Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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Blue LED-pumped intense short-wave infrared luminescence based on Cr3+-Yb3+-co-doped phosphors

Light Science & Applications, Journal Year: 2022, Volume and Issue: 11(1)

Published: May 13, 2022

Abstract The growing demand for spectroscopy applications in the areas of agriculture, retail and healthcare has led to extensive research on infrared light sources. ability phosphors absorb blue from commercial LED convert excitation energy into long-wavelength luminescence is crucial design cost-effective high-performance phosphor-converted LEDs. However, lack ideal blue-pumped short-wave (SWIR) with an emission peak longer than 900 nm greatly limits development SWIR LEDs using converter technology. Here we have developed a series SWIR-emitting materials high efficiency excellent thermal stability by co-doping Cr 3+ -Yb ion pairs Lu 0.2 Sc 0.8 BO 3 host materials. Benefitting strong absorption waveband very efficient →Yb transfer, as-synthesized :Cr ,Yb phosphor emits intense 900–1200 Yb under at ~460 nm. optimized presents internal quantum yield 73.6% intensity 100 °C can still keep 88.4% starting value 25 °C. prototype device based exhibits exceptional performance, delivering radiant power 18.4 mW 9.3% blue-to-SWIR conversion 5.0% electricity-to-SWIR 120 mA driving current. Moreover, illumination high-power LED, covert information identification night vision lighting been realized, demonstrating bright prospect practical applications.

Language: Английский

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Xanthene-Based NIR-II Dyes for In Vivo Dynamic Imaging of Blood Circulation

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(41), P. 17136 - 17143

Published: Oct. 11, 2021

Fluorescence bioimaging through the second near-infrared window (NIR-II, 1000–1700 nm) has attracted much attention due to its deep penetration and high contrast. However, exploring new fluorescent materials, especially small molecular fluorophores with long wavelength brightness, is still quite challenging. By expanding π-conjugation enhancing intramolecular charge transfer effect, herein we report a series of xanthene-based NIR-II dyes, named VIXs. Among these VIX-4 exhibits best performance fluorescence emission at 1210 nm brightness been used for dynamically imaging blood flow mice 200 fps. virtue spatiotemporal resolution dynamic imaging, can distinguish directly artery vein direction measure volume by videos. This study provides not only an effective tool spatial temporal but also promising conjugated skeleton dyes.

Language: Английский

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Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(20)

Published: March 3, 2023

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.

Language: Английский

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NIRII‐HDs: A Versatile Platform for Developing Activatable NIR‐II Fluorogenic Probes for Reliable In Vivo Analyte Sensing

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(19)

Published: Feb. 26, 2022

Small-molecule-based second near-infrared (NIR-II) activatable fluorescent probes can potentially provide a high target-to-background ratio and deep tissue penetration. However, most of the reported NIR-II small-molecule exhibit poor versatility owing to lack general stable optically tunable group. In this study, we designed NIRII-HDs, novel dye scaffold optimized for probe development. particular, NIRII-HD5 showed best optical properties such as proper pKa value, excellent stability, brightness, which be beneficial in vivo imaging with contrast. To demonstrate applicability dye, three target-activatable ROS, thiols, enzymes. Using these probes, not only realized reliable different diseases mouse models but also evaluated redox potential liver during injury fidelity.

Language: Английский

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Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 468, P. 214609 - 214609

Published: May 31, 2022

Language: Английский

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Nanochemistry advancing photon conversion in rare-earth nanostructures for theranostics

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 460, P. 214486 - 214486

Published: March 9, 2022

Language: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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Super Broadband Emission Across NIR‐I and NIR‐II Under Blue Light Excitation of Cr³⁺, Ni²⁺ Co‐Doped Sr₂GaTaO₆ Phosphor Achieved by Two‐Site Occupation and Effective Energy Transfer

Laser & Photonics Review, Journal Year: 2024, Volume and Issue: 18(8)

Published: March 20, 2024

Abstract The performance of the near‐infrared phosphor‐converted light‐emitting diodes (NIR pc‐LEDs) mainly depends on NIR emitting phosphors used. Cr 3+ doped materials can be excited by blue light chips, but their emission is located in NIR‐I region (650–1000 nm). Ni 2+ are NIR‐II (1000–1700 nm), they cannot effectively chips. Herein, , mono‐doped, and co‐doped Sr 2 GaTaO 6 prepared investigated. ions occupy two octahedral sites Ga Ta 5+ . co‐doping has achieved breakthroughs. One to shift optimal excitation wavelength from violet due energy transfer (efficiency up 70%) other achieve broadband continuous across regions (650–1700 nm, with a full width at half maximum (FWHM) 410 nm (173 + 237 nm)). : 0.02Cr 0.01Ni phosphor combined commercial 460 chip realize its application organic compounds identification, night vision, biological imaging. This work points out direction for future development efficient super NIR‐emitting phosphors.

Language: Английский

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Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

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