A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions

Chemical Science, Journal Year: 2023, Volume and Issue: 14(26), P. 7170 - 7184

Published: Jan. 1, 2023

Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive species (ROS) hampers its therapeutic efficacy, especially against hypoxic solid tumors. In addition, some photosensitizers (PSs) have dark toxicity and are only activatable with short wavelengths such as blue or UV-light, which suffer from poor tissue penetration. Herein, we developed novel hypoxia-active PS operability in near-infrared (NIR) region based on conjugation cyclometalated Ru(ii) polypyridyl complex type [Ru(C^N)(N^N)2] NIR-emitting COUPY dye. The Ru(ii)-coumarin conjugate exhibits water-solubility, stability biological media high photostability along advantageous luminescent properties that facilitate both bioimaging phototherapy. Spectroscopic photobiological studies revealed this efficiently generates singlet superoxide radical anions, thereby achieving photoactivity toward cells upon highly-penetrating 740 nm light irradiation even under environments (2% O2). induction ROS-mediated cell death low-energy wavelength low exerted by could circumvent penetration issues while alleviating hypoxia limitation PDT. As such, strategy pave way development NIR- Ru(ii)-based theragnostic PSs fuelled tunable, molecular-weight fluorophores.

Language: Английский

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Recent progress in metal complexes functionalized nanomaterials for photodynamic therapy

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(46), P. 6956 - 6968

Published: Jan. 1, 2023

The recent developments and applications of metal complexes functionalized nanomaterials for photodynamic cancer therapy are reviewed.

Language: Английский

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An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death

Chemical Science, Journal Year: 2024, Volume and Issue: 15(18), P. 6752 - 6762

Published: Jan. 1, 2024

A mitochondria-localizing iridium( iii ) photosensitizer produces singlet oxygen and superoxide anion radicals upon two-photon irradiation, disrupting the mitochondrial respiratory chain inducing ferritinophagy immunogenic cell death.

Language: Английский

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A Semi‐Automated, High‐Throughput Approach for the Synthesis and Identification of Highly Photo‐Cytotoxic Iridium Complexes

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(18)

Published: Feb. 26, 2024

The discovery of new compounds with pharmacological properties is usually a lengthy, laborious and expensive process. Thus, there increasing interest in developing workflows that allow for the rapid synthesis evaluation libraries aim identifying leads further drug development. Herein, we apply combinatorial to build library 90 iridium(III) complexes (81 which are new) over two synthesise-and-test cycles, potential agents photodynamic therapy. We demonstrate power this approach by highly active well-tolerated dark but display very low nM phototoxicity against cancer cells. To detailed structure-activity relationship class have used density functional theory (DFT) calculations determine some key electronic parameters study correlations experimental data. Finally, present an optimised semi-automated protocol obtain multiplex data within 72 hours.

Language: Английский

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Systematic review on antibacterial photodynamic therapeutic effects of transition metals ruthenium and iridium complexes

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 255, P. 112523 - 112523

Published: March 11, 2024

Language: Английский

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