NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(38)

Published: July 18, 2022

Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano‐sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining application SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich vacancies developed interlayer gaps trioxide nanobelts expanded. Owing to increased vacancy density wide gap‐induced narrower band gap SMB NPs, electrons (e – ) holes (h + generated by US separated more rapidly, prevent electrons–holes recombination under irradiation. NPs exhibit second near‐infrared (NIR‐II) photothermal effect promote generation ROS sonosensitizer. The system is successfully realized eliminate Staphylococcus aureus ( S. dissipate biofilm. Therefore, multimodal using serves as an effective promising regimen for deep‐seated bacterial infections. newly Mo‐based sonosensitizer presented first time demonstrate excellent antimicrobial activity through hyperthermia‐promoting SDT therapeutics. This work proposes novel strategy field NIR‐II photo‐amplified materials eradication other important biomedical applications.

Language: Английский

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Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 289 - 299

Published: Feb. 1, 2022

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various strategies based on ROS have been developed, many them still limited by insufficient efficiency. Here, we developed acid-enhanced dual-modal strategy zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn

Language: Английский

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Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(19), P. 5369 - 5390

Published: Jan. 1, 2022

Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials.

Language: Английский

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Sulfur-regulated defect engineering for enhanced ultrasonic piezocatalytic therapy of bacteria-infected bone defects

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134624 - 134624

Published: Jan. 11, 2022

Language: Английский

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Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment

Science Advances, Journal Year: 2023, Volume and Issue: 9(10)

Published: March 8, 2023

Acne is an inflammatory skin disease mainly caused by Propionibacterium acnes, which can cause local reactions and develop into chronic diseases in severe cases. To avoid the use of antibiotics to effectively treat site acne, we report a sodium hyaluronate microneedle patch that mediates transdermal delivery ultrasound-responsive nanoparticles for effective treatment acne. The contains formed zinc porphyrin-based metal-organic framework oxide (ZnTCPP@ZnO). We demonstrated activated oxygen-mediated killing P. acnes with antibacterial efficiency 99.73% under 15 min ultrasound irradiation, resulting decrease levels acne-related factors, including tumor necrosis factor-α, interleukins, matrix metalloproteinases. ions up-regulated DNA replication-related genes, promoting proliferation fibroblasts and, consequently, repair. This research leads highly strategy acne through interface engineering response.

Language: Английский

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Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 8, 2023

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.

Language: Английский

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Piezo-Augmented Sonosensitizer with Strong Ultrasound-Propelling Ability for Efficient Treatment of Osteomyelitis

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 2546 - 2557

Published: Jan. 19, 2022

The successful treatment of osteomyelitis remains a great challenge in the field orthopedics. clinical method for treating refractory bone infection requires combination therapy long-term systemic antibiotics administration and surgical debridement. It is highly desirable to develop an antibiotic-free, noninvasive, rapid strategy eradicate osteomyelitis. Herein, we fabricate piezoelectric-enhanced sonosensitizer that consists porphyrin-based hollow metal–organic framework (HNTM), MoS2 nanosheets, red cell (RBC) membrane. We find ultrasound (US)-induced piezoelectric polarization can improve charge transfer HNTM at heterointerface HNTM-MoS2, increasing production reactive oxygen species (ROS). Besides, increases asymmetric shape HNTM, leading strong US-propelling ability HNTM–MoS2. produced ROS mechanical force kill methicillin-resistant Staphylococcus aureus (MRSA) with antibacterial efficiency 98.5% under 15 min US treatment, resulting intracellular DNA damage increased oxidative stress disturbance purine metabolism, tryptophan pantothenate CoA biosynthesis MRSA. Together toxin neutralization ability, RBC-HNTM-MoS2 successfully eliminates suppresses inflammation loss. This work provides another developing efficient through piezoelectric-assisted sonocatalysis enhancing ability.

Language: Английский

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Boronic Acid-Decorated Multivariate Photosensitive Metal–Organic Frameworks for Combating Multi-Drug-Resistant Bacteria

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7732 - 7744

Published: May 10, 2022

Metal–organic frameworks (MOFs) are promising photosensitized materials that have displayed great advantages in antibacterial application. However, their bactericidal activity is still limited by the ultrashort diffusion distance of biocidal reactive oxygen species (ROS). Herein, we integrate bacterial-binding boronic acid ligand and porphyrin into one single MOF, synergistically boosting antibiotic capability. The introduction group with a closed physical gap makes multivariate MOFs more powerful for eradicating multi-drug-resistant (MDR) bacteria. decorated possess efficiencies (10–20 times) higher than those without targeting ligand. Moreover, exhibit excellent biocompatibility. They significantly decrease inflammatory responses accelerate healing chronic wounds infected MDR bacteria (nearly 2 times faster). This work provides strategy to develop target bacteria, which will further inspire specific therapy future.

Language: Английский

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Engineering single-atom catalysts toward biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3688 - 3734

Published: Jan. 1, 2022

Due to inherent structural defects, common nanocatalysts always display limited catalytic activity and selectivity, making it practically difficult for them replace natural enzymes in a broad scope of biologically important applications. By decreasing the size nanocatalysts, their selectivity will be substantially improved. Guided by this concept, advances now enter an era atomic-level precise control. Single-atom catalysts (denoted as SACs), characterized atomically dispersed active sites, strikingly show utmost atomic utilization, precisely located metal centers, unique metal-support interactions identical coordination environments. Such advantages SACs drastically boost specific per atom, thus provide great potential achieving superior functionally mimic or even outperform interest. Although does matter, is not clear whether guideline "the smaller, better" still correct developing at single-atom scale. Thus, clearly new, urgent issue address before further extending into biomedical applications, representing branch nanomedicine. This review begins providing overview recent synthesis strategies SACs, which serve basis discussion emerging achievements improving enzyme-like properties level. Then, we carefully compare structures functions various scales from nanoparticles, nanoclusters, few-atom clusters single atoms. Contrary conventional wisdom, are most catalytically reactions, especially those requiring multi-site auxiliary activities. After that, highlight roles toward To appreciate these advances, challenges prospects rapidly growing studies SACs-related nanomedicine also discussed review.

Language: Английский

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Electrochemiluminescence metal-organic frameworks biosensing materials for detecting cancer biomarkers

TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 157, P. 116735 - 116735

Published: July 12, 2022

Language: Английский

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