Assessing Atropisomer Axial Chirality in Drug Discovery and Development

Journal of Medicinal Chemistry, Journal Year: 2011, Volume and Issue: 54(20), P. 7005 - 7022

Published: Aug. 17, 2011

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTAssessing Atropisomer Axial Chirality in Drug Discovery and DevelopmentSteven R. LaPlante*†, Lee D. Fader†, Keith Fandrick‡, Daniel Oliver Hucke†, Ray Kemper‡, Stephen P. F. Miller§, Paul J. Edwards*†View Author Information† Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Quebec, H7S 2G5, Canada‡ Chemical Development, Non-Clinical Safety, Pharmaceutical Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States§ Office New Quality Assessment, Center for Evaluation Research, U.S. Food Administration, 10903 Hampshire Avenue, Building 22, Room 1446, Silver Spring, Maryland 20993, States*For S.R.L.: phone, 1-450-682-4640; fax, 1-450-682-8434; e-mail, [email protected]. For P.J.E.: protected]Cite this: Med. Chem. 2011, 54, 20, 7005–7022Publication Date (Web):August 17, 2011Publication History Received10 May 2011Published online15 September inissue 27 October 2011https://pubs.acs.org/doi/10.1021/jm200584ghttps://doi.org/10.1021/jm200584greview-articleACS PublicationsCopyright © 2011 American SocietyRequest reuse permissionsArticle Views17317Altmetric-Citations577LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chirality,Drug discovery,Mixtures,Molecular structure,Pharmaceuticals Get e-Alerts

Language: Английский

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Emerging organic contaminants in surface water and groundwater: A first overview of the situation in Italy

The Science of The Total Environment, Journal Year: 2014, Volume and Issue: 481, P. 280 - 295

Published: March 4, 2014

Language: Английский

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Environmental Mass Spectrometry: Emerging Contaminants and Current Issues

Analytical Chemistry, Journal Year: 2011, Volume and Issue: 84(2), P. 747 - 778

Published: Dec. 6, 2011

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTEnvironmental Mass Spectrometry: Emerging Contaminants and Current IssuesSusan D. RichardsonView Author Information National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, Georgia 30605, United StatesCite this: Anal. Chem. 2012, 84, 2, 747–778Publication Date (Web):December 6, 2011Publication History Published online6 December 2011Published inissue 17 January 2012https://pubs.acs.org/doi/10.1021/ac202903dhttps://doi.org/10.1021/ac202903dreview-articleACS PublicationsCopyright © This article not subject to Copyright. 2011 by the American Chemical SocietyRequest reuse permissionsArticle Views10520Altmetric-Citations269LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum of full text downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chlorine,Drinking water,Impurities,Pharmaceuticals,Wastewater Get e-Alerts

Language: Английский

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Emerging environmental contaminants: Challenges facing our next generation and potential engineering solutions

Environmental Technology & Innovation, Journal Year: 2017, Volume and Issue: 8, P. 40 - 56

Published: April 17, 2017

Language: Английский

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Fate of estrogenic hormones in wastewater and sludge treatment: A review of properties and analytical detection techniques in sludge matrix

Water Research, Journal Year: 2012, Volume and Issue: 46(18), P. 5813 - 5833

Published: Aug. 17, 2012

Language: Английский

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Endocrine Disruptors in Water and Their Effects on the Reproductive System

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(6), P. 1929 - 1929

Published: March 12, 2020

Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known be endocrine disrupting chemicals (EDCs). EDCs impact the system and subsequently impair development fertility non-human animals humans. The source chemical contamination is diverse, originating from byproducts formed during disinfection processes, release industry livestock activity, or therapeutic drugs released into sewage. This review discusses occurrence such as byproducts, fluorinated compounds, bisphenol A, phthalates, pesticides, estrogens, it outlines their adverse effects

Language: Английский

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Endocrine disrupting chemicals and sexual behaviors in fish – a critical review on effects and possible consequences

Critical Reviews in Toxicology, Journal Year: 2012, Volume and Issue: 42(8), P. 653 - 668

Published: June 15, 2012

Endocrine disrupting chemicals (EDCs) enter aquatic ecosystems through discharged effluents, mainly from wastewater treatment works and diffuse run off land, affect a wide range of biota, including fish. Evidence for altered physiology in fish as consequence endocrine disruption is global, with some the most widely reported effects on sexual development function. In recent years, research has shown that behaviors can also be affected by EDCs which potentially implications individual fitness population level outcomes. This review presents critical assessment behavior fish, focusing associated reproduction. We investigate commonalities differences between species commonly applied ecotoxicology, drawing out common principles impacts then reviewing evidence for, of, disruptions these after exposures to EDCs. an analysis exposure estrogen ethinylestradiol, we show life-stage at key factor determining behavioral responses populations. EDC-induced changes occur similar concentrations established biomarker (e.g. vitellogenin induction estrogens), indicating equally sensitive (and noninvasive) indicator EDC exposure. Adopting indicators chemical effects, however, still many technical interpretation challenges there very little information available how under laboratory conditions equate those occurring wild

Language: Английский

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Monitoring, sources, receptors, and control measures for three European Union watch list substances of emerging concern in receiving waters – A 20 year systematic review

The Science of The Total Environment, Journal Year: 2016, Volume and Issue: 574, P. 1140 - 1163

Published: Oct. 14, 2016

Language: Английский

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Occurrence, fate and environmental risk assessment of endocrine disrupting compounds at the wastewater treatment works in Pietermaritzburg (South Africa)

The Science of The Total Environment, Journal Year: 2013, Volume and Issue: 468-469, P. 584 - 597

Published: Sept. 20, 2013

Language: Английский

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Ethinyl Estradiol and Other Human Pharmaceutical Estrogens in the Aquatic Environment: A Review of Recent Risk Assessment Data

The AAPS Journal, Journal Year: 2014, Volume and Issue: 16(2), P. 299 - 310

Published: Jan. 27, 2014

Language: Английский

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