Reproductive endocrine disruption in smallmouth bass (Micropterus dolomieu) in the Potomac River basin: spatial and temporal comparisons of biological effects

Environmental Monitoring and Assessment, Journal Year: 2011, Volume and Issue: 184(7), P. 4309 - 4334

Published: Aug. 3, 2011

A high prevalence of intersex or testicular oocytes (TO) in male smallmouth bass within the Potomac River drainage has raised concerns as to health river. Studies were conducted document biomarker responses both temporally and spatially better understand influence normal physiological cycles, well water quality land-use influences. Smallmouth collected over a 2-year period from three tributaries River: Shenandoah River, South Branch Conococheague Creek, an out-of-basin reference site on Gauley River. The TO varied seasonally with lowest observed July, post-spawn. Reproductive maturity and/or lack spawning previous spring, practices such application manure pesticides, may seasonal observations. Annual, seasonal, differences also percentage males measurable concentrations plasma vitellogenin, mean concentration vitellogenin females, 17β-estradiol testosterone sexes. Bass (moderate TO) had less sperm per testes mass lower those being motile when compared (low TO). An inverse relationship was noted between severity motility. association wastewater treatment plant flow, percent agriculture, total number animal feeding operations, poultry houses, density catchment observed.

Language: Английский

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Environmental Designer Drugs: When Transformation May Not Eliminate Risk

Environmental Science & Technology, Journal Year: 2014, Volume and Issue: 48(20), P. 11737 - 11745

Published: Oct. 2, 2014

ADVERTISEMENT RETURN TO ISSUEFeatureNEXTEnvironmental Designer Drugs: When Transformation May Not Eliminate RiskDavid M. Cwiertny*†, Shane A. Snyder‡§, Daniel Schlenk∥, and Edward P. Kolodziej*⊥#View Author Information† Civil Environmental Engineering, University of Iowa, 4105 Seamans Center, Iowa City, 52242, United States‡ Chemical Arizona, 1133 E. James Rogers Way, Tucson, Arizona 85721, States§ NUS Research Institute (NERI), National Singapore, 5A Engineering Drive 1, T-Lab Building, Singapore 117411∥ Department Sciences, California, Riverside, California 92521, States⊥ Interdisciplinary Arts Washington, Tacoma, 1900 Commerce Street, Washington 98402, States# 201 More Hall, Seattle, 98195, States*(D.M.C.) Phone: +1-319-335-1401; fax: +1-319-335-5660; e-mail: [email protected]*(E.P.K.) +1-253-692-5659; +1-253-692-5718; protected]Cite this: Environ. Sci. Technol. 2014, 48, 20, 11737–11745Publication Date (Web):September 12, 2014Publication History Published online2 October 2014Published inissue 21 2014https://doi.org/10.1021/es503425wCopyright © 2014 American SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views17733Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (2 MB) Get e-AlertsSUBJECTS:Bioactivity,Impurities,Physical chemical processes,Receptors,Steroids e-Alerts

Language: Английский

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Life Histories, Salinity Zones, and Sublethal Contributions of Contaminants to Pelagic Fish Declines Illustrated with a Case Study of San Francisco Estuary, California, USA

Estuaries and Coasts, Journal Year: 2011, Volume and Issue: 35(2), P. 603 - 621

Published: Nov. 22, 2011

Language: Английский

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Identification and Environmental Implications of Photo-Transformation Products of Trenbolone Acetate Metabolites

Environmental Science & Technology, Journal Year: 2013, Volume and Issue: 47(10), P. 5031 - 5041

