Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(6), P. 1994 - 2019
Published: Jan. 1, 2023
This work demonstrates different stimulus-based antibacterial treatment strategies for both resistant bacteria and biofilms. Moreover, a future perspective has been illustrated making these modalities clinically feasible.
Language: Английский
Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100508 - 100508
Published: Nov. 30, 2022
Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection impaired tissue remodeling are the main features diabetic healing. Conventional dressings, including gauze, films bandages, limited function. They generally act as physical barriers absorbers exudates, which fail to meet requirements whol process. Wounds in patients typically heal slowly due hyperglycemia within bed. Once bacterial cells develop into biofilms, wounds will exhibit robust drug resistance. Recently, application stimuli-responsive hydrogels, also known "smart hydrogels", for has attracted particular attention. The basic feature this system is capacities change mechanical properties, swelling ability, hydrophilicity, permeability biologically active molecules, etc., response various stimuli, temperature, potential hydrogen (pH), protease other biological factors. Smart hydrogels can improve therapeutic efficacy limit total toxicity according characteristics wounds. In review, we summarized mechanism It hoped that work provide some inspiration suggestions research field.
Language: Английский
Citations
137
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Nov. 1, 2023
The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy use tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome stromal barrier for management triple-negative breast cancer (TNBC). SnSNPs possess narrow bandgap (1.18 eV), allowing efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, display mild photothermal properties in situ denature collagen facilitate deep into mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by boosts immunity. In mouse models malignant TNBC hepatocellular carcinoma (HCC), combination robust SDT enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. study presents an innovative enhance immunity using strategy, offering potential combined sono-immunotherapy nanomedicine field.
Language: Английский
Citations
111
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)
Published: Feb. 13, 2023
Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.
Language: Английский
Citations
89
ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(47), P. 52643 - 52658
Published: Nov. 16, 2022
The high level of reactive oxygen species (ROS) and bacterial infection impede wound healing the diabetic wound. Here, benefiting from antioxidation effects tannic acid (TA) ROS-responsive phenylborate ester (PBAE), a series anti-inflammatory TA-conjugated nanoparticle hydrogels (PPBA-TA-PVA) can be obtained by conveniently mixing TA, phenylboric modified polyphosphazene (PPBA), poly(vinyl alcohol) (PVA). PPBA-TA-PVA could effectively inhibit growth Escherichia coli (antibacterial rate = 93.1 ± 1.1%) within 4 h scavenge both 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals •OH in vitro. Besides, cell migration HDFa cells treated with (84.2 4.6%) was twice normal (43.8 8.1%) after 24 cocultivation. clinical relevance demonstrated further assessing full-thickness excisional wounds streptozotocin (STZ)-induced rat model. act as effective ROS-scavenging agents to alleviate inflammation accelerate closure decreasing proinflammatory cytokines (IL-6, IL-1β) increasing gene expression TGF-β1, COL-1, COL-3, which resulted faster re-epithelialization increased formation granulation tissue.
Language: Английский
Citations
74
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547
Published: May 24, 2024
Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing
Language: Английский
Citations
73
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(26)
Published: March 21, 2023
Bacterial infections, such as bacterial keratitis (BK) and subcutaneous abscess, pose significant challenges to global healthcare. Innovative new antibacterial agents strategies are in demand control infections this era of high drug resistance. Nanotechnology is gradually emerging an economically feasible effective anti-infection treatment. High-entropy MXenes (HE MXenes) used confer desirable properties with exposed active sites high-entropy atomic layers, whose potential application the field biomedicine remains be explored. Herein, monolayer HE fabricated by implementing transition metals entropy low Gibbs free energy fill gap biocatalytic performance non-high-entropy MXenes. endowed extremely strong oxidase mimic activity (Km = 0.227 mm) photothermal conversion efficiency (65.8%) second near-infrared (NIR-II) biowindow increases. Subsequently, realize NIR-II-enhanced intrinsic for killing methicillin-resistant Staphylococcus aureus rapidly removing biofilm. Furthermore, can effectively treat BK abscess infection induced nanotherapeutic minuscule side effects. Overall, demonstrate promising clinical treatment drug-resistant promote healing infected tissues.
Language: Английский
Citations
72
Materials Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 7(8), P. 1684 - 1693
Published: Jan. 1, 2023
2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.
Language: Английский
Citations
71
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)
Published: March 12, 2024
Abstract Given the challenge of multidrug resistance in antibiotics, non‐antibiotic–dependent antibacterial strategies show promise for anti‐infective therapy. V 2 C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) therapy (PTT). However, limitation MXene's laser irradiation to near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult achieve complete bacterial eradication with single‐effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached C, forming artificial nanoplatforms (Pt@V C). Pt@V exhibits enhanced PCE (59.6%) a longer (NIR‐II) due surface plasmon resonance effect NPs C. Notably, displays dual enzyme‐like activity chemodynamic (CDT) NIR‐II activity. The biocatalytic mechanism is elucidated using density functional theory. In an vivo animal model, effectively eliminates methicillin‐resistant Staphylococcus aureus from deep‐seated tissues subcutaneous abscesses keratitis environments, accelerating abscess resolution promoting wound cornea healing through synergistic effects PTT/CDT. Transcriptomic analysis reveals that targets inflammatory pathways, providing insight into its mechanism. This study presents promising approach involving hyperthermia‐amplified biocatalysis MXene nanocomposites.
Language: Английский
Citations
70
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: April 21, 2024
Abstract Persistent oxidative stress and bacterial infection are significant challenges that impede diabetic wound healing. By combining diagnosis treatment, pH variation on the tissue can be monitored in real time, precise treatment carried out promptly to promote In this study, a lipoic acid‐modified chitosa (LAMC) hydrogel is constructed via an amidation reaction, ceria oxide‐molybdenum disulfide nanoparticles with polydopamine layer (C@M@P), along carbon quantum dots (CDs) synthesized by hydrothermal method, loaded into hydrogel, thus developing diagnostic therapeutic (LAMC/CD‐C@M@P). incorporating CDs, exhibits high sensitivity reversibility under ultraviolet light. Furthermore, images of hydrogels collected using smartphones converted signals, providing means for early detection infection. Notably, LAMC/CD‐C@M@P excellent photothermal antibacterial capability against Staphylococcus aureus Escherichia coli remarkable antioxidant anti‐inflammatory abilities alleviate reactive oxygen species relieve inflammation response. summary, multifunctional offers great potential as innovative dressing platform, representing advancement chronic management.
Language: Английский
Citations
62
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 492, P. 215275 - 215275
Published: June 7, 2023
Language: Английский
Citations
59