The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5086 - 5125

Published: Jan. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Language: Английский

---

Supramolecular cancer nanotheranostics

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(4), P. 2839 - 2891

Published: Jan. 1, 2021

Supramolecular cancer nanotheranostics have shown promising potentials in early-stage diagnosis and personal therapy. Herein, we summarize the progress of supramolecular provide guidance for designing new targeted theranostic agents.

Language: Английский

---

Nature‐Inspired Construction of MOF@COF Nanozyme with Active Sites in Tailored Microenvironment and Pseudopodia‐Like Surface for Enhanced Bacterial Inhibition

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(7), P. 3469 - 3474

Published: Oct. 29, 2020

Abstract Metal–organic frameworks (MOFs) have sparked increasing interest in mimicking the structure and function of natural enzymes. However, their catalytic therapeutic efficiency are unsatisfactory due to relatively lower activity. Herein, inspired by nature, a MOF@COF nanozyme has been designed as high‐efficiency peroxidase mimic, with metallic nodes MOFs active centres, hierarchical nanocavities produced growth covalent organic (COFs) binding pockets form tailored pore microenvironment around sites for enriching activating substrate molecules, perform enhanced bacterial inhibition. Furthermore, pseudopodia‐like surface COFs “skin” enabled system catch bacteria effectively further amplifying MOF‐based nanozyme. We believe that present study will not only facilitate design novel nanozymes, but also broaden biological usage MOF/COF‐based hybrid materials.

Language: Английский

---

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1188 - 1218

Published: Dec. 7, 2020

We review the general principle of design and functional modulation nanoscaled MOF heterostructures, biomedical applications in enhanced therapy.

Language: Английский

---

Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Materials Today, Journal Year: 2021, Volume and Issue: 44, P. 211 - 228

Published: Jan. 14, 2021

Language: Английский

---

Upconverted Metal–Organic Framework Janus Architecture for Near-Infrared and Ultrasound Co-Enhanced High Performance Tumor Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(7), P. 12342 - 12357

Published: June 23, 2021

Strict conditions such as hypoxia, overexpression of glutathione (GSH), and high concentration hydrogen peroxide (H2O2) in the tumor microenvironment (TME) limit therapeutic effects reactive oxygen species (ROS) for photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT). Here we fabricated a biocatalytic Janus nanocomposite (denoted UPFB) ultrasound (US) driven SDT 808 nm near-infrared (NIR) light mediated PDT by combining core-shell-shell upconversion nanoparticles (UCNPs, NaYF4:20%Yb,1%Tm@NaYF4:10%Yb@NaNdF4) ferric zirconium porphyrin metal organic framework [PCN-224(Fe)]. Our design not only substantially overcomes inefficient effect arising from inadequate Förster resonance energy transfer (FRET) process UCNPs (donor) to MOFs (acceptor) with NIR laser irradiation, but also promotes ROS generation via GSH depletion supply contributed Fe3+ ions coordinated UPFB catalase-like nanozyme. Additionally, converted Fe2+ foregoing can achieve CDT performance under acidic conditions, lysosomes. Meanwhile, linked biotin exhibits good targeting ability rapidly accumulate region, verified fluorescence imaging T2-weighted magnetic (MRI). In word, it is believed that synthesis antitumor detection heterostructures render them suitable application cancer therapeutics.