Published: April 18, 2013

Despite the widespread use of anabolic androgen trenbolone acetate (TBA) in animal agriculture, evidence demonstrating occurrence TBA metabolites such as 17β-trenbolone (17β-TBOH), 17α-trenbolone (17α-TBOH), and trendione (TBO) is relatively scarce, potentially due to rapid transformation processes direct photolysis. Therefore, we investigated phototransformation associated ecological implications by characterizing photoproducts arising from photolysis 17β-TBOH, 17α-TBOH, TBO their ecotoxicity. LC-HRMS/MS analysis identified a range hydroxylated products that were no longer photoactive, with primary consisting monohydroxy species presumptive diastereomers. Also observed higher-order probably formed via subsequent reaction photoproducts. NMR confirmed formation 12,17-dihydroxy-estra-5(10),9(11),dien-3-one (12-hydroxy-TBOH; 2.2 mg), 10,12,17-trihydroxy-estra-4,9(11),dien-3-one (10,12-dihydroxy-TBOH; 0.7 ring-opened 11,12-dialdehyde oxidation product (TBOH-11,12-dialdehyde; 1.0 mg) after irradiation ∼14 mg 17β-trenbolone. Though unconfirmed NMR, our data suggest additional isomeric may occur, likely reactivity unique 4,9,11 conjugated triene structure trenbolone. In vivo exposure studies employing Japanese medaka (Oryzias latipes) indicate low concentrations 17α-TBOH photoproduct mixtures can alter ovarian follicular development, whole-body 17β-estradiol levels. yields strong structural similarity parent steroids, these still retain enough biological activity elicit observable changes endocrine function at trace concentrations. These environmental do not necessarily reduce steroid hormone

Language: Английский

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Reconstitution Studies of Pesticides and Surfactants Exploring the Cause of Estrogenic Activity Observed in Surface Waters of the San Francisco Bay Delta

Environmental Science & Technology, Journal Year: 2012, Volume and Issue: 46(16), P. 9106 - 9111

Published: Aug. 10, 2012

To evaluate the potential role of endocrine disruption in decline pelagic fishes San Francisco Bay Delta California, various surface water samples were collected, extracted, and found to elicit estrogenic activity laboratory fish. Chemical analysis indicated 2 pesticides (bifenthrin, diuron), alkyphenols (AP), mixtures types alkyphenol polyethoxylates (APEOs). Evaluation was further characterized by vitro bioassays using rainbow trout hepatocytes (Oncorhynchus mykiss) vivo studies with Japanese medaka (Oryzias latipes). In bioassays, exposed alone or combination AP/APEO at concentrations observed waters failed show (induction vitelloginin mRNA). individual did not have elevated VTG ambient concentrations. However, when combined AP/APEOs 7-day exposure a significant increase observed. Exposure 5-fold higher concentration mixture also significantly induced VTG. contrast earlier permethrin, biotransformation bifenthrin metabolites liver microsomes cytochrome P450 treatment. These results showed that different modes action environmentally relevant may be associated measured extracts feral fish been shown population Delta.

Language: Английский

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Scaling Up Endocrine Disruption Effects from Individuals to Populations: Outcomes Depend on How Many Males a Population Needs

Environmental Science & Technology, Journal Year: 2017, Volume and Issue: 51(3), P. 1802 - 1810

Published: Jan. 9, 2017

Assessing how endocrine disrupting compounds (EDCs) affect population dynamics requires tracking males and females (and sex-reversed individuals) separately. A key component in any sex-specific model is the "mating function" (the relationship between sex ratio reproductive success) but this not known for fish species. Using a model, we found that EDC effects on populations strongly depend upon shape of mating function. Additionally, masculinization generally more detrimental to than feminization. We then quantified function inland silverside (Menidia beryllina), used those results assess status wild populations. Contrary expectation few can spawn with many females, silversides exhibited nearly linear This implies small changes will reduce success. Four out five ratios far from 50:50 thus are predicted be experiencing declines. Our suggest managers should place emphasis mitigating masculinizing rather feminizing effects. However, species function, such as Menidia, feminization equally detrimental.

