Recent trends of mesoporous silica-based nanoplatforms for nanodynamic therapies

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 469, P. 214687 - 214687

Published: June 27, 2022

Language: Английский

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)

Published: July 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Language: Английский

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Nanochemistry advancing photon conversion in rare-earth nanostructures for theranostics

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 460, P. 214486 - 214486

Published: March 9, 2022

Language: Английский

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Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332

Published: July 17, 2023

Language: Английский

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Small molecular cyanine dyes for phototheranostics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215986 - 215986

Published: June 2, 2024

Language: Английский

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Lanthanide porphyrinoids as molecular theranostics

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6177 - 6209

Published: Jan. 1, 2022

This Review summarises the history and ‘state-of-the-art’ development of lanthanide (Ln) porphyrinoids as theranostic agents. Applications such near-infrared (NIR) fluorescence imaging (FL), magnetic resonance (MRI), radiotherapy, chemotherapy phototheranostics will be discussed.

Language: Английский

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Functionalization of luminescent lanthanide complexes for biomedical applications

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 474, P. 214866 - 214866

Published: Oct. 8, 2022

Language: Английский

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Nonaromatic Organonickel(II) Phototheranostics

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(16), P. 7346 - 7356

Published: April 14, 2022

Earth-abundant metal-based theranostics, agents that integrate diagnostic and therapeutic functions within the same molecule, may hold key to development of low-cost personalized medicines. Here, we report a set O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic organonickel(II) complexes, Ni-1–4, containing strong σ-donating M–C bonds. Complexes Ni-1–4 are characterized by square-planar coordination geometry as inferred from structural studies Ni-1. They photothermal therapy, imaging, photoacoustic imaging (PAI) one system. This makes them attractive potential phototheranostics. Relative traditional Ni(II) porphyrins, such F20TPP (tetrapentafluorophenylporphyrin), lowest energy absorption Ni-1 is shifted into near infrared region, presumably consequence Ni–C bonding. Ultrafast transient spectroscopy combined with theoretical calculations revealed that, upon photoexcitation, higher population ligand-centered 3MLCT states seen in relative NiTPBP (TPBP = 6,11,16,21-tetraphenylbenziporphyrin). Encapsulating 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000) afforded nanoparticles, Ni-1@DSPE, displaying red-shifted features, well good conversion efficiency (∼45%) aqueous media. Proof-of-principle experiments involving thrombus treatment were carried out both vitro vivo. It was found Ni-1@DSPE combination 785 nm photo-irradiation for 3 min (0.3 W/cm2) proved successful removing blood clots mouse model monitored (PAI). The present work highlights promise complexes theranostics benefits can accrue manipulating excited-state features early transition-metal via, example, interrupting π-conjugation pathways.

Language: Английский

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Copper-Nitrogen-Coordinated Carbon Dots: Transformable Phototheranostics from Precise PTT/PDT to Post-Treatment Imaging-Guided PDT for Residual Tumor Cells

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(2), P. 3253 - 3265

Published: Jan. 4, 2023

Phototheranostics has attracted considerable attention in the fields of cancer diagnosis and treatment. However, complete eradication solid tumors using traditional phototheranostics is difficult because limited depth range laser irradiation. New enabling precise phototherapy post-treatment imaging-guided programmed therapy for residual urgently required. Accordingly, this study developed a novel transformable by assembling hyaluronic acid (HA) with copper-nitrogen-coordinated carbon dots (CDs). In nanoplatform, named copper-nitrogen-CDs@HA, HA component enables specific targeting cluster determinant (CD) 44-overexpressing tumor cells. cells, redox glutathione converts Cu(II) (cupric ions) into Cu(I) (cuprous ions), which confers functionality to phototheranostics. Both vitro vivo results reveal that near-infrared-light-photoactivated CuII-N-CDs@HA could target CD44-overexpressing cells synergistic photothermal photodynamic therapy. This first observe escape from lysosomes be transformed situ CuI-N-CDs@HA d9 electronic configuration changing d10 Cu(I), turns on their fluorescence off properties. used Thus, rationally designed CDs offer simple transformation strategy multiple-stimulus-responsive monitoring

Language: Английский

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NIR‐II Perylene Monoimide‐Based Photothermal Agent with Strengthened Donor–Acceptor Conjugation for Deep Orthotopic Glioblastoma Phototheranostics

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 12, 2023

Abstract Extensive efforts have been devoted to the design of organic photothermal agents (PTAs) that absorb in second near‐infrared (NIR‐II) bio‐window, which can provide deeper tissue penetration is significant for phototheranostics lethal brain tumors. Herein, first example NIR‐II‐absorbing small molecule (N1) derived from perylene monoamide (PMI) and its bio‐application after nano‐encapsulation N1 function as a nano‐agent deep orthotopic glioblastoma (GBM) reported. By adopting dual modification strategy introducing donor‐acceptor unit extending π‐conjugation, obtained 1000–1400 nm region exhibit high conversation due apparent intramolecular charge transfer (ICT). A choline analogue, 2‐methacryloyloxyethyl phosphorylcholine, capable interacting specifically with receptors on surface blood‐brain barrier (BBB), used fabricate amphiphilic copolymer N1. The nanoparticles demonstrate efficient BBB‐crossing receptor‐mediated transcytosis well nanoparticle size approximately 26 nm. prepared excellent photoacoustic imaging growth inhibition GBM. current study demonstrates enormous potential PMI‐based NIR‐II PTAs provides an phototheranostic paradigm

Language: Английский

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