Regenerative Biomaterials,
Journal Year:
2023,
Volume and Issue:
11
Published: Dec. 23, 2023
Abstract
Metal–organic
frameworks
(MOFs)
have
a
high
specific
surface
area,
adjustable
pores
and
can
be
used
to
obtain
functional
porous
materials
with
diverse
well-ordered
structures
through
coordination
self-assembly,
which
has
intrigued
wide
interest
in
broad
range
of
disciplines.
In
the
arena
biomedical
engineering,
functionalized
modification
MOFs
produced
drug
carriers
excellent
dispersion
functionalities
such
as
target
delivery
response
release,
promising
applications
bio-detection,
disease
therapy,
tissue
healing,
other
areas.
This
review
summarizes
present
state
research
on
functionalization
by
physical
binding
or
chemical
cross-linking
small
molecules,
polymers,
biomacromolecules,
hydrogels
evaluates
role
approach
boosting
reactivity
materials.
On
this
basis,
application
composites
engineering
fields
delivery,
repair,
treatment,
bio-detection
imaging
is
surveyed,
development
trend
prospects
an
important
new
class
field
are
anticipated,
may
provide
some
inspiration
reference
for
further
MOF
bio-medical
applications.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(15), P. 8825 - 9014
Published: July 25, 2024
Luminescence
imaging
is
a
powerful
and
versatile
technique
for
investigating
cell
physiology
pathology
in
living
systems,
making
significant
contributions
to
life
science
research
clinical
diagnosis.
In
recent
years,
luminescent
transition
metal
complexes
have
gained
attention
diagnostic
therapeutic
applications
due
their
unique
photophysical
photochemical
properties.
this
Review,
we
provide
comprehensive
overview
of
the
development
bioimaging
biosensing
applications,
with
focus
on
centers
d
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(2)
Published: Jan. 4, 2024
Abstract
The
development
of
efficient
drug
delivery
systems
is
essential
for
improving
the
efficacy
and
safety
cancer
drugs,
particularly
aggressive
difficult‐to‐treat
cancers.
Covalent
organic
frameworks
(COFs)
are
emerging
as
innovative
porous
nanomaterials
in
(DDS),
due
to
their
unique
properties,
including
metal‐free
skeleton,
predetermined
structures
pore
geometries,
high
porosity,
large
surface
area,
facile
modification
potential,
good
biocompatibility.
These
characteristics
make
COFs
excellent
candidates
by
enhancing
loading
capacity
enabling
precise
encapsulation.
This
review
emphasizes
importance
donor‐acceptor‐based
COFs,
which
provide
channels
charge
transportation,
we
also
explore
how
π‐conjugated
skeleton
enhances
its
long‐acting
fluorescent
properties
facilitates
uptake
via
cell
endocytosis.
While
this
primarily
focuses
on
recent
advancements
COF‐based
targeted
DDS,
it
acknowledges
challenges
posed
diverse
geometries
materials
discusses
potential
solutions.
Further,
underlines
developing
future
carriers
that
can
successfully
specifically
target
cells,
treatment
efficiency
while
reducing
adverse
side
effects.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(17)
Published: March 8, 2024
Although
being
applied
as
photosensitizers
for
photodynamic
therapy,
covalent
organic
frameworks
(COFs)
fail
the
precise
fluorescence
imaging
in
vivo
and
phototherapy
deep-tissue,
due
to
short
excitation/emission
wavelengths.
Herein,
this
work
proposes
first
example
of
NIR-II
emissive
benzobisthiadiazole-based
COF-980.
Comparing
its
ligands,
structure
COF-980
can
more
efficiently
reducing
energy
gap
(ΔE
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(8), P. 6537 - 6548
Published: April 11, 2024
Herein,
we
have
compared
the
effectivity
of
light-based
photoactivated
cancer
therapy
and
ultrasound-based
sonodynamic
with
Re(I)-tricarbonyl
complexes
(Re1–Re3)
against
cells.
The
observed
photophysical
TD-DFT
calculations
indicated
potential
Re1–Re3
to
act
as
good
anticancer
agents
under
visible
light/ultrasound
exposure.
Re1
did
not
display
any
dark-
or
light-
ultrasound-triggered
activity.
However,
Re2
Re3
displayed
concentration-dependent
activity
upon
light
ultrasound
Interestingly,
produced
1O2
OH•
on
Moreover,
induced
NADH
photo-oxidation
in
PBS
H2O2.
To
best
our
knowledge,
has
been
achieved
here
Re(I)
complex
for
first
time
PBS.
Additionally,
released
CO
cell
death
mechanism
revealed
that
an
apoptotic
response
HeLa
cells
via
ROS
generation.
showed
slightly
better
exposure
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(37)
Published: May 22, 2024
Though
platinum
(Pt)-based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep-seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near-infrared
(NIR)
light-activated
and
lysosomal
targeted
Pt(II)
metallacycle
(1)
supramolecular
ICD
inducer.
1
synergistically
potentiates
immunomodulatory
response
via
multiple-regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth-activated
ROS
production
(~7
mm),
accompanied
by
strong
anti-diffusion
anti-ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer-oxaliplatin
(300
μM).
vivo,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Recent
advances
have
been
made
in
second
near-infrared
(NIR-II)
fluorescence
bioimaging
and
many
related
applications
because
of
its
advantages
deep
penetration,
high
resolution,
minimal
invasiveness,
good
dynamic
visualization.
To
achieve
high-performance
NIR-II
bioimaging,
various
materials
probes
with
bright
emission
extensively
explored
the
past
few
years.
Among
these
emissive
materials,
conjugated
polymers
small
molecules
attracted
wide
interest
due
to
their
native
biosafety
tunable
optical
performance.
This
review
summarizes
brightness
strategies
available
for
highlights
recent
developments
bioimaging.
A
concise,
detailed
overview
molecular
design
regulatory
approaches
is
provided
terms
brightness,
long
wavelengths,
superior
imaging
Then,
typical
cases
which
are
used
as
introduced
by
providing
step-by-step
examples.
Finally,
current
problems
challenges
associated
accessing
briefly
discussed,
significance
future
prospects
proposed
offer
helpful
guidance
development
materials.
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(13), P. 11125 - 11137
Published: June 21, 2024
The
design
of
the
dinuclear
Ru(II)
complex
(Ru2)
with
strong
near-infrared
(NIR)
absorption
properties
has
been
reported
for
efficient
anticancer
phototherapy.
Under
700
nm
LED
light
excitation,
Ru2
exhibited
remarkable
synergistic
type
I/II
photosensitization
ability
and
photocatalytic
activity
toward
intracellular
biomolecules.
showed
impressive
light-triggered
under
normoxia
hypoxia
compared
clinically
used
photosensitizer
Chlorin
e6.
mechanistic
studies
that
induced
redox
imbalance
perturbed
energy
metabolism
biosynthesis
in
A549
cancer
cells.
Overall,
this
work
provides
a
new
strategy
developing
metal-based
complexes
phototherapy
NIR
light.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: June 25, 2024
The
development
of
supramolecular
hosts
which
can
efficiently
encapsulate
photosensitizers
to
improve
the
photodynamic
efficacy
holds
great
promise
for
cancer
therapy.
Here,
we
report
two
perylene
diimide-based
metallacages
that
form
stable
host-guest
complexes
with
planar
conjugated
molecules
including
polycyclic
aromatic
hydrocarbons
and
(hypocrellin
A).
Such
complexation
not
only
prevents
aggregation
in
aqueous
environments,
but
also
offers
fluorescence
resonance
energy
transfer
(FRET)
from
metallacage
further
singlet
oxygen
generation
(Φ