Language: Английский

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Stereoselective Biotransformation of Permethrin to Estrogenic Metabolites in Fish

Chemical Research in Toxicology, Journal Year: 2010, Volume and Issue: 23(10), P. 1568 - 1575

Published: Sept. 13, 2010

This study investigated the stereoselective biotransformation and resulting estrogenic activity of pyrethroid insecticide, permethrin (PM). Results both in vivo (male Japanese medaka, vitellogenin (VTG) protein plasma) vitro (primary rainbow trout hepatocyte VTG-mRNA expression) assays indicated PM. 1S-cis-PM was observed to have significantly higher (P ≤ 0.05) than 1R-cis enantiomer evaluations. All enantiomers PM were oxidized a 4′-hydoxy (4OH PM) metabolite underwent esterase cleavage 3-phenoxybenzyl alcohol (3-PBOH) 3-(4′-hydroxyphenoxy)-benzyl alcohol) (3,4′-PBOH). Racemic 4OH as well 3-PBOH, 3,4′-PBOH possessed significant estrogenicity. 1S-trans-PM more extensively corresponding 1R-trans-PM. Inhibition studies with ketoconazole confirmed cytochrome P450-catalyzed hydroxylation for all stereoisomers. These stereoselectivity from parent compound metabolites.

Language: Английский

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From ‘Omics to Otoliths: Responses of an Estuarine Fish to Endocrine Disrupting Compounds across Biological Scales

PLoS ONE, Journal Year: 2013, Volume and Issue: 8(9), P. e74251 - e74251

Published: Sept. 25, 2013

Endocrine disrupting chemicals (EDCs) cause physiological abnormalities and population decline in fishes. However, few studies have linked environmental EDC exposures with responses at multiple tiers of the biological hierarchy, including population-level effects. To this end, we undertook a four-tiered investigation impacted San Francisco Bay estuary Mississippi silverside (Menidia audens), small pelagic fish. This approach demonstrated links between different sources fish levels organization. First determined that water from study site primarily by ranch run-off had only estrogenic activity vitro, while sampled receiving combination urban, limited run-off, treated wastewater effluent both androgenic activity. Secondly, molecular level found higher mRNA for estrogen-responsive genes where was detected but relatively lower expression EDCs were detected. Thirdly, organism level, males exposed to estrogens androgens significantly mean gonadal somatic indices, incidence severe testicular necrosis altered growth relative Finally, sex ratio skewed towards measured Our results suggest mixtures antagonistic potentially additive effects depending on scale being assessed, containing may produce unexpected In summary, evaluating response is necessary determine source disruption (lowest scale, i.e. cell line) what ecological impact will be (largest ratio).

Language: Английский

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Investigation of 10 Herbicides in Surface Waters of a Horticultural Production Catchment in Southeastern Australia

Archives of Environmental Contamination and Toxicology, Journal Year: 2014, Volume and Issue: 67(3), P. 358 - 373

Published: June 17, 2014

Language: Английский

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Contaminant Effects on California Bay–Delta Species and Human Health

San Francisco Estuary and Watershed Science, Journal Year: 2016, Volume and Issue: 14(4)

Published: Dec. 28, 2016

Many contaminants in the California Bay–Delta (Bay–Delta) exceed regulatory standards, affect aquatic species, and potentially human health. Recent studies provide multiple lines of evidence that species concern (e.g., decline several important fish referred to as “Pelagic Organism Decline” or POD). Contaminants occur dynamic complex mixtures exert effects at levels biological organization. Multiple chemicals impair processes cellular physiological (measured growth, development, behavior abnormalities), when viability reproductive output are affected, populations affected. As an example, population endangered Delta Smelt (Hypomesus transpacificus) is significantly associated with stressors, including insecticide use. New analyses presented this paper show significant correlations between pyrethroid use declining abundance POD species. Water sampled from causes deleterious fish, collected exhibit contaminant effects. Fish prey items also affected by contaminants; may have indirect effect on their populations. Co-occurrence thermal changes disease can exacerbate pose threats health via consumption shellfish, drinking water, contact recreation, particular, mercury, cyanobacteria toxins, disinfection byproducts, pathogens, pesticides, pharmaceuticals personal care products. The role difficult accurately assess a complex, system. However, tools approaches available evaluate separate stressors. Integrated monitoring focused mechanistic instrumental for addressing management needs. Effect risk assessments should be conducted different across life stages, emphasis early stages high-priority

Language: Английский

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