Exosome‐Inhibiting Polymeric Sonosensitizer for Tumor‐Specific Sonodynamic Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 6, 2024

Combination cancer immunotherapy based on electromagnetic energy and shows potent anti-cancer efficacy. However, as a factor that mediates tumor metastasis immune suppression, the impact of exosomes therapy under stimulation remains unclear. Herein, findings indicate sonodynamic (SDT) increases serum exosome levels by inducing apoptotic loosening extracellular matrix, promoting lung metastasis. To address this problem, an exosome-inhibiting polymeric sonosensitizer (EIPS) selectively inhibiting generation in response to biomarker is synthesized. EIPS consists semiconducting polymer backbone capable SDT poly(ethylene glycol) layer conjugated with tumor-specific enzyme-responsive inhibitor prodrug. After being cleaved Cathepsin B, releases active inhibitors, preventing exosome-mediated suppression As result, elicits robust antitumor effects through synergistic effect inhibition, completely establishing long-term memory effect. This first example showing combining inhibition can elicit without help typical agonists.

Language: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

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In situ Thermal-Responsive Magnetic Hydrogel for Multidisciplinary Therapy of Hepatocellular Carcinoma

Nano Letters, Journal Year: 2022, Volume and Issue: 22(6), P. 2251 - 2260

Published: March 7, 2022

Current surgical single modality treatments for hepatocellular carcinoma (HCC) were restricted by recurrence, blood loss, significant trauma, and poor prognostic. Although multidisciplinary strategies HCC treatment have been highly recommended the clinical guidelines, there was limited choice of materials treatments. Herein, we reported an in situ formed magnetic hydrogel with promising bioapplicable thermal-responsiveness, strong adhesion wet conditions, high hyperthermia, biocompatibility, leading to efficient including postoperative transarterial embolization therapy. In vivo results indicated that this could reduce recurrence rate. The hemostatic ability thermal-responsive further demonstrated both liver scratch model tumor resection. Computed tomography imaging suggested completely embolize arterial vessels rabbit vascular intervention operation, which serve as responsive external field body temperature treatment.

Language: Английский

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Manipulating Nanoparticle Aggregates Regulates Receptor–Ligand Binding in Macrophages

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(13), P. 5769 - 5783

Published: March 11, 2022

The receptor–ligand interactions in cells are dynamically regulated by modulation of the ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates ordered at both nanometer and atomic scales. We flexibly anchor tunable sizes over cell-adhesive RGD (Arg-Gly-Asp)-active material surface while maintaining density dispersed ligands accessible to macrophages constant. Lowering dispersity increasing aggregate size constant facilitates binding integrin receptors ligands, which promotes adhesion macrophages. high dispersity, distant manipulation lift (which increases accessibility) stimulates available under augment macrophage adhesion-mediated pro-healing polarization vitro vivo. low control drop decreases repels away from aggregates, thereby suppressing adhesion, inflammatory polarization. Here, present "accessible dispersity" as a novel fundamental parameter that regulates binding, can be reversibly manipulated decreasing Limitless tuning dimensions morphology offer further insight into regulation host cells.

Language: Английский

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Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy

Cancers, Journal Year: 2022, Volume and Issue: 14(13), P. 3084 - 3084

Published: June 23, 2022

Lately, major advances in crucial aspects of magnetic hyperthermia (MH) therapy have been made (nanoparticle synthesis, biosafety, etc.). However, there is one key point still lacking improvement: the field-frequency product (H × f = 4.85 108 Am-1s-1) proposed by Atkinson-Brezovich as a limit for MH therapies. Herein, we analyze both local and systemic physiological effects overpassing this limit.Different combinations field frequency intensity exceeding (591-920 kHz, 10.3-18 kA/m) applied 21 min to WAG/RijHsd male rats, randomly distributed groups 12 animals; half them were sacrificed after h, others 10 days later. Biochemical serum analyses performed assess general, hepatic, renal and/or pancreatic function.MH raised liver temperature 42.8 ± 0.4 °C. Although five exposure was relatively well tolerated, two highest (928 kHz) (18 kA/m), more than 50% animals died. A striking elevation markers observed h surviving animals, independently used. Ten later, almost recovered all animals. those exposed 591 kHz 16 kA/m, 700 13.7 kA/m remained altered.Exceeding up 9.59 109 Am-1s-1 seems be safe, though further research needed understand impact on conditions following MH.

Language: Английский

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The recent progress of inorganic‐based intelligent responsive nanoplatform for tumor theranostics

View, Journal Year: 2022, Volume and Issue: 3(6)

Published: Aug. 22, 2022

Abstract Inorganic nanoplatform exhibits great potentials in drug delivery and responsive release attributed to its inherent physicochemical properties, good biocompatibility, surface modification, easy synthesis. In this review, the recent progresses on inorganic smart bio‐responsive nanoplatforms for tumor theranostics are summarized, which could be triggered by either endogenous microenvironment (TME) or exogenous physical hopeful achieve safe, precise, high efficacy therapy. Notably, these generally dependent intelligent multifunctional design of nanocarriers, including mesoporous silica nanoparticles (MSNs), black phosphorus (BP), Prussian blue (PB), other inorganic‐based nanoparticles. Finally, perspectives challenges future translational medicine proposed.

Language: Английский

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Lymph node-targeting nanovaccines for cancer immunotherapy

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 102 - 122

Published: Sept. 20, 2022

Language: Английский

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Mild photothermal therapy boosts nanomedicine antitumor efficacy by disrupting DNA damage repair pathways and modulating tumor mechanics

Nano Today, Journal Year: 2023, Volume and Issue: 49, P. 101767 - 101767

Published: Jan. 28, 2023

Language: Английский

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Dual Tumor Exosome Biomarker Co-recognitions Based Nanoliquid Biopsy for the Accurate Early Diagnosis of Pancreatic Cancer

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11384 - 11395

Published: June 8, 2023

Pancreatic cancer, with extremely limited treatment options and poor prognosis, urgently needs a breakthrough in early diagnosis monitoring. Tumor exosomes (T-Exos) detection is presently one of the most clinically significant liquid biopsy approaches for non-invasive pancreatic cancer diagnosis, which, unfortunately, cannot be applied as routine diagnostic tool until number obstacles, such unsatisfactory specificity sensitivity, well labor-intensive purification analysis procedures by ultracentrifugation enzyme-linked immunosorbent assay, are overcome. Here, we report facile nanoliquid assay especially specific, ultrasensitive yet economical T-Exos dual specific biomarker antigen co-recognition capturing strategy, which enabled grafting two corresponding capture antibodies on magnetic nanoparticles gold nanoparticles, accurate target tumor exosomes. This approach exhibits excellent ultrahigh sensitivity detecting low 78 pg/mL exosome protein GPC1. Successful screening 21 samples from 22 normal control cases enhanced ensures promising monitoring stage cancer.

Language: Английский

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Liquid metal microspheres with an eddy-thermal effect for magnetic hyperthermia-enhanced cancer embolization-immunotherapy

Science Bulletin, Journal Year: 2023, Volume and Issue: 68(16), P. 1772 - 1783

Published: July 19, 2023

Language: Английский

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