
address
and
treat
challenging
diseases.
Nanoparticles
vary
in
size
but
are
generally
ranging
from
100
500
nm.
Through
manipulation
size,
surface
characteristics
material
used,
nanoparticles
can
be
developed
into
smart
systems,
encasing
therapeutic
imaging
agents
as
well
bearing
stealth
property.
Further,
these
systems
deliver
specific
tissues
provide
controlled
release
therapy.
This
targeted
sustained
delivery
decreases
related
toxicity
increase
patient's
compliance
with
less
frequent
dosing.
Nanotechnology
proven
beneficial
treatment
cancer,
AIDS
many
other
disease,
also
providing
advancement
diagnostic
testing.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(29)
Published: May 7, 2018
Abstract
Advances
in
biomaterials
for
drug
delivery
are
enabling
significant
progress
biology
and
medicine.
Multidisciplinary
collaborations
between
physical
scientists,
engineers,
biologists,
clinicians
generate
innovative
strategies
materials
to
treat
a
range
of
diseases.
Specifically,
recent
advances
include
major
breakthroughs
cancer
immunotherapy,
autoimmune
diseases,
genome
editing.
Here,
the
design
implementation
reviewed.
A
brief
history
field
is
first
established,
then
commentary
on
RNA
delivery,
responsive
development,
immunomodulation
provided.
Current
challenges
associated
with
these
areas
as
well
opportunities
address
long‐standing
problems
medicine
discussed
throughout.
Polymers,
Journal Year:
2020,
Volume and Issue:
12(4), P. 920 - 920
Published: April 15, 2020
The
success
of
oil-based
plastics
and
the
continued
growth
production
utilisation
can
be
attributed
to
their
cost,
durability,
strength
weight
ratio,
eight
contributions
ease
everyday
life.
However,
mainly
single
use,
durability
recalcitrant
nature
have
led
a
substantial
increase
as
fraction
municipal
solid
waste.
need
substitute
use
products
that
are
not
easy
collect
has
inspired
lot
research
towards
finding
sustainable
replacements
for
plastics.
In
addition,
specific
physicochemical,
biological,
degradation
properties
biodegradable
polymers
made
them
attractive
materials
biomedical
applications.
This
review
summarises
advances
in
drug
delivery
systems,
specifically
design
nanoparticles
based
on
polymers.
We
also
discuss
performed
area
biophotonics
challenges
opportunities
brought
by
application
tissue
engineering.
then
state-of-the-art
packaging
emphasise
smart
development.
Finally,
we
provide
an
overview
biodegradation
these
composites
managed
unmanaged
environments.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(6), P. 2768 - 2794
Published: Jan. 22, 2020
Abstract
Calixarenes
(CAs),
representing
the
third
generation
of
supramolecular
hosts
and
one
most
widely
studied
macrocyclic
scaffolds,
offer
(almost)
unlimited
structure
application
possibilities
due
to
their
ease
modification,
which
allows
establish
a
large
molecular
library
as
material
basis
for
diverse
biomedical
applications.
Moreover,
CAs
derivatives
engage
in
various
noncovalent
interactions
facile
recognition
guests
including
bioactive
molecules
are
also
important
building
blocks
fabrication
architectures.
In
view
self‐assembly
properties,
extensively
applied
biosensing,
bioimaging,
drug/gene
delivery.
Additionally,
some
CA
exhibit
biological
activities
can
therefore
be
used
new
therapeutic
agents.
Herein,
we
summarize
applications
vitro
diagnosis
(biosensing),
vivo
(bioimaging),
therapy.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
