Supramolecular Enhancement of Charge Transport through Pillar[5]arene‐Based Self‐Assembled Monolayers DOI
Xiaobing Li, Siyuan Zhou, Qi Zhao

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(19)

Published: Feb. 2, 2023

Intermolecular charge transport is one of the essential modes for modulating in molecular electronic devices. Supermolecules are highly promising candidates devices because their abundant structures and easy functionalization. Herein, we report an efficient strategy to enhance through pillar[5]arene self-assembled monolayers (SAMs) by introducing cationic guests. The current density SAMs can be raised up about 2.1 orders magnitude inserting molecules into cavity pillar[5]arenes SAMs. Importantly, have also observed a positive correlation between pillar[5]arene-based complex binding affinities complexation. Such enhancement attributed host-guest interactions that stabilize supramolecular complexes lower energy gaps transport. This work provides predictive pattern regulation intermolecular guiding design next generation switches functional sensors electronics.

Language: Английский

Fast-Specific Fluorescent Probes to Visualize Norepinephrine Signaling Pathways and Its Flux in the Epileptic Mice Brain DOI

Huming Yan,

Yuting Wang, Fangjun Huo

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(5), P. 3229 - 3237

Published: Jan. 26, 2023

Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout brain spinal cord. It regulates various actions consciousness linked to a variety of neurological diseases. A "hunting-shooting" strategy was proposed this work improve specificity response rate an NE fluorescent probe: 2-(cyclohex-2-en-1-ylidene)malononitrile derivatives were chosen as fluorophore. To create dual-site probe, aldehyde group added ortho ester (or benzene sulfonate). Because its excellent electrophilic activity, could rapidly "hunt" amino then form intramolecular five-membered ring via nucleophilic reaction with β-hydroxyl group. The -NH- "shoots" adjacent group, releasing fluorophore allowing for rapid specific detection. release reuptake ″emetic″-″swallow″ transient process captured visualized under action primary receptor drug. Furthermore, by introducing halogen into lengthen absorption wavelength, lipid solubility, adjust pKa appropriately, probe successfully penetrated blood-brain barrier (BBB). In situ synchronous imaging used detect level brains epileptic normal mice, abnormal expression discovered during epilepsy. Brain anatomy examine distribution changes regions before after This research provides useful tools theoretical foundation diagnosing treating central nervous system diseases early.

Language: Английский

Citations

82
Fluorescent proteins and genetically encoded biosensors DOI
Minji Wang,

Yifan Da,

Yang Tian

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(4), P. 1189 - 1214

Published: Jan. 1, 2023

The genetically encoded fluorescent sensors convert chemical and physical signals into light. They are powerful tools for the visualisation of physiological processes in living cells freely moving animals. protein is reporter module a biosensor. In this study, we first review history full emission spectra on structural basis. Then, discuss design Finally, briefly several major types biosensors that currently widely used based their molecular targets, which may be useful future biosensors.

Language: Английский

Citations

75
Machine learning-assisted optical nano-sensor arrays in microorganism analysis DOI
Jianyu Yang, Shasha Lu, Bo Chen

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 159, P. 116945 - 116945

Published: Jan. 20, 2023

Language: Английский

Citations

46
Supramolecular systems for bioapplications: recent research progress in China DOI
Yue‐Yang Liu, Xiao-Yong Yu, Yu‐Chen Pan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

Citations

28
Electrochemical Self-Sacrificial Label Conversion Coupled with DNA Framework Nanomachine Mediated Serotonin Sensing with Highly Minimized Background Noise DOI
Baoting Dou, Yan Chen, Qiumei Feng

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Conventional solid/liquid electrochemical interfaces typically encounter challenges with impeded mass transport for poor quantification due to the intricate pathways of reactants from bulk solution. To address this issue, work reports an innovative approach integrating a target-activated DNA framework nanomachine electrochemically driven metal-organic (MOF) conversion self-sacrificial biosensing. The presence target biomarker serotonin initiates by entropy-driven circuit form cross-linked nanostructure and subsequently release Fe-MOF probe. Acting as natural metal precursor nanoconfined source reactant, probe is converted into electroactive Prussian Blue during processes. Taking advantage confinement effect, our proposed biosensor exhibits excellent capability detect in linear range 1 pM 5 μM remarkable detection limit 0.4 exceptional specificity against other interferents. proof-of-concept demonstration clinical serum samples patients carcinoid tumors highlights utility complex sample analysis. design could be applied high potential inspire sensing approaches, holding promise applications biomedical research disease diagnosis.

Language: Английский

Citations

3
Real-Time Monitoring of Neurotransmitters in the Brain of Living Animals DOI

Yifan Da,

Shihua Luo,

Yang Tian

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 15(1), P. 138 - 157

Published: April 8, 2022

Neurotransmitters, as important chemical small molecules, perform the function of neural signal transmission from cell to cell. Excess concentrations neurotransmitters are often closely associated with brain diseases, such Alzheimer's disease, depression, schizophrenia, and Parkinson's disease. On other hand, release under induced stimulation indicates occurrence reward-related behaviors, including food drug addiction. Therefore, understand physiological pathological functions neurotransmitters, especially in complex environments living brain, it is urgent develop effective tools monitor their dynamics high sensitivity specificity. Over past 30 years, significant advances electrochemical sensors optical probes have brought new possibilities for studying neurons circuits by monitoring changes neurotransmitters. This Review focuses on progress construction vivo analysis summarizes current attempts address key issues development selectivity, sensitivity, stability. Combined latest technologies methods, several strategies sensor provided recording environment brain.

Language: Английский

Citations

56
Further Dimensions for Sensing in Biofluids: Distinguishing Bioorganic Analytes by the Salt-Induced Adaptation of a Cucurbit[7]uril-Based Chemosensor DOI Creative Commons
Chang‐Ming Hu, Thomas Jochmann, Papri Chakraborty

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(29), P. 13084 - 13095

Published: July 18, 2022

Insufficient binding selectivity of chemosensors often renders biorelevant metabolites indistinguishable by the widely used indicator displacement assay. Array-based chemosensing methods are a common workaround but require additional effort for synthesizing chemosensor library and setting up sensing array. Moreover, it can be very challenging to tune inherent preference macrocyclic systems such as cucurbit[n]urils (CBn) synthetic means. Using novel cucurbit[7]uril-dye conjugate that undergoes salt-induced adaptation, we now succeeded in distinguishing 14 bioorganic analytes from each other through facile stepwise addition salts. The salt-specific concentration-resolved emission provides information about system at low effort. We present data-driven approach translate human-visible curve differences into intuitive pairwise difference measures. Ion mobility experiments combined with density functional theory calculations gave further insights mechanism uncovered an unprecedented ternary complex geometry CB7. TThis work introduces non-selectively binding, salt-adaptive cucurbit[n]uril applications biofluids urine, saliva, blood serum.

Language: Английский

Citations

53
Two Ratiometric Fluorescent Probes Based on the Hydroxyl Coumarin Chalcone Unit with Large Fluorescent Peak Shift for the Detection of Hydrazine in Living Cells DOI

Miaomiao Xing,

Yanyan Han,

Yilin Zhu

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(37), P. 12836 - 12844

Published: Sept. 5, 2022

Hydrazine is widely used in industrial and agricultural production, but excessive hydrazine possesses a serious threat to human health environment. Here two new ratiometric fluorescence probes, DDP DDC, with the hydroxyl coumarin chalcone unit as sensing site are developed, which can achieve colorimetric recognition for good sensitivity, excellent selectivity, anti-interference. The calculated limits of detections 0.26 μM (DDC) 0.14 (DDP). response realized through adjustment donor receptor units conjugate structure terminals, accompanied by peak shift about 200 nm (DDC, 188 nm; DDP, 229 nm). Stronger electropositivity carbon-carbon double bond helpful first phase addition reaction between probe hydrazine. Higher phenol activity moiety will facilitate following dihydro-pyrazole cyclization reaction. In addition, both these probes convenient detection vapor. were also successfully applied detect actual water samples, different soils, living cells.

Language: Английский

Citations

50
Recent Advances in Colorimetric Sensors Based on Gold Nanoparticles for Pathogen Detection DOI Creative Commons
Jianyu Yang, Xin Wang, Yuyang Sun

et al.

Biosensors, Journal Year: 2022, Volume and Issue: 13(1), P. 29 - 29

Published: Dec. 26, 2022

Infectious pathogens cause severe threats to public health due their frightening infectivity and lethal capacity. Rapid accurate detection of is great significance for preventing infection. Gold nanoparticles have drawn considerable attention in colorimetric biosensing during the past decades unique physicochemical properties. Colorimetric diagnosis platforms based on functionalized AuNPs are emerging as a promising pathogen-analysis technique with merits high sensitivity, low-cost, easy operation. This review summarizes recent development this field. We first introduce detecting characteristics gold nanoparticles. Four types strategies, including application indirect target-mediated aggregation, chromogenic substrate-mediated catalytic activity, point-of-care testing (POCT) devices, machine learning-assisted sensor arrays, systematically introduced. In particular, three biomolecule-functionalized AuNP-based sensors described detail. Finally, we conclude by presenting our subjective views present challenges some appropriate suggestions future research directions sensors.

Language: Английский

Citations

49
Two-photon fluorescence imaging and specifically biosensing of norepinephrine on a 100-ms timescale DOI Creative Commons

Leiwen Mao,

Yujie Han, Qi‐Wei Zhang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 14, 2023

Abstract Norepinephrine (NE) is a key neurotransmitter in the central nervous system of organisms; however, specifically tracking transient NE dynamics with high spatiotemporal resolution living systems remains great challenge. Herein, we develop small molecular fluorescent probe that can precisely anchor on neuronal cytomembranes and respond to 100-ms timescale. A unique dual acceleration mechanism molecular-folding water-bridging disclosed, which boosts reaction kinetics by ˃10 5 3 times, respectively. Benefiting from its excellent resolution, applied monitor at single-neuron level, thereby, successfully snapshotting fast fluctuation levels within 2 s. Moreover, two-photon fluorescence imaging acute brain tissue slices reveals close correlation between downregulated Alzheimer’s disease pathology as well antioxidant therapy.

Language: Английский

Citations

39