Language: Английский

---

Metal–Organic Frameworks Enhance Biomimetic Cascade Catalysis for Biosensing

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 23, 2021

Abstract Multiple enzymes‐induced biological cascade catalysis guides efficient and selective substrate transformations in vivo. The biomimetic systems, as ingenious strategies for signal transduction amplification, have a wide range of applications biosensing. However, the fragile nature enzymes greatly limits their applications. In this regard, metal–organic frameworks (MOFs) with porous structures, unique nano/microenvironments, good biocompatibility been skillfully used carriers to immobilize shielding them against hash surroundings improving catalytic efficiency. For another, nanomaterials enzyme‐like properties brilliant stabilities (nanozymes), widely applied ameliorate low stability enzymes. Inheriting abovementioned merits MOFs, performances MOFs‐immboilized nanozymes could be significantly enhanced. Furthermore, addition carriers, some MOFs can also serve nanozymes, expanding systems. Herein, recent advances fabrication MOFs‐involving enzymes/nanozymes systems biosensing are highlighted. Integrating diversified output modes, including colorimetry, electrochemistry, fluorescence, chemiluminescence, surface‐enhanced Raman scattering, sensitive detection various targets (including molecules, environmental pollutants, enzyme activities, so on) realized. Finally, challenges opportunities about further constructions reaction briefly put forward.

Language: Английский

---

Acceptor Engineering for Optimized ROS Generation Facilitates Reprogramming Macrophages to M1 Phenotype in Photodynamic Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(10), P. 5386 - 5393

Published: Nov. 25, 2020

Reprogramming tumor-associated macrophages to an antitumor M1 phenotype by photodynamic therapy is a promising strategy overcome the immunosuppression of tumor microenvironment for boosted immunotherapy. However, it remains unclear how reactive oxygen species (ROS) generated from type I and II mechanisms, relate macrophage polarization efficacy. Herein, we design synthesize three donor-acceptor structured photosensitizers with varied ROS-generating efficiencies. Surprisingly, discovered that extracellular ROS mechanism are mainly responsible reprogramming pro-tumor (M2) anti-tumor state (M1). In vivo experiments prove photosensitizer can trigger immunotherapy effective suppression growth, while therapeutic outcome abolished depleted macrophages. Overall, our highlights designing guideline macrophage-activatable photosensitizers.

Language: Английский

---

Lanthanide-Activated Nanoparticles: A Toolbox for Bioimaging, Therapeutics, and Neuromodulation

Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(11), P. 2692 - 2704

Published: Oct. 26, 2020

ConspectusOwing to their unique features, the past decade has witnessed rapid developments of lanthanide-activated nanoparticles for biological applications. These include highly tunable upconverting and downshifting photoluminescence when illuminated in deep tissue, excellent photostability against blinking bleaching effects, biocompatibility through versatile surface modification, ease achieving multifunctionality, as well satisfactory signal output. attributes make lanthanide-doped an ideal toolbox advanced bioimaging next-generation therapeutics.The interest biomedical research arises from optical properties response deep-tissue-penetrable light sources. Upon near-infrared irradiation, these with properly doped emitters display photon upconversion large anti-Stokes shifts broad-spectrum tunability ultraviolet visible. It is also possible achieve orthogonal variations wavelength lifetime. Coupled ligands, dyes, biomolecules, or other types functional nanomaterials, offer new opportunities applications bioimaging, oncotherapy, neuromodulation. Given possibility locating luminescence at "biological transmission windows", exquisite design enables deep-tissue imaging high spatial resolution. In addition, can respond high-energy photons, such X-rays, trigger nonradioactive radiative pathways, making it develop high-sensitivity X-ray detectors. Precise control paramagnetic lanthanide ions nanocrystal lattices provides materials high-performance magnetic resonance medical diagnostics research. Full consideration fundamental will facilitate multifunctional sensitive probes improve diagnostic therapeutic outcomes.In this Account, we categorize various lanthanide-activation strategies into three modes: excitation, field stimulation. We introduce energy manipulations upconverting, downshifting, persistence spectral time domains discuss how they be applied practices. assess general principles nanosystems multiple modalities review current state-of-the-art lanthanide-based theranostic nanoplatforms, particular emphasis on conversion nano-/biointerfacing emerging bioapplications. context, highlight recent advances controlling nanoplatforms single- multimodal stimulus-responsive phototherapy, optogenetics. Finally, future challenges exciting field.

Language: Английский

---

Nanoplatform-based cascade engineering for cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(24), P. 9057 - 9094

Published: Jan. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Language: Английский

